Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	E	F	S	I	L	C	R	V	L	G	S	L	Y	Y	R	Q	P	Q	D	P	L	L	V	P	L	F	T	L	I	R	E	G	K	L	A	A	N	W	P	L	E	Q	D	E	L	L	T	R	L	Q	K	S	C	D	M	T	Q	V
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	A	D	Y	N	A	L	F	I	G	D	E	C	A	V	P	P	Y	R	S	A	W	V	E	G	A	T	E	A	E	V	R	A	F	L	S	E	R	G	M	P	L	A	D	T	P	A	D	H	I	G	T	L	L	L	A	A	S	W	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	D	Q	S	T	E	D	E	S	E	A	L	E	T	L	F	S	E	Y	L	L	P	W	C	G	A	F	L	G	K	V	E	A	H	A	T	T	P	F	W	R	T	M	A	P	L	T	R	D	A	I	S	A	M	W	D	E	L	E	E
Secondary structure
SS confidence
Disorder							?		?																																																			?	?
Disorder confidence
		.	.	.	.
Sequence		D	S	E	E
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1s9u chain A Region: 2 - 184 Aligned: 177 Modelled: 183 Confidence: 100.0% Identity: 32% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 1n1c chain A Region: 1 - 183 Aligned: 179 Modelled: 183 Confidence: 100.0% Identity: 19% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2o9x chain A Region: 5 - 172 Aligned: 143 Modelled: 154 Confidence: 100.0% Identity: 24% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus Phyre2 PDB 2o9x chain A domain 1 Region: 7 - 172 Aligned: 141 Modelled: 153 Confidence: 100.0% Identity: 23% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2idg chain A domain 1 Region: 4 - 167 Aligned: 140 Modelled: 158 Confidence: 99.8% Identity: 19% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 3bf2 chain A Region: 77 - 108 Aligned: 31 Modelled: 32 Confidence: 22.3% Identity: 26% PDB header:lipoprotein Chain: A: PDB Molecule:putative lipoprotein; PDBTitle: crystal structure of the a1ksw9_neimf protein from2 neisseria meningitidis. northeast structural genomics3 consortium target mr36a Phyre2 PDB 2zop chain A Region: 108 - 153 Aligned: 44 Modelled: 46 Confidence: 14.4% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein tthb164; PDBTitle: x-ray crystal structure of a crispr-associated cmr5 family2 protein from thermus thermophilus hb8 Phyre2 PDB 1ysg chain A domain 1 Region: 109 - 146 Aligned: 38 Modelled: 38 Confidence: 13.3% Identity: 21% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1q8h chain A Region: 105 - 113 Aligned: 9 Modelled: 9 Confidence: 9.6% Identity: 56% Fold: GLA-domain Superfamily: GLA-domain Family: GLA-domain Phyre2 PDB 1q8h chain A Region: 105 - 113 Aligned: 9 Modelled: 9 Confidence: 9.6% Identity: 56% PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin Phyre2 PDB 3qbr chain A Region: 109 - 144 Aligned: 36 Modelled: 36 Confidence: 9.1% Identity: 14% PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja Phyre2 PDB 1f16 chain A Region: 109 - 146 Aligned: 38 Modelled: 38 Confidence: 8.5% Identity: 24% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2pon chain B domain 1 Region: 109 - 146 Aligned: 38 Modelled: 38 Confidence: 8.5% Identity: 21% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1g5m chain A Region: 110 - 146 Aligned: 37 Modelled: 37 Confidence: 7.5% Identity: 14% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1pq1 chain A Region: 109 - 146 Aligned: 38 Modelled: 38 Confidence: 7.3% Identity: 21% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2vof chain A Region: 109 - 146 Aligned: 38 Modelled: 38 Confidence: 7.1% Identity: 13% PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain Phyre2 PDB 1q3m chain A Region: 105 - 113 Aligned: 9 Modelled: 9 Confidence: 6.9% Identity: 56% Fold: GLA-domain Superfamily: GLA-domain Family: GLA-domain Phyre2 PDB 1rut chain X domain 2 Region: 61 - 68 Aligned: 8 Modelled: 8 Confidence: 6.4% Identity: 50% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 1m3v chain A domain 2 Region: 61 - 68 Aligned: 8 Modelled: 8 Confidence: 6.2% Identity: 50% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 1zy3 chain A domain 1 Region: 109 - 146 Aligned: 38 Modelled: 38 Confidence: 6.0% Identity: 18% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 1 d1s9ua_ 2 d1n1ca_ 3 c2o9xA_ 4 d2o9xa1 5 d2idga1 6 c3bf2A_ 7 c2zopA_ 8 d1ysga1 9 d1q8ha_ 10 c1q8hA_ 11 c3qbrA_ 12 d1f16a_ 13 d2ponb1 14 d1g5ma_ 15 d1pq1a_ 16 c2vofA_ 17 d1q3ma_ 18 d1rutx2 19 d1m3va2 20 d1zy3a1 21 22 23

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1s9ua_ 100.0 32 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 2 d1n1ca_ 100.0 19 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 3 c2o9xA_ 100.0 24 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus 4 d2o9xa1 100.0 23 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 5 d2idga1 99.8 19 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 6 c3bf2A_ 22.3 26 PDB header:lipoprotein Chain: A: PDB Molecule:putative lipoprotein; PDBTitle: crystal structure of the a1ksw9_neimf protein from2 neisseria meningitidis. northeast structural genomics3 consortium target mr36a 7 c2zopA_ 14.4 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein tthb164; PDBTitle: x-ray crystal structure of a crispr-associated cmr5 family2 protein from thermus thermophilus hb8 8 d1ysga1 13.3 21 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 9 d1q8ha_ 9.6 56 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 10 c1q8hA_ 9.6 56 PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin 11 c3qbrA_ 9.1 14 PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja 12 d1f16a_ 8.5 24 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 13 d2ponb1 8.5 21 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 14 d1g5ma_ 7.5 14 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 15 d1pq1a_ 7.3 21 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 16 c2vofA_ 7.1 13 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain 17 d1q3ma_ 6.9 56 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 18 d1rutx2 6.4 50 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 19 d1m3va2 6.2 50 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 20 d1zy3a1 6.0 18 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 21 d2jm6b1 not modelled 5.9 18 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 22 c2o2fA_ not modelled 5.9 13 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand 23 c2xa0A_ not modelled 5.5 13 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: crystal structure of bcl-2 in complex with a bax bh32 peptide

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0