Secondary structure and disorder prediction

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Sequence		M	S	K	V	C	I	I	A	W	V	Y	G	R	V	Q	G	V	G	F	R	Y	T	T	Q	Y	E	A	K	R	L	G	L	T	G	Y	A	K	N	L	D	D	G	S	V	E	V	V	A	C	G	E	E	G	Q	V	E	K	L	M	Q
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.
Sequence		W	L	K	S	G	G	P	R	S	A	R	V	E	R	V	L	S	E	P	H	H	P	S	G	E	L	T	D	F	R	I	R
Secondary structure
SS confidence
Disorder																										?	?	?	?	?		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2gv1 chain A Region: 1 - 92 Aligned: 92 Modelled: 92 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:probable acylphosphatase; PDBTitle: nmr solution structure of the acylphosphatase from2 eschaerichia coli Phyre2 PDB 3br8 chain A Region: 1 - 92 Aligned: 89 Modelled: 92 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:probable acylphosphatase; PDBTitle: crystal structure of acylphosphatase from bacillus subtilis Phyre2 PDB 2bje chain A Region: 1 - 91 Aligned: 88 Modelled: 91 Confidence: 100.0% Identity: 51% PDB header:hydrolase Chain: A: PDB Molecule:acylphosphatase; PDBTitle: acylphosphatase from sulfolobus solfataricus. monclinic p212 space group Phyre2 PDB 2acy chain A Region: 1 - 92 Aligned: 92 Modelled: 92 Confidence: 100.0% Identity: 32% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1urr chain A Region: 4 - 92 Aligned: 89 Modelled: 89 Confidence: 100.0% Identity: 30% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1w2i chain A Region: 2 - 92 Aligned: 89 Modelled: 91 Confidence: 100.0% Identity: 48% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1aps chain A Region: 4 - 92 Aligned: 89 Modelled: 89 Confidence: 100.0% Identity: 33% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1ulr chain A Region: 5 - 91 Aligned: 85 Modelled: 87 Confidence: 100.0% Identity: 49% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 1gxu chain A Region: 2 - 92 Aligned: 87 Modelled: 91 Confidence: 100.0% Identity: 36% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: Acylphosphatase-like Phyre2 PDB 2bun chain A domain 1 Region: 23 - 92 Aligned: 67 Modelled: 70 Confidence: 91.2% Identity: 19% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: BLUF domain Phyre2 PDB 1yrx chain A domain 1 Region: 23 - 92 Aligned: 67 Modelled: 70 Confidence: 90.6% Identity: 21% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: BLUF domain Phyre2 PDB 2hfn chain J Region: 23 - 92 Aligned: 67 Modelled: 70 Confidence: 89.6% Identity: 16% PDB header:electron transport Chain: J: PDB Molecule:synechocystis photoreceptor (slr1694); PDBTitle: crystal structures of the synechocystis photoreceptor slr1694 reveal2 distinct structural states related to signaling Phyre2 PDB 2kb2 chain A Region: 23 - 92 Aligned: 67 Modelled: 70 Confidence: 89.5% Identity: 21% PDB header:signaling protein, hydrolase regulator Chain: A: PDB Molecule:blrp1; PDBTitle: blrp1 bluf Phyre2 PDB 2byc chain A domain 1 Region: 23 - 90 Aligned: 65 Modelled: 68 Confidence: 88.1% Identity: 18% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: BLUF domain Phyre2 PDB 1x0p chain A domain 1 Region: 23 - 92 Aligned: 67 Modelled: 70 Confidence: 87.5% Identity: 18% Fold: Ferredoxin-like Superfamily: Acylphosphatase/BLUF domain-like Family: BLUF domain Phyre2 PDB 2xzn chain F Region: 9 - 72 Aligned: 64 Modelled: 64 Confidence: 85.8% Identity: 14% PDB header:ribosome Chain: F: PDB Molecule:eif1; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 2 Phyre2 PDB 2qsw chain A domain 1 Region: 21 - 66 Aligned: 46 Modelled: 46 Confidence: 85.4% Identity: 15% Fold: Ferredoxin-like Superfamily: ACT-like Family: NIL domain-like Phyre2 PDB 2ogh chain A Region: 9 - 72 Aligned: 64 Modelled: 64 Confidence: 81.2% Identity: 11% PDB header:translation Chain: A: PDB Molecule:eukaryotic translation initiation factor eif-1; PDBTitle: solution structure of yeast eif1 Phyre2 PDB 2if1 chain A Region: 9 - 72 Aligned: 64 Modelled: 64 Confidence: 79.7% Identity: 9% Fold: eIF1-like Superfamily: eIF1-like Family: eIF1-like Phyre2 PDB 2f1f chain A domain 2 Region: 20 - 64 Aligned: 43 Modelled: 45 Confidence: 78.2% Identity: 12% Fold: Ferredoxin-like Superfamily: ACT-like Family: IlvH-like Phyre2 1 c2gv1A_ 2 c3br8A_ 3 c2bjeA_ 4 d2acya_ 5 d1urra_ 6 d1w2ia_ 7 d1apsa_ 8 d1ulra_ 9 d1gxua_ 10 d2buna1 11 d1yrxa1 12 c2hfnJ_ 13 c2kb2A_ 14 d2byca1 15 d1x0pa1 16 c2xznF_ 17 d2qswa1 18 c2oghA_ 19 d2if1a_ 20 d2f1fa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2gv1A_ 100.0 100 PDB header:hydrolase Chain: A: PDB Molecule:probable acylphosphatase; PDBTitle: nmr solution structure of the acylphosphatase from2 eschaerichia coli 2 c3br8A_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:probable acylphosphatase; PDBTitle: crystal structure of acylphosphatase from bacillus subtilis 3 c2bjeA_ 100.0 51 PDB header:hydrolase Chain: A: PDB Molecule:acylphosphatase; PDBTitle: acylphosphatase from sulfolobus solfataricus. monclinic p212 space group 4 d2acya_ 100.0 32 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 5 d1urra_ 100.0 30 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 6 d1w2ia_ 100.0 48 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 7 d1apsa_ 100.0 33 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 8 d1ulra_ 100.0 49 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 9 d1gxua_ 100.0 36 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:Acylphosphatase-like 10 d2buna1 91.2 19 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 11 d1yrxa1 90.6 21 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 12 c2hfnJ_ 89.6 16 PDB header:electron transport Chain: J: PDB Molecule:synechocystis photoreceptor (slr1694); PDBTitle: crystal structures of the synechocystis photoreceptor slr1694 reveal2 distinct structural states related to signaling 13 c2kb2A_ 89.5 21 PDB header:signaling protein, hydrolase regulator Chain: A: PDB Molecule:blrp1; PDBTitle: blrp1 bluf 14 d2byca1 88.1 18 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 15 d1x0pa1 87.5 18 Fold:Ferredoxin-like Superfamily:Acylphosphatase/BLUF domain-like Family:BLUF domain 16 c2xznF_ 85.8 14 PDB header:ribosome Chain: F: PDB Molecule:eif1; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 2 17 d2qswa1 85.4 15 Fold:Ferredoxin-like Superfamily:ACT-like Family:NIL domain-like 18 c2oghA_ 81.2 11 PDB header:translation Chain: A: PDB Molecule:eukaryotic translation initiation factor eif-1; PDBTitle: solution structure of yeast eif1 19 d2if1a_ 79.7 9 Fold:eIF1-like Superfamily:eIF1-like Family:eIF1-like 20 d2f1fa2 78.2 12 Fold:Ferredoxin-like Superfamily:ACT-like Family:IlvH-like 21 d2fgca1 not modelled 76.4 12 Fold:Ferredoxin-like Superfamily:ACT-like Family:IlvH-like 22 d2pc6a1 not modelled 74.9 12 Fold:Ferredoxin-like Superfamily:ACT-like Family:IlvH-like 23 c2fgcA_ not modelled 64.8 12 PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase, small subunit; PDBTitle: crystal structure of acetolactate synthase- small subunit from2 thermotoga maritima 24 c3c5tB_ not modelled 64.5 53 PDB header:signaling protein/signaling protein Chain: B: PDB Molecule:exendin-4; PDBTitle: crystal structure of the ligand-bound glucagon-like peptide-1 receptor2 extracellular domain 25 c2pc6C_ not modelled 61.8 11 PDB header:lyase Chain: C: PDB Molecule:probable acetolactate synthase isozyme iii (small subunit); PDBTitle: crystal structure of putative acetolactate synthase- small subunit2 from nitrosomonas europaea 26 c2f1fA_ not modelled 61.0 12 PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase isozyme iii small subunit; PDBTitle: crystal structure of the regulatory subunit of2 acetohydroxyacid synthase isozyme iii from e. coli 27 c2rjzA_ not modelled 58.3 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pilo protein; PDBTitle: crystal structure of the type 4 fimbrial biogenesis protein pilo from2 pseudomonas aeruginosa 28 d3dhxa1 not modelled 56.6 15 Fold:Ferredoxin-like Superfamily:ACT-like Family:NIL domain-like 29 d2qrra1 not modelled 56.1 13 Fold:Ferredoxin-like Superfamily:ACT-like Family:NIL domain-like 30 d1a0ia1 not modelled 40.6 16 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:DNA ligase/mRNA capping enzyme postcatalytic domain 31 d2zjre1 not modelled 25.1 16 Fold:Ribosomal protein L6 Superfamily:Ribosomal protein L6 Family:Ribosomal protein L6 32 c3fhaD_ not modelled 23.6 18 PDB header:hydrolase Chain: D: PDB Molecule:endo-beta-n-acetylglucosaminidase; PDBTitle: structure of endo-beta-n-acetylglucosaminidase a 33 c2yy3B_ not modelled 22.7 21 PDB header:translation Chain: B: PDB Molecule:elongation factor 1-beta; PDBTitle: crystal structure of translation elongation factor ef-1 beta from2 pyrococcus horikoshii 34 d3ceda1 not modelled 22.6 13 Fold:Ferredoxin-like Superfamily:ACT-like Family:NIL domain-like 35 c2zkre_ not modelled 21.8 11 PDB header:ribosomal protein/rna Chain: E: PDB Molecule:rna expansion segment es7 part ii; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 36 d1fx0a2 not modelled 17.0 36 Fold:Domain of alpha and beta subunits of F1 ATP synthase-like Superfamily:N-terminal domain of alpha and beta subunits of F1 ATP synthase Family:N-terminal domain of alpha and beta subunits of F1 ATP synthase 37 d2jdia2 not modelled 16.0 36 Fold:Domain of alpha and beta subunits of F1 ATP synthase-like Superfamily:N-terminal domain of alpha and beta subunits of F1 ATP synthase Family:N-terminal domain of alpha and beta subunits of F1 ATP synthase 38 c3gwpA_ not modelled 15.9 19 PDB header:lyase Chain: A: PDB Molecule:carbon-sulfur lyase involved in aluminum resistance; PDBTitle: crystal structure of carbon-sulfur lyase involved in aluminum2 resistance (yp_878183.1) from clostridium novyi nt at 2.90 a3 resolution 39 c3ucoB_ not modelled 15.2 18 PDB header:lyase/lyase inhibitor Chain: B: PDB Molecule:carbonic anhydrase; PDBTitle: coccomyxa beta-carbonic anhydrase in complex with iodide 40 c1jrjA_ not modelled 14.3 53 PDB header:hormone/growth factor Chain: A: PDB Molecule:exendin-4; PDBTitle: solution structure of exendin-4 in 30-vol% trifluoroethanol 41 c2dclB_ not modelled 12.8 14 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical upf0166 protein ph1503; PDBTitle: structure of ph1503 protein from pyrococcus horikoshii ot3 42 c2a5vB_ not modelled 12.2 27 PDB header:lyase Chain: B: PDB Molecule:carbonic anhydrase (carbonate dehydratase) (carbonic PDBTitle: crystal structure of m. tuberculosis beta carbonic anhydrase, rv3588c,2 tetrameric form 43 d2cz4a1 not modelled 11.8 19 Fold:Ferredoxin-like Superfamily:GlnB-like Family:Prokaryotic signal transducing protein 44 d1d1ra_ not modelled 11.7 16 Fold:eIF1-like Superfamily:eIF1-like Family:eIF1-like 45 c1d1rA_ not modelled 11.7 16 PDB header:structural genomics Chain: A: PDB Molecule:hypothetical 11.4 kd protein ycih in pyrf-osmb PDBTitle: nmr solution structure of the product of the e. coli ycih2 gene. 46 c2jz2A_ not modelled 10.6 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:ssl0352 protein; PDBTitle: solution nmr structure of ssl0352 protein from synechocystis sp. pcc2 6803. northeast structural genomics consortium target sgr42 47 d1vqoh1 not modelled 8.6 16 Fold:alpha/beta-Hammerhead Superfamily:Ribosomal protein L16p/L10e Family:Ribosomal protein L10e 48 c2qv6D_ not modelled 8.3 10 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 49 d1maba2 not modelled 7.8 36 Fold:Domain of alpha and beta subunits of F1 ATP synthase-like Superfamily:N-terminal domain of alpha and beta subunits of F1 ATP synthase Family:N-terminal domain of alpha and beta subunits of F1 ATP synthase 50 c3eyxB_ not modelled 7.6 25 PDB header:lyase Chain: B: PDB Molecule:carbonic anhydrase; PDBTitle: crystal structure of carbonic anhydrase nce103 from2 saccharomyces cerevisiae 51 d2fyxa1 not modelled 7.5 15 Fold:Ferredoxin-like Superfamily:Transposase IS200-like Family:Transposase IS200-like 52 c3qm2A_ not modelled 7.4 14 PDB header:transferase Chain: A: PDB Molecule:phosphoserine aminotransferase; PDBTitle: 2.25 angstrom crystal structure of phosphoserine aminotransferase2 (serc) from salmonella enterica subsp. enterica serovar typhimurium 53 c1iq8B_ not modelled 7.2 13 PDB header:transferase Chain: B: PDB Molecule:archaeosine trna-guanine transglycosylase; PDBTitle: crystal structure of archaeosine trna-guanine2 transglycosylase from pyrococcus horikoshii 54 d2vjva1 not modelled 7.2 20 Fold:Ferredoxin-like Superfamily:Transposase IS200-like Family:Transposase IS200-like 55 c1vi7A_ not modelled 6.9 9 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yigz; PDBTitle: crystal structure of an hypothetical protein 56 d1nvma1 not modelled 6.8 19 Fold:RuvA C-terminal domain-like Superfamily:post-HMGL domain-like Family:DmpG/LeuA communication domain-like 57 c1d0rA_ not modelled 6.7 27 PDB header:hormone/growth factor Chain: A: PDB Molecule:glucagon-like peptide-1-(7-36)-amide; PDBTitle: solution structure of glucagon-like peptide-1-(7-36)-amide2 in trifluoroethanol/water 58 c3c9gB_ not modelled 6.6 3 PDB header:nucleotide binding protein Chain: B: PDB Molecule:upf0200/upf0201 protein af_1395; PDBTitle: crystal structure of uncharacterized upf0201 protein af_135 59 d1ddza1 not modelled 6.5 19 Fold:Resolvase-like Superfamily:beta-carbonic anhydrase, cab Family:beta-carbonic anhydrase, cab 60 c2zkrh_ not modelled 6.4 16 PDB header:ribosomal protein/rna Chain: H: PDB Molecule:rna expansion segment es12; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 61 d2zgwa1 not modelled 6.3 47 Fold:SH3-like barrel Superfamily:C-terminal domain of transcriptional repressors Family:Biotin repressor (BirA) 62 c3lasA_ not modelled 6.2 31 PDB header:lyase Chain: A: PDB Molecule:putative carbonic anhydrase; PDBTitle: crystal structure of carbonic anhydrase from streptococcus mutans to2 1.4 angstrom resolution 63 d1whra_ not modelled 5.9 14 Fold:IF3-like Superfamily:R3H domain Family:R3H domain 64 c2ldiA_ not modelled 5.9 9 PDB header:hydrolase Chain: A: PDB Molecule:zinc-transporting atpase; PDBTitle: nmr solution structure of ziaan sub mutant 65 c2qz4A_ not modelled 5.8 18 PDB header:hydrolase Chain: A: PDB Molecule:paraplegin; PDBTitle: human paraplegin, aaa domain in complex with adp 66 c2ju5A_ not modelled 5.7 20 PDB header:oxidoreductase Chain: A: PDB Molecule:thioredoxin disulfide isomerase; PDBTitle: dsbh oxidoreductase 67 c2a8cE_ not modelled 5.6 24 PDB header:lyase Chain: E: PDB Molecule:carbonic anhydrase 2; PDBTitle: haemophilus influenzae beta-carbonic anhydrase 68 d1ddza2 not modelled 5.5 20 Fold:Resolvase-like Superfamily:beta-carbonic anhydrase, cab Family:beta-carbonic anhydrase, cab 69 d2hh8a1 not modelled 5.4 26 Fold:YdfO-like Superfamily:YdfO-like Family:YdfO-like 70 d1skyb2 not modelled 5.3 33 Fold:Domain of alpha and beta subunits of F1 ATP synthase-like Superfamily:N-terminal domain of alpha and beta subunits of F1 ATP synthase Family:N-terminal domain of alpha and beta subunits of F1 ATP synthase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0