Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	H	F	S	Q	Q	D	N	F	S	V	A	A	R	V	L	G	A	L	F	Y	Y	A	P	E	S	A	E	A	A	P	L	V	A	V	L	T	S	D	G	W	E	T	Q	W	P	L	P	E	A	S	L	A	P	L	V	T	A	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	T	Q	C	E	E	T	H	A	Q	A	W	Q	R	L	F	V	G	P	W	A	L	P	S	P	P	W	G	S	V	W	L	D	R	E	S	V	L	F	G	D	S	T	L	A	L	R	Q	W	M	R	E	K	G	I	Q	F	E	M	K
Secondary structure
SS confidence
Disorder																																																											?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	N	E	P	E	D	H	F	G	S	L	L	L	M	A	A	W	L	A	E	N	G	R	Q	T	E	C	E	E	L	L	A	W	H	L	F	P	W	S	T	R	F	L	D	V	F	I	E	K	A	E	H	P	F	Y	R	A	L	G	E
Secondary structure
SS confidence
Disorder		?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.
Sequence		L	A	R	L	T	L	A	Q	W	Q	S	Q	L	L	I	P	V	A	V	K	P	L	F	R
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1s9u chain A Region: 6 - 204 Aligned: 193 Modelled: 199 Confidence: 100.0% Identity: 76% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 1n1c chain A Region: 4 - 194 Aligned: 185 Modelled: 191 Confidence: 100.0% Identity: 17% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2o9x chain A Region: 7 - 187 Aligned: 154 Modelled: 179 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus Phyre2 PDB 2o9x chain A domain 1 Region: 13 - 188 Aligned: 149 Modelled: 174 Confidence: 100.0% Identity: 21% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2idg chain A domain 1 Region: 106 - 182 Aligned: 74 Modelled: 76 Confidence: 99.7% Identity: 19% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 1q8h chain A Region: 117 - 131 Aligned: 15 Modelled: 15 Confidence: 17.2% Identity: 27% PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin Phyre2 PDB 1q8h chain A Region: 117 - 131 Aligned: 15 Modelled: 15 Confidence: 17.2% Identity: 27% Fold: GLA-domain Superfamily: GLA-domain Family: GLA-domain Phyre2 PDB 2r7m chain A Region: 70 - 126 Aligned: 53 Modelled: 57 Confidence: 15.3% Identity: 21% PDB header:ligase Chain: A: PDB Molecule:5-formaminoimidazole-4-carboxamide-1-(beta)-d- PDBTitle: crystal structure of faicar synthetase (purp) from m.2 jannaschii complexed with amp Phyre2 PDB 1m3v chain A domain 2 Region: 69 - 81 Aligned: 13 Modelled: 13 Confidence: 12.2% Identity: 31% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 1q3m chain A Region: 117 - 130 Aligned: 14 Modelled: 14 Confidence: 12.1% Identity: 29% Fold: GLA-domain Superfamily: GLA-domain Family: GLA-domain Phyre2 PDB 1ysg chain A domain 1 Region: 127 - 161 Aligned: 35 Modelled: 35 Confidence: 10.8% Identity: 20% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1yt3 chain A domain 2 Region: 171 - 197 Aligned: 27 Modelled: 27 Confidence: 8.8% Identity: 15% Fold: SAM domain-like Superfamily: HRDC-like Family: RNase D C-terminal domains Phyre2 PDB 1lcd chain A Region: 89 - 119 Aligned: 31 Modelled: 31 Confidence: 8.4% Identity: 13% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: GalR/LacI-like bacterial regulator Phyre2 PDB 2qec chain A Region: 105 - 127 Aligned: 23 Modelled: 23 Confidence: 7.3% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:histone acetyltransferase hpa2 and related PDBTitle: crystal structure of histone acetyltransferase hpa2 and related2 acetyltransferase (np_600742.1) from corynebacterium glutamicum atcc3 13032 at 1.90 a resolution Phyre2 PDB 3qbr chain A Region: 127 - 159 Aligned: 33 Modelled: 33 Confidence: 7.2% Identity: 12% PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja Phyre2 PDB 2pon chain B domain 1 Region: 127 - 161 Aligned: 35 Modelled: 35 Confidence: 6.9% Identity: 20% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1g5m chain A Region: 128 - 161 Aligned: 34 Modelled: 34 Confidence: 6.5% Identity: 15% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1pq1 chain A Region: 127 - 161 Aligned: 35 Modelled: 35 Confidence: 6.0% Identity: 20% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1qpz chain A domain 1 Region: 89 - 118 Aligned: 30 Modelled: 30 Confidence: 5.9% Identity: 10% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: GalR/LacI-like bacterial regulator Phyre2 PDB 1f16 chain A Region: 127 - 161 Aligned: 35 Modelled: 35 Confidence: 5.7% Identity: 20% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 1 d1s9ua_ 2 d1n1ca_ 3 c2o9xA_ 4 d2o9xa1 5 d2idga1 6 c1q8hA_ 7 d1q8ha_ 8 c2r7mA_ 9 d1m3va2 10 d1q3ma_ 11 d1ysga1 12 d1yt3a2 13 d1lcda_ 14 c2qecA_ 15 c3qbrA_ 16 d2ponb1 17 d1g5ma_ 18 d1pq1a_ 19 d1qpza1 20 d1f16a_ 21

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1s9ua_ 100.0 76 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 2 d1n1ca_ 100.0 17 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 3 c2o9xA_ 100.0 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus 4 d2o9xa1 100.0 21 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 5 d2idga1 99.7 19 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 6 c1q8hA_ 17.2 27 PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin 7 d1q8ha_ 17.2 27 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 8 c2r7mA_ 15.3 21 PDB header:ligase Chain: A: PDB Molecule:5-formaminoimidazole-4-carboxamide-1-(beta)-d- PDBTitle: crystal structure of faicar synthetase (purp) from m.2 jannaschii complexed with amp 9 d1m3va2 12.2 31 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 10 d1q3ma_ 12.1 29 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 11 d1ysga1 10.8 20 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 12 d1yt3a2 8.8 15 Fold:SAM domain-like Superfamily:HRDC-like Family:RNase D C-terminal domains 13 d1lcda_ 8.4 13 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:GalR/LacI-like bacterial regulator 14 c2qecA_ 7.3 13 PDB header:transferase Chain: A: PDB Molecule:histone acetyltransferase hpa2 and related PDBTitle: crystal structure of histone acetyltransferase hpa2 and related2 acetyltransferase (np_600742.1) from corynebacterium glutamicum atcc3 13032 at 1.90 a resolution 15 c3qbrA_ 7.2 12 PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja 16 d2ponb1 6.9 20 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 17 d1g5ma_ 6.5 15 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 18 d1pq1a_ 6.0 20 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 19 d1qpza1 5.9 10 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:GalR/LacI-like bacterial regulator 20 d1f16a_ 5.7 20 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 21 c2kngA_ not modelled 5.4 27 PDB header:dna binding protein Chain: A: PDB Molecule:protein lsr2; PDBTitle: solution structure of c-domain of lsr2

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0