Job Description P00892 Confidence 100.00% Date Thu Jan 5 10:57:00 GMT 2012 Rank 22 Aligned Residues 513 % Identity 19% Template c2w93A_ PDB info PDB header:lyase Chain: A: PDB Molecule:pyruvate decarboxylase isozyme 1; PDBTitle: crystal structure of the saccharomyces cerevisiae pyruvate2 decarboxylase variant e477q in complex with the surrogate3 pyruvamide Resolution 1.60 Å

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		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.		.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																							.
Query SS confidence																																							.
Query Sequence		M	N	G	A	Q	W	V	V	H	A	L	R	A	Q	G	V	N	T	V	F	G	Y	P	G	G	A	I	M	P	V	Y	D	A	L	Y	D	G	.	G	V	E	H	L	L	C	R	H	E	Q	G	A	A	M	A	A	I	G	Y	A	R	A	T	G	K	T	G	V	C	I	A	T	S	G	P	G	A	T	N	L	I
Query Conservation																																							.
Alig confidence																																							.																												.
Template Conservation																																																																			.
Template Sequence		I	T	L	G	K	Y	L	F	E	R	L	K	Q	V	N	V	N	T	V	F	G	L	P	G	D	F	N	L	S	L	L	D	K	I	Y	E	V	E	G	M	R	W	A	G	N	A	N	E	L	N	A	A	Y	A	A	D	G	Y	A	R	I	K	G	M	S	.	C	I	I	T	T	F	G	V	G	E	L	S	A	L
Template Known Secondary structure															T	T										G	G	G						G	G	G	G	S	T	T							S																	S			.						T	T
Template Predicted Secondary structure																																																																			.
Template SS confidence
		4	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.		.	70	.	.	.	.	.	.	.	.	.	80	.	.
		80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.									.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Predicted Secondary structure																																		.	.	.	.	.	.	.	.
Query SS confidence																																		.	.	.	.	.	.	.	.
Query Sequence		T	G	L	A	D	A	L	L	D	S	I	P	V	V	A	I	T	G	Q	V	S	A	P	F	I	G	T	D	A	F	Q	E	.	.	.	.	.	.	.	.	V	D	V	L	G	L	S	L	A	C	T	K	H	S	F	L	V	Q	S	L	E	E	L	P	R	I	M	A	E	A	F	D	V	A	C	S	G	R	P	G
Query Conservation																																		.	.	.	.	.	.	.	.
Alig confidence																																		.	.	.	.	.	.	.	.																																							.
Template Conservation																																																																																.
Template Sequence		N	G	I	A	G	S	Y	A	E	H	V	G	V	L	H	V	V	G	V	P	S	I	S	S	Q	A	K	Q	L	L	L	H	H	T	L	G	N	G	D	F	T	V	F	H	R	M	S	A	N	I	S	E	T	T	A	M	I	T	D	I	A	T	A	P	A	E	I	D	R	C	I	R	T	T	Y	V	T	Q	.	R
Template Known Secondary structure										T	T																	T	T				T	T	S		S	S	S		S	S								T	T		S								T	T	T																T	.	S
Template Predicted Secondary structure																																																																																.
Template SS confidence
		83	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160		.
		152	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180						.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.
Predicted Secondary structure																															.	.	.	.	.
Query SS confidence																															.	.	.	.	.
Query Sequence		P	V	L	V	D	I	P	K	D	I	Q	L	A	S	G	D	L	E	P	W	F	T	T	V	E	N	E	V	T	.	.	.	.	.	F	P	H	A	E	V	E	Q	A	R	Q	M	L	A	K	A	Q	K	P	M	L	Y	V	G	G	G	V	G	M	A	Q	A	V	P	A	L	R	E	F	L	A	A	T	K	M	P
Query Conservation																															.	.	.	.	.
Alig confidence																															.	.	.	.	.
Template Conservation
Template Sequence		P	V	Y	L	G	L	P	A	N	L	V	D	L	N	V	P	A	K	L	L	Q	T	P	I	D	M	S	L	K	P	N	D	A	E	S	E	K	E	V	I	D	T	I	L	A	L	V	K	D	A	K	N	P	V	I	L	A	D	A	C	C	S	R	H	D	V	K	A	E	T	K	K	L	I	D	L	T	Q	F	P
Template Known Secondary structure									T	T	G	G	G	S				G	G	G	G	G	S					S																								S	S												T	T
Template Predicted Secondary structure
Template SS confidence
		162	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.
		227	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.		.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.
Predicted Secondary structure																							.
Query SS confidence																							.
Query Sequence		A	T	C	T	L	K	G	L	G	A	V	E	A	D	Y	P	Y	Y	L	G	M	.	L	G	M	H	G	T	K	A	A	N	F	A	V	Q	E	C	D	L	L	I	A	V	G	A	R	F	D	D	R	V	T	G	K	L	N	T	F	A	P	H	A	S	V	I	H	M	D	I	D	P	A	E	M	N	K	L	R	Q
Query Conservation																							.
Alig confidence																							.																												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																																			.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		A	F	V	T	P	M	G	K	G	S	I	D	E	Q	H	P	R	Y	G	G	V	Y	V	G	T	L	S	K	P	E	V	K	E	A	V	E	S	A	D	L	I	L	S	V	G	A	L	T	K	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	I	V	E	F	H	S	D	H	M	K	I	R	N	A	T	F
Template Known Secondary structure						T	T	T	T	T	S	S		T	T	S	T	T							G	G	G	S										T		S						S					.	.	.	.	.	.	.	.	.	.	.	.	.	.							S	S					T	T
Template Predicted Secondary structure																																																			.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		242	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290															.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.
		306	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	H	V	A	L	Q	G	D	L	N	A	L	L	P	A	L	Q	Q	P	L	N	Q	Y	D	W	Q	Q	H	C	A	Q	L	R	D	E	H	S	W	R	Y	D	H	P	G	D	A	I	Y	A	P	L	L	L	K	Q	L	S	D	R	K	P	A	D	C	V	V	T	T	D	V	G	Q	H	Q	M	W	A	A	Q	H
Query Conservation
Alig confidence																															.	.	.
Template Conservation																															.	.	.
Template Sequence		P	G	V	Q	M	K	F	V	L	Q	K	L	L	T	N	I	A	D	A	A	K	G	Y	K	P	V	A	V	P	.	.	.	A	R	T	P	A	N	A	A	V	P	A	S	T	P	L	K	Q	E	W	M	W	N	Q	L	G	N	F	L	Q	E	G	D	V	V	I	A	E	T	G	T	S	A	F	G	I	N	Q	T
Template Known Secondary structure			T																		T	T	T								.	.	.											T	T		B										G	G	G	T			T	T							T	T						G	G	G	S
Template Predicted Secondary structure																															.	.	.
Template SS confidence
		322	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350				.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.
		386	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.					.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Predicted Secondary structure																																.	.	.	.
Query SS confidence																																.	.	.	.
Query Sequence		I	A	H	T	R	P	E	N	F	I	T	S	S	G	L	G	T	M	G	F	G	L	P	A	A	V	G	A	Q	V	.	.	.	.	A	R	P	N	D	T	V	V	C	I	S	G	D	G	S	F	M	M	N	V	Q	E	L	G	T	V	K	R	K	Q	L	P	L	K	I	V	L	L	D	N	Q	R	L	G	M	V
Query Conservation																																.	.	.	.
Alig confidence			.																													.	.	.	.
Template Conservation			.
Template Sequence		T	.	F	P	N	N	T	Y	G	I	S	Q	V	L	W	G	S	I	G	F	T	T	G	A	T	L	G	A	A	F	A	A	E	E	I	D	P	K	K	R	V	I	L	F	I	G	D	G	S	L	Q	L	T	V	Q	E	I	S	T	M	I	R	W	G	L	K	P	Y	L	F	V	L	N	N	D	G	Y	T	I	Q
Template Known Secondary structure			.			S	S							T	T	T			T	T																		T	T																T	T								T	T										S	S	S
Template Predicted Secondary structure			.
Template SS confidence
		399		400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.
		462	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.				.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.			.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.
Predicted Secondary structure																																					.	.	.																	.	.
Query SS confidence																																					.	.	.																	.	.
Query Sequence		R	Q	W	Q	Q	L	F	F	Q	E	R	Y	S	E	T	T	L	T	D	N	P	D	F	L	M	L	A	S	A	F	G	I	H	G	Q	.	.	.	H	I	T	R	K	D	Q	V	E	A	A	L	D	T	M	L	.	.	N	S	D	G	P	Y	L	L	H	V	S	I	D	E	L	E	N	V	W	P	L	V	P	P
Query Conservation																																					.	.	.																	.	.
Alig confidence						.	.	.	.	.																											.	.	.																	.	.
Template Conservation						.	.	.	.	.
Template Sequence		K	L	I	H	.	.	.	.	.	G	P	K	A	Q	Y	N	E	I	Q	G	W	D	H	L	S	L	L	P	T	F	G	A	K	D	Y	E	T	H	R	V	A	T	T	G	E	W	D	K	L	T	Q	D	K	S	F	N	D	N	S	K	I	R	M	I	E	V	M	L	P	V	F	D	A	P	Q	N	L	V	E	Q
Template Known Secondary structure			T	T	S	.	.	.	.	.		T	T		G	G	G							G	G	G					T	T		S	S								B									T		T	T	T	T	S			S										T	T
Template Predicted Secondary structure						.	.	.	.	.
Template SS confidence
		478	.	480	.						.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.
		537	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	K
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		553	.