Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	S	K	D	T	L	K	W	F	P	A	Q	L	P	E	V	R	I	I	L	G	D	A	V	V	E	V	A	K	Q	G	R	P	I	N	T	R	T	L	L	D	Y	I	E	G	N	I	K	K	K	S	W	L	D	N	K	E	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																							?		?																?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.
Sequence		Q	T	A	I	S	V	L	K	D	N	Q	N	L	N	G	K	M
Secondary structure
SS confidence
Disorder									?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2kk1 chain A Region: 24 - 70 Aligned: 39 Modelled: 47 Confidence: 36.9% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase abl2; PDBTitle: solution structure of c-terminal domain of tyrosine-protein2 kinase abl2 from homo sapiens, northeast structural3 genomics consortium (nesg) target hr5537a Phyre2 PDB 1zzp chain A Region: 24 - 70 Aligned: 39 Modelled: 47 Confidence: 25.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1; PDBTitle: solution structure of the f-actin binding domain of bcr-2 abl/c-abl Phyre2 PDB 1a11 chain A Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 24.1% Identity: 70% PDB header:acetylcholine receptor Chain: A: PDB Molecule:acetylcholine receptor m2; PDBTitle: nmr structure of membrane spanning segment 2 of the2 acetylcholine receptor in dpc micelles, 10 structures Phyre2 PDB 1eq8 chain C Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 19.7% Identity: 70% PDB header:signaling protein Chain: C: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain D Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 19.7% Identity: 70% PDB header:signaling protein Chain: D: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain A Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 19.7% Identity: 70% PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain E Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 19.7% Identity: 70% PDB header:signaling protein Chain: E: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain B Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 19.7% Identity: 70% PDB header:signaling protein Chain: B: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1wq6 chain A Region: 36 - 72 Aligned: 28 Modelled: 37 Confidence: 17.5% Identity: 25% PDB header:oncoprotein Chain: A: PDB Molecule:aml1-eto; PDBTitle: the tetramer structure of the nervy homolgy two (nhr2) domain of aml1-2 eto is critical for aml1-eto's activity Phyre2 PDB 1m5q chain 1 Region: 19 - 45 Aligned: 27 Modelled: 27 Confidence: 11.0% Identity: 22% Fold: Sm-like fold Superfamily: Sm-like ribonucleoproteins Family: Sm motif of small nuclear ribonucleoproteins, SNRNP Phyre2 PDB 2fna chain A domain 1 Region: 29 - 49 Aligned: 21 Modelled: 21 Confidence: 9.4% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Helicase DNA-binding domain Phyre2 PDB 3e0z chain B Region: 35 - 58 Aligned: 24 Modelled: 23 Confidence: 7.3% Identity: 29% PDB header:unknown function Chain: B: PDB Molecule:protein of unknown function; PDBTitle: crystal structure of a putative imidazole glycerol phosphate synthase2 homolog (eubrec_1070) from eubacterium rectale at 1.75 a resolution Phyre2 PDB 3nbm chain A Region: 15 - 55 Aligned: 41 Modelled: 41 Confidence: 6.2% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:pts system, lactose-specific iibc components; PDBTitle: the lactose-specific iib component domain structure of the2 phosphoenolpyruvate:carbohydrate phosphotransferase system (pts) from3 streptococcus pneumoniae. Phyre2 PDB 1izl chain J Region: 31 - 37 Aligned: 7 Modelled: 7 Confidence: 6.2% Identity: 57% PDB header:photosynthesis Chain: J: PDB Molecule:photosystem ii: subunit psba; PDBTitle: crystal structure of photosystem ii Phyre2 PDB 3blh chain B domain 1 Region: 38 - 69 Aligned: 26 Modelled: 32 Confidence: 5.7% Identity: 15% Fold: Cyclin-like Superfamily: Cyclin-like Family: Cyclin Phyre2 PDB 1mu2 chain A Region: 12 - 50 Aligned: 38 Modelled: 39 Confidence: 5.7% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:hiv-2 rt; PDBTitle: crystal structure of hiv-2 reverse transcriptase Phyre2 PDB 3ctd chain B Region: 14 - 29 Aligned: 16 Modelled: 16 Confidence: 5.7% Identity: 31% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative atpase, aaa family; PDBTitle: crystal structure of a putative aaa family atpase from2 prochlorococcus marinus subsp. pastoris Phyre2 PDB 1dfw chain A Region: 38 - 50 Aligned: 13 Modelled: 13 Confidence: 5.7% Identity: 38% PDB header:immune system Chain: A: PDB Molecule:lung surfactant protein b; PDBTitle: conformational mapping of the n-terminal segment of2 surfactant protein b in lipid using 13c-enhanced fourier3 transform infrared spectroscopy (ftir) Phyre2 PDB 1wn4 chain A Region: 20 - 32 Aligned: 13 Modelled: 13 Confidence: 5.5% Identity: 46% PDB header:plant protein Chain: A: PDB Molecule:vontr protein; PDBTitle: nmr structure of vontr Phyre2 PDB 2r5u chain D Region: 23 - 47 Aligned: 25 Modelled: 25 Confidence: 5.4% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:replicative dna helicase; PDBTitle: crystal structure of the n-terminal domain of dnab helicase from2 mycobacterium tuberculosis Phyre2 1 c2kk1A_ 2 c1zzpA_ 3 c1a11A_ 4 c1eq8C_ 5 c1eq8D_ 6 c1eq8A_ 7 c1eq8E_ 8 c1eq8B_ 9 c1wq6A_ 10 d1m5q1_ 11 d2fnaa1 12 c3e0zB_ 13 c3nbmA_ 14 c1izlJ_ 15 d3blhb1 16 c1mu2A_ 17 c3ctdB_ 18 c1dfwA_ 19 c1wn4A_ 20 c2r5uD_ 21 22 23 24 25 26 27

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2kk1A_ 36.9 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase abl2; PDBTitle: solution structure of c-terminal domain of tyrosine-protein2 kinase abl2 from homo sapiens, northeast structural3 genomics consortium (nesg) target hr5537a 2 c1zzpA_ 25.0 31 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1; PDBTitle: solution structure of the f-actin binding domain of bcr-2 abl/c-abl 3 c1a11A_ 24.1 70 PDB header:acetylcholine receptor Chain: A: PDB Molecule:acetylcholine receptor m2; PDBTitle: nmr structure of membrane spanning segment 2 of the2 acetylcholine receptor in dpc micelles, 10 structures 4 c1eq8C_ 19.7 70 PDB header:signaling protein Chain: C: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 5 c1eq8D_ 19.7 70 PDB header:signaling protein Chain: D: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 6 c1eq8A_ 19.7 70 PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 7 c1eq8E_ 19.7 70 PDB header:signaling protein Chain: E: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 8 c1eq8B_ 19.7 70 PDB header:signaling protein Chain: B: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 9 c1wq6A_ 17.5 25 PDB header:oncoprotein Chain: A: PDB Molecule:aml1-eto; PDBTitle: the tetramer structure of the nervy homolgy two (nhr2) domain of aml1-2 eto is critical for aml1-eto's activity 10 d1m5q1_ 11.0 22 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Sm motif of small nuclear ribonucleoproteins, SNRNP 11 d2fnaa1 9.4 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Helicase DNA-binding domain 12 c3e0zB_ 7.3 29 PDB header:unknown function Chain: B: PDB Molecule:protein of unknown function; PDBTitle: crystal structure of a putative imidazole glycerol phosphate synthase2 homolog (eubrec_1070) from eubacterium rectale at 1.75 a resolution 13 c3nbmA_ 6.2 22 PDB header:transferase Chain: A: PDB Molecule:pts system, lactose-specific iibc components; PDBTitle: the lactose-specific iib component domain structure of the2 phosphoenolpyruvate:carbohydrate phosphotransferase system (pts) from3 streptococcus pneumoniae. 14 c1izlJ_ 6.2 57 PDB header:photosynthesis Chain: J: PDB Molecule:photosystem ii: subunit psba; PDBTitle: crystal structure of photosystem ii 15 d3blhb1 5.7 15 Fold:Cyclin-like Superfamily:Cyclin-like Family:Cyclin 16 c1mu2A_ 5.7 16 PDB header:transferase Chain: A: PDB Molecule:hiv-2 rt; PDBTitle: crystal structure of hiv-2 reverse transcriptase 17 c3ctdB_ 5.7 31 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative atpase, aaa family; PDBTitle: crystal structure of a putative aaa family atpase from2 prochlorococcus marinus subsp. pastoris 18 c1dfwA_ 5.7 38 PDB header:immune system Chain: A: PDB Molecule:lung surfactant protein b; PDBTitle: conformational mapping of the n-terminal segment of2 surfactant protein b in lipid using 13c-enhanced fourier3 transform infrared spectroscopy (ftir) 19 c1wn4A_ 5.5 46 PDB header:plant protein Chain: A: PDB Molecule:vontr protein; PDBTitle: nmr structure of vontr 20 c2r5uD_ 5.4 20 PDB header:hydrolase Chain: D: PDB Molecule:replicative dna helicase; PDBTitle: crystal structure of the n-terminal domain of dnab helicase from2 mycobacterium tuberculosis 21 d2ivxa2 not modelled 5.3 15 Fold:Cyclin-like Superfamily:Cyclin-like Family:Cyclin 22 d1b79a_ not modelled 5.2 26 Fold:N-terminal domain of DnaB helicase Superfamily:N-terminal domain of DnaB helicase Family:N-terminal domain of DnaB helicase 23 c2k37A_ not modelled 5.2 14 PDB header:photosynthesis Chain: A: PDB Molecule:chlorosome protein a; PDBTitle: csma 24 d2axta1 not modelled 5.1 57 Fold:Bacterial photosystem II reaction centre, L and M subunits Superfamily:Bacterial photosystem II reaction centre, L and M subunits Family:Bacterial photosystem II reaction centre, L and M subunits 25 c3k13A_ not modelled 5.1 18 PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydrofolate-homocysteine methyltransferase; PDBTitle: structure of the pterin-binding domain metr of 5-2 methyltetrahydrofolate-homocysteine methyltransferase from3 bacteroides thetaiotaomicron 26 d3ctda1 not modelled 5.1 31 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:MgsA/YrvN C-terminal domain-like 27 c1cekA_ not modelled 5.0 100 PDB header:acetylcholine receptor Chain: A: PDB Molecule:protein (acetylcholine receptor m2); PDBTitle: three-dimensional structure of the membrane-embedded m22 channel-lining segment from the nicotinic acetylcholine3 receptor by solid-state nmr spectroscopy

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0