Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	H	L	H	R	F	F	S	S	D	A	S	G	G	I	I	L	I	I	A	A	I	L	A	M	I	M	A	N	S	G	A	T	S	G	W	Y	H	D	F	L	E	T	P	V	Q	L	R	V	G	S	L	E	I	N	K	N	M	L
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	W	I	N	D	A	L	M	A	V	F	F	L	L	V	G	L	E	V	K	R	E	L	M	Q	G	S	L	A	S	L	R	Q	A	A	F	P	V	I	A	A	I	G	G	M	I	V	P	A	L	L	Y	L	A	F	N	Y	A	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	T	R	E	G	W	A	I	P	A	A	T	D	I	A	F	A	L	G	V	L	A	L	L	G	S	R	V	P	L	A	L	K	I	F	L	M	A	L	A	I	I	D	D	L	G	A	I	I	I	I	A	L	F	Y	T	N	D	L	S
Secondary structure
SS confidence
Disorder																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	A	S	L	G	V	A	A	V	A	I	A	V	L	A	V	L	N	L	C	G	A	R	R	T	G	V	Y	I	L	V	G	V	V	L	W	T	A	V	L	K	S	G	V	H	A	T	L	A	G	V	I	V	G	F	F	I	P	L	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	K	H	G	R	S	P	A	K	R	L	E	H	V	L	H	P	W	V	A	Y	L	I	L	P	L	F	A	F	A	N	A	G	V	S	L	Q	G	V	T	L	D	G	L	T	S	I	L	P	L	G	I	I	A	G	L	L	I	G	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	L	G	I	S	L	F	C	W	L	A	L	R	L	K	L	A	H	L	P	E	G	T	T	Y	Q	Q	I	M	V	V	G	I	L	C	G	I	G	F	T	M	S	I	F	I	A	S	L	A	F	G	S	V	D	P	E	L	I	N	W
Secondary structure
SS confidence
Disorder															?		?	?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.
Sequence		A	K	L	G	I	L	V	G	S	I	S	S	A	V	I	G	Y	S	W	L	R	V	R	L	R	P	S	V
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zcd chain A Region: 9 - 384 Aligned: 376 Modelled: 376 Confidence: 100.0% Identity: 100% PDB header:membrane protein Chain: A: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: crystal structure of the na+/h+ antiporter nhaa Phyre2 PDB 2l0e chain A Region: 121 - 144 Aligned: 24 Modelled: 24 Confidence: 10.5% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: structural and functional analysis of tm vi of the nhe1 isoform of the2 na+/h+ exchanger Phyre2 1 c1zcdA_ 2 c2l0eA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1zcdA_ 100.0 100 PDB header:membrane protein Chain: A: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: crystal structure of the na+/h+ antiporter nhaa 2 c2l0eA_ 10.5 21 PDB header:membrane protein Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: structural and functional analysis of tm vi of the nhe1 isoform of the2 na+/h+ exchanger

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0