Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	L	K	A	T	I	Y	K	A	T	V	N	V	A	D	L	D	R	N	Q	F	L	D	A	S	L	T	L	A	R	H	P	S	E	T	Q	E	R	M	M	L	R	L	L	A	W	L	K	Y	A	D	E	R	L	Q	F	T	R	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	C	A	D	D	E	P	E	A	W	L	R	N	D	H	L	G	I	D	L	W	I	E	L	G	L	P	D	E	R	R	I	K	K	A	C	T	Q	A	A	E	V	A	L	F	T	Y	N	S	R	A	A	Q	I	W	W	Q	Q	N	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	K	C	V	Q	F	A	N	L	S	V	W	Y	L	D	D	E	Q	L	A	K	V	S	A	F	A	D	R	T	M	T	L	Q	A	T	I	Q	D	G	V	I	W	L	S	D	D	K	N	N	L	E	V	N	L	T	A	W	Q	Q	P
Secondary structure
SS confidence
Disorder				?	?																						?																														?	?	?	?	?
Disorder confidence
		.
Sequence		S
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2g3w chain A domain 1 Region: 4 - 181 Aligned: 178 Modelled: 178 Confidence: 100.0% Identity: 38% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: YaeQ-like Phyre2 PDB 3c0u chain A Region: 1 - 180 Aligned: 176 Modelled: 180 Confidence: 100.0% Identity: 98% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yaeq; PDBTitle: crystal structure of e.coli yaeq protein Phyre2 PDB 2ot9 chain A domain 1 Region: 2 - 178 Aligned: 175 Modelled: 177 Confidence: 100.0% Identity: 31% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: YaeQ-like Phyre2 PDB 3sft chain A Region: 131 - 173 Aligned: 43 Modelled: 43 Confidence: 33.8% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:chemotaxis response regulator protein-glutamate PDBTitle: crystal structure of thermotoga maritima cheb methylesterase catalytic2 domain Phyre2 PDB 2sh1 chain A Region: 62 - 81 Aligned: 20 Modelled: 20 Confidence: 32.1% Identity: 25% Fold: Defensin-like Superfamily: Defensin-like Family: Defensin Phyre2 PDB 2csu chain A domain 2 Region: 51 - 115 Aligned: 63 Modelled: 65 Confidence: 27.8% Identity: 14% Fold: Flavodoxin-like Superfamily: Succinyl-CoA synthetase domains Family: Succinyl-CoA synthetase domains Phyre2 PDB 1chd chain A Region: 131 - 173 Aligned: 43 Modelled: 43 Confidence: 24.0% Identity: 7% Fold: Methylesterase CheB, C-terminal domain Superfamily: Methylesterase CheB, C-terminal domain Family: Methylesterase CheB, C-terminal domain Phyre2 PDB 3be3 chain A Region: 27 - 42 Aligned: 15 Modelled: 16 Confidence: 23.5% Identity: 47% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein belonging to pfam duf16532 from bordetella bronchiseptica Phyre2 PDB 3pu5 chain A Region: 98 - 146 Aligned: 49 Modelled: 49 Confidence: 21.0% Identity: 4% PDB header:transport protein Chain: A: PDB Molecule:extracellular solute-binding protein; PDBTitle: the crystal structure of a putative extracellular solute-binding2 protein from bordetella parapertussis Phyre2 PDB 1a2o chain B Region: 129 - 173 Aligned: 45 Modelled: 45 Confidence: 19.2% Identity: 4% PDB header:bacterial chemotaxis Chain: B: PDB Molecule:cheb methylesterase; PDBTitle: structural basis for methylesterase cheb regulation by a2 phosphorylation-activated domain Phyre2 PDB 1uar chain A Region: 88 - 132 Aligned: 43 Modelled: 43 Confidence: 16.0% Identity: 7% PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: crystal structure of rhodanese from thermus thermophilus hb8 Phyre2 PDB 1qvp chain A Region: 124 - 172 Aligned: 49 Modelled: 49 Confidence: 13.8% Identity: 16% Fold: SH3-like barrel Superfamily: C-terminal domain of transcriptional repressors Family: FeoA-like Phyre2 PDB 1ekq chain A Region: 80 - 173 Aligned: 94 Modelled: 94 Confidence: 13.6% Identity: 12% Fold: Ribokinase-like Superfamily: Ribokinase-like Family: Thiamin biosynthesis kinases Phyre2 PDB 3hzu chain A Region: 90 - 132 Aligned: 42 Modelled: 43 Confidence: 11.6% Identity: 7% PDB header:transferase Chain: A: PDB Molecule:thiosulfate sulfurtransferase ssea; PDBTitle: crystal structure of probable thiosulfate sulfurtransferase ssea2 (rhodanese) from mycobacterium tuberculosis Phyre2 PDB 1e0c chain A Region: 89 - 132 Aligned: 41 Modelled: 44 Confidence: 11.3% Identity: 12% PDB header:sulfurtransferase Chain: A: PDB Molecule:sulfurtransferase; PDBTitle: sulfurtransferase from azotobacter vinelandii Phyre2 PDB 1urh chain A domain 2 Region: 89 - 132 Aligned: 42 Modelled: 44 Confidence: 11.0% Identity: 5% Fold: Rhodanese/Cell cycle control phosphatase Superfamily: Rhodanese/Cell cycle control phosphatase Family: Multidomain sulfurtransferase (rhodanese) Phyre2 PDB 3aax chain B Region: 88 - 132 Aligned: 44 Modelled: 45 Confidence: 10.9% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:putative thiosulfate sulfurtransferase; PDBTitle: crystal structure of probable thiosulfate sulfurtransferase2 cysa3 (rv3117) from mycobacterium tuberculosis: monoclinic3 form Phyre2 PDB 1urh chain A Region: 89 - 132 Aligned: 42 Modelled: 44 Confidence: 10.7% Identity: 5% PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: the "rhodanese" fold and catalytic mechanism of2 3-mercaptopyruvate sulfotransferases: crystal structure3 of ssea from escherichia coli Phyre2 PDB 2p10 chain D Region: 27 - 109 Aligned: 62 Modelled: 64 Confidence: 10.0% Identity: 23% PDB header:hydrolase Chain: D: PDB Molecule:mll9387 protein; PDBTitle: crystal structure of a putative phosphonopyruvate hydrolase (mll9387)2 from mesorhizobium loti maff303099 at 2.15 a resolution Phyre2 PDB 3olh chain A Region: 98 - 132 Aligned: 33 Modelled: 35 Confidence: 9.9% Identity: 3% PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: human 3-mercaptopyruvate sulfurtransferase Phyre2 1 d2g3wa1 2 c3c0uA_ 3 d2ot9a1 4 c3sftA_ 5 d2sh1a_ 6 d2csua2 7 d1chda_ 8 c3be3A_ 9 c3pu5A_ 10 c1a2oB_ 11 c1uarA_ 12 d1qvpa_ 13 d1ekqa_ 14 c3hzuA_ 15 c1e0cA_ 16 d1urha2 17 c3aaxB_ 18 c1urhA_ 19 c2p10D_ 20 c3olhA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2g3wa1 100.0 38 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:YaeQ-like 2 c3c0uA_ 100.0 98 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yaeq; PDBTitle: crystal structure of e.coli yaeq protein 3 d2ot9a1 100.0 31 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:YaeQ-like 4 c3sftA_ 33.8 16 PDB header:hydrolase Chain: A: PDB Molecule:chemotaxis response regulator protein-glutamate PDBTitle: crystal structure of thermotoga maritima cheb methylesterase catalytic2 domain 5 d2sh1a_ 32.1 25 Fold:Defensin-like Superfamily:Defensin-like Family:Defensin 6 d2csua2 27.8 14 Fold:Flavodoxin-like Superfamily:Succinyl-CoA synthetase domains Family:Succinyl-CoA synthetase domains 7 d1chda_ 24.0 7 Fold:Methylesterase CheB, C-terminal domain Superfamily:Methylesterase CheB, C-terminal domain Family:Methylesterase CheB, C-terminal domain 8 c3be3A_ 23.5 47 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein belonging to pfam duf16532 from bordetella bronchiseptica 9 c3pu5A_ 21.0 4 PDB header:transport protein Chain: A: PDB Molecule:extracellular solute-binding protein; PDBTitle: the crystal structure of a putative extracellular solute-binding2 protein from bordetella parapertussis 10 c1a2oB_ 19.2 4 PDB header:bacterial chemotaxis Chain: B: PDB Molecule:cheb methylesterase; PDBTitle: structural basis for methylesterase cheb regulation by a2 phosphorylation-activated domain 11 c1uarA_ 16.0 7 PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: crystal structure of rhodanese from thermus thermophilus hb8 12 d1qvpa_ 13.8 16 Fold:SH3-like barrel Superfamily:C-terminal domain of transcriptional repressors Family:FeoA-like 13 d1ekqa_ 13.6 12 Fold:Ribokinase-like Superfamily:Ribokinase-like Family:Thiamin biosynthesis kinases 14 c3hzuA_ 11.6 7 PDB header:transferase Chain: A: PDB Molecule:thiosulfate sulfurtransferase ssea; PDBTitle: crystal structure of probable thiosulfate sulfurtransferase ssea2 (rhodanese) from mycobacterium tuberculosis 15 c1e0cA_ 11.3 12 PDB header:sulfurtransferase Chain: A: PDB Molecule:sulfurtransferase; PDBTitle: sulfurtransferase from azotobacter vinelandii 16 d1urha2 11.0 5 Fold:Rhodanese/Cell cycle control phosphatase Superfamily:Rhodanese/Cell cycle control phosphatase Family:Multidomain sulfurtransferase (rhodanese) 17 c3aaxB_ 10.9 14 PDB header:transferase Chain: B: PDB Molecule:putative thiosulfate sulfurtransferase; PDBTitle: crystal structure of probable thiosulfate sulfurtransferase2 cysa3 (rv3117) from mycobacterium tuberculosis: monoclinic3 form 18 c1urhA_ 10.7 5 PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: the "rhodanese" fold and catalytic mechanism of2 3-mercaptopyruvate sulfotransferases: crystal structure3 of ssea from escherichia coli 19 c2p10D_ 10.0 23 PDB header:hydrolase Chain: D: PDB Molecule:mll9387 protein; PDBTitle: crystal structure of a putative phosphonopyruvate hydrolase (mll9387)2 from mesorhizobium loti maff303099 at 2.15 a resolution 20 c3olhA_ 9.9 3 PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: human 3-mercaptopyruvate sulfurtransferase 21 d1mjsa_ not modelled 9.8 37 Fold:SMAD/FHA domain Superfamily:SMAD/FHA domain Family:SMAD domain 22 c2kvoA_ not modelled 8.7 33 PDB header:photosynthesis Chain: A: PDB Molecule:photosystem ii reaction center psb28 protein; PDBTitle: solution nmr structure of photosystem ii reaction center psb28 protein2 from synechocystis sp.(strain pcc 6803), northeast structural3 genomics consortium target sgr171 23 d1khua_ not modelled 8.4 42 Fold:SMAD/FHA domain Superfamily:SMAD/FHA domain Family:SMAD domain 24 d2hy5b1 not modelled 8.1 21 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 25 d1wija_ not modelled 6.9 36 Fold:LEM/SAP HeH motif Superfamily:DNA-binding domain of EIN3-like Family:DNA-binding domain of EIN3-like 26 c3pg6D_ not modelled 6.7 27 PDB header:ligase Chain: D: PDB Molecule:e3 ubiquitin-protein ligase dtx3l; PDBTitle: the carboxyl terminal domain of human deltex 3-like 27 c3eytA_ not modelled 6.6 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein spoa0173; PDBTitle: crystal structure of thioredoxin-like superfamily protein spoa0173 28 d1oi0a_ not modelled 6.4 14 Fold:Cytidine deaminase-like Superfamily:JAB1/MPN domain Family:JAB1/MPN domain 29 d1uara2 not modelled 6.3 9 Fold:Rhodanese/Cell cycle control phosphatase Superfamily:Rhodanese/Cell cycle control phosphatase Family:Multidomain sulfurtransferase (rhodanese) 30 c2oq2B_ not modelled 6.2 6 PDB header:oxidoreductase Chain: B: PDB Molecule:phosphoadenosine phosphosulfate reductase; PDBTitle: crystal structure of yeast paps reductase with pap, a product complex 31 d2ok5a4 not modelled 5.7 21 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 32 c3ddrC_ not modelled 5.6 23 PDB header:membrane protein/heme binding protein Chain: C: PDB Molecule:hemophore hasa; PDBTitle: structure of the serratia marcescens hemophore receptor hasr-ile671gly2 mutant in complex with its hemophore hasa and heme 33 c2z5bB_ not modelled 5.6 19 PDB header:chaperone Chain: B: PDB Molecule:uncharacterized protein ylr021w; PDBTitle: crystal structure of a novel chaperone complex for yeast2 20s proteasome assembly 34 d1hpla2 not modelled 5.5 5 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Pancreatic lipase, N-terminal domain 35 c3gztF_ not modelled 5.5 18 PDB header:virus Chain: F: PDB Molecule:outer capsid glycoprotein vp7; PDBTitle: vp7 recoated rotavirus dlp 36 d2cu2a2 not modelled 5.3 25 Fold:Nucleotide-diphospho-sugar transferases Superfamily:Nucleotide-diphospho-sugar transferases Family:mannose-1-phosphate guanylyl transferase 37 c1boiA_ not modelled 5.3 5 PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: n-terminally truncated rhodanese 38 d1gpla2 not modelled 5.1 8 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Pancreatic lipase, N-terminal domain 39 d1lpbb2 not modelled 5.0 5 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Pancreatic lipase, N-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0