Job Description P77730 Confidence 99.97% Date Thu Jan 5 12:32:10 GMT 2012 Rank 82 Aligned Residues 394 % Identity 13% Template c3e9kA_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:kynureninase; PDBTitle: crystal structure of homo sapiens kynureninase-3-hydroxyhippuric acid2 inhibitor complex Resolution 1.70 Å

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		25	.	.	.	.			30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.
Predicted Secondary structure							.	.
Query SS confidence							.	.
Query Sequence		R	L	P	S	L	.	.	R	D	Q	V	A	L	S	G	M	S	F	M	T	V	S	H	A	Y	Q	L	L	E	S	Q	G	Y	I	I	A	R	P	Q	S	G	Y	Y	V	A	P	Q	A	I	K	M	P	K	A	P	V	I	P	V	T	R	D	E	A	V	D	I	N	T	Y	I	F	D	M	L	Q	A	S	R	D
Query Conservation							.	.
Alig confidence							.	.																											.	.	.																										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																			.	.	.																										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		E	L	P	A	D	T	V	Q	R	I	A	A	E	L	K	C	H	P	T	D	E	R	V	A	L	H	L	D	E	E	D	K	L	.	.	.	R	H	F	R	E	F	Y	I	P	K	I	Q	D	L	P	P	V	D	L	S	L	V	N	K	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure																T	S		T	T	S										T		T	T	.	.	.	G	G	G	G			B			B	G	G	G	S	T	T			G	G	G	S		T	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																			.	.	.																										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		7	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.				40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.
		103	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.				.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																												.	.	.
Query SS confidence																																												.	.	.
Query Sequence		P	S	V	V	P	F	A	S	A	F	P	D	P	R	L	F	P	L	Q	Q	L	N	R	S	L	A	Q	V	S	K	T	A	T	A	M	S	V	I	E	N	L	P	.	.	.	P	G	N	A	E	L	R	Q	A	I	A	R	R	Y	A	L	Q	G	I	T	I	S	P	D	E	I	V	I	T	A	G	A	L	E	A
Query Conservation																																												.	.	.
Alig confidence																																												.	.	.																.	.	.	.	.
Template Conservation																																																														.	.	.	.	.
Template Sequence		E	N	A	I	Y	F	L	G	N	S	L	G	L	Q	P	K	M	V	K	T	Y	L	E	E	E	L	D	K	W	A	K	I	A	A	Y	G	H	E	V	G	K	R	P	W	I	T	G	D	E	S	I	V	G	L	M	K	D	I	V	G	.	.	.	.	.	A	N	E	K	E	I	A	L	M	N	A	L	T	V	N
Template Known Secondary structure			B					B	T	T	T	S			B		T	T																G	G	G	G	G	T	S	S	S	S		G	G	G	T	T					G	G	G					T	.	.	.	.	.			G	G	G					S
Template Predicted Secondary structure																																																														.	.	.	.	.
Template SS confidence
		66	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.						.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
		180	.	.	.	.	.	.	.	.	.	190				.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.										.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.		.	.	240	.	.	.	.	.	.
Predicted Secondary structure													.	.	.																						.	.	.	.	.	.	.	.	.																											.
Query SS confidence													.	.	.																						.	.	.	.	.	.	.	.	.																											.
Query Sequence		L	N	L	S	L	Q	A	V	T	E	P	.	.	.	G	D	W	V	I	V	E	N	P	C	F	Y	G	A	L	Q	A	L	E	R	L	.	.	.	.	.	.	.	.	.	R	L	K	A	L	S	V	A	T	D	V	K	E	G	I	D	L	Q	A	L	E	L	A	L	Q	E	.	Y	P	V	K	A	C	W	L	M
Query Conservation													.	.	.																						.	.	.	.	.	.	.	.	.																											.
Alig confidence													.	.	.																						.	.	.	.	.	.	.	.	.																											.
Template Conservation
Template Sequence		L	H	L	L	M	L	S	F	F	K	P	T	P	K	R	Y	K	I	L	L	E	A	K	A	F	P	S	D	H	Y	A	I	E	S	Q	L	Q	L	H	G	L	N	I	E	E	S	M	R	M	I	K	P	R	E	G	E	E	T	L	R	I	E	D	I	L	E	V	I	E	K	E	G	D	S	I	A	V	I	L	F
Template Known Secondary structure														S	S	S							T	T																T	T														T	T		S	S														G	G	G
Template Predicted Secondary structure
Template SS confidence
		141	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220
		247	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	N	S	Q	N	P	L	G	F	T	L	T	P	Q	K	K	A	Q	L	V	A	L	L	N	Q	Y	N	V	T	L	I	E	D	D	V	Y	S	E	L	Y	F	G	R	E	K	P	L	P	A	K	A	W	D	R	H	D	G	V	L	H	C	S	S	F	S	K	C	L	V	P	G	F	R	I	G	W	V	A	A	G
Query Conservation
Alig confidence														.	.	.																										.	.	.	.	.	.
Template Conservation														.	.	.																										.	.	.	.	.	.
Template Sequence		S	G	V	H	F	Y	T	G	Q	H	F	N	.	.	.	I	P	A	I	T	K	A	G	Q	A	K	G	C	Y	V	G	F	D	L	A	H	A	V	G	N	.	.	.	.	.	.	V	E	L	Y	L	H	D	W	G	V	D	F	A	C	W	C	S	Y	K	Y	L	N	A	G	A	G	G	I	A	G	A	F	I	H
Template Known Secondary structure			S	B		T	T	T		B	B			.	.	.											T	T								T	T	T	T	T	T	.	.	.	.	.	.	S								T								S	S	S	T	T				T	T
Template Predicted Secondary structure														.	.	.																										.	.	.	.	.	.
Template SS confidence
		221	.	.	.	.	.	.	.	.	230	.	.				.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.							.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.
		327	.	.	330	.	.	.	.	.	.	.	.	.	340																										.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.
Predicted Secondary structure																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		K	H	A	R	K	I	Q	R	L	Q	L	M	S	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L	S	T	S	S	P	M	Q	L	A	L	V	D	Y	L	S	T	R	R	Y	D	A	H	L	R	R	L	R	R	Q	L	A	E	R	K	Q	R	A	W	Q	A
Query Conservation																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		E	K	H	A	H	T	I	K	P	A	L	V	G	W	F	G	H	E	L	S	T	R	F	K	M	D	N	K	L	Q	L	I	P	G	V	C	G	F	R	I	S	N	P	P	I	L	L	V	C	S	L	H	A	S	L	E	I	F	K	Q	A	T	M	K	A	L	R	K	K	S	V	L	L	T	G	Y	L	E	Y	L
Template Known Secondary structure		G	G	G	T	T	T	S			S	S			G	G	G	B						T	T			S				B		S	S	G	G	G	G			S
Template Predicted Secondary structure
Template SS confidence
		292	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.
		382	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.					.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.			.	.	.	450	.	.	.	.	.
Predicted Secondary structure																		.	.	.	.																																																		.	.
Query SS confidence																		.	.	.	.																																																		.	.
Query Sequence		L	L	R	Y	L	P	A	E	V	K	I	H	H	N	D	S	.	.	.	.	G	Y	F	L	W	L	E	L	P	E	P	L	D	A	G	E	L	S	L	A	A	L	T	H	H	I	S	I	A	P	G	K	M	F	S	T	G	E	N	W	S	R	F	F	R	F	N	T	A	.	.	W	Q	W	G	E	R	E	E	Q
Query Conservation																		.	.	.	.																																																		.	.
Alig confidence								.										.	.	.	.											.	.																					.	.	.	.	.	.	.	.										.	.
Template Conservation								.																								.	.																					.	.	.	.	.	.	.	.
Template Sequence		I	K	H	N	Y	G	.	V	V	N	I	I	T	P	S	H	V	E	E	R	G	C	Q	L	T	I	T	F	S	V	.	.	P	N	K	D	V	F	Q	E	L	E	K	R	G	V	V	C	D	K	R	N	.	.	.	.	.	.	.	.	P	N	G	I	R	V	A	P	V	P	L	Y	N	S	F	H	D	V	Y	K
Template Known Secondary structure								.						S		S	S	G	G	G	B		S									.	.	T	T									T	T	T							T	.	.	.	.	.	.	.	.	T	T					B			T	T	T
Template Predicted Secondary structure								.																								.	.																					.	.	.	.	.	.	.	.
Template SS confidence
		372	.	.	.	.	.		.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400			.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420									.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440
		456	.	.	.	460	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	V	K	Q	L	G	K	L	I	Q
Query Conservation
Alig confidence
Template Conservation
Template Sequence		F	T	N	L	L	T	S	I	L	D
Template Known Secondary structure											T
Template Predicted Secondary structure
Template SS confidence
		450	.	.	.	.	.	.	.	.	.