Job Description P23886 Confidence 100.00% Date Thu Jan 5 11:40:21 GMT 2012 Rank 4 Aligned Residues 568 % Identity 21% Template c3g5uB_ PDB info PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Resolution 3.80 Å

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		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.																	.	.	60	.	.	.	.
Predicted Secondary structure																																																											.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																																											.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		M	R	A	L	L	P	Y	L	A	L	Y	K	R	H	K	W	M	L	S	L	G	I	V	L	A	I	V	T	L	L	A	S	I	G	L	L	T	L	S	G	W	F	L	S	A	S	A	V	A	G	V	A	G	L	Y	S	F	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	Y	M	L	P	A	A
Query Conservation																																																											.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence												.	.																																														.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation												.	.
Template Sequence		V	L	T	M	F	R	Y	A	G	W	.	.	L	D	R	L	Y	M	L	V	G	T	L	A	A	I	I	H	G	V	A	L	P	L	M	M	L	I	F	G	D	M	T	D	S	F	A	S	V	G	N	V	S	K	N	S	T	N	M	S	E	A	D	K	R	A	M	F	A	K	L	E	E	E	M	T	T	Y	A	Y
Template Known Secondary structure		T					T					.	.																																													S	S		S
Template Predicted Secondary structure												.	.
Template SS confidence
		35	.	.	.	.	40	.	.	.	.			.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.
		65	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	V	R	G	A	A	I	T	R	T	A	G	R	Y	F	E	R	L	V	S	H	D	A	T	F	R	V	L	Q	H	L	R	I	Y	T	F	S	K	L	L	P	L	S	P	A	G	L	A	R	Y	R	Q	G	E	L	L	N	R	V	V	A	D	V	D	T	L	D	H	L	Y	L	R	V	I	S	P	L	V	G	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	Y	T	G	I	G	A	G	V	L	I	V	A	Y	I	Q	V	S	F	W	C	L	A	A	G	R	Q	I	H	K	I	R	Q	K	F	F	H	A	I	M	N	Q	E	I	G	W	F	D	V	H	D	V	G	E	L	N	T	R	L	T	D	D	V	S	K	I	N	E	G	I	G	D	K	I	G	M	F	F	Q	A
Template Known Secondary structure																																												T	T					S	S		S
Template Predicted Secondary structure
Template SS confidence
		113	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.
		145	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	V	V	I	M	V	V	T	I	G	L	S	F	L	D	F	T	L	A	F	T	L	G	G	I	M	L	L	T	L	F	L	M	P	P	L	F	Y	R	A	G	K	S	T	G	Q	N	L	T	H	L	R	G	Q	Y	R	Q	Q	L	T	A	W	L	Q	G	Q	A	E	L	T	I	F	G	A	S	D	R	Y	R	T
Query Conservation
Alig confidence																														.
Template Conservation																														.
Template Sequence		M	A	T	F	F	G	G	F	I	I	G	F	T	R	G	W	K	L	T	L	V	I	L	A	I	S	P	V	.	L	G	L	S	A	G	I	W	A	K	I	L	S	S	F	T	D	K	E	L	H	A	Y	A	K	A	G	A	V	A	E	E	V	L	A	A	I	R	T	V	I	A	F	G	G	Q	K	K	E	L	E
Template Known Secondary structure															T	T	T	T	S											.																													T	T	T											T	T					S
Template Predicted Secondary structure																														.
Template SS confidence
		193	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220		.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
		225	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	L	E	N	T	E	I	Q	W	L	E	A	Q	R	R	Q	S	E	L	T	A	L	S	Q	A	I	M	L	L	I	G	A	L	A	V	I	L	M	L	W	M	A	S	G	G	V	G	G	N	A	Q	P	G	A	L	I	A	L	F	V	F	C	A	L	A	A	F	E	A	L	A	P	V	T	G	A	F	Q	H	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	Y	N	N	N	L	E	E	A	K	R	L	G	I	K	K	A	I	T	A	N	I	S	M	G	A	A	F	L	L	I	Y	A	S	Y	A	L	A	F	W	Y	G	T	S	L	V	I	S	K	E	Y	S	I	G	Q	V	L	T	V	F	F	S	V	L	I	G	A	F	S	V	G	Q	A	S	P	N	I	E	A	F
Template Known Secondary structure																T	T	T																																S	S	S		S	S
Template Predicted Secondary structure
Template SS confidence
		272	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.
		305	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.			.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.		.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.
Predicted Secondary structure																							.	.																								.
Query SS confidence																							.	.																								.
Query Sequence		G	Q	V	I	A	S	A	V	R	I	S	D	L	T	D	Q	K	P	E	V	T	.	.	F	P	D	T	Q	T	R	V	A	D	R	V	S	L	T	L	R	D	V	Q	F	T	Y	.	P	E	Q	S	Q	Q	A	L	K	G	I	S	L	Q	V	N	A	G	E	H	I	A	I	L	G	R	T	G	C	G	K	S	T
Query Conservation																							.	.																								.
Alig confidence																							.	.																								.
Template Conservation
Template Sequence		A	N	A	R	G	A	A	Y	E	V	F	K	I	I	D	N	K	P	S	I	D	S	F	S	K	S	G	H	K	P	D	N	I	Q	G	N	L	E	F	K	N	I	H	F	S	Y	P	S	R	K	E	V	Q	I	L	K	G	L	N	L	K	V	K	S	G	Q	T	V	A	L	V	G	N	S	G	C	G	K	S	T
Template Known Secondary structure														T	T	S						S	S			S						T	T		S													S	S	T	T	S			S										T	T									S	S	T	T
Template Predicted Secondary structure
Template SS confidence
		352	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.
		382	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460
Predicted Secondary structure																																																																																	.
Query SS confidence																																																																																	.
Query Sequence		L	L	Q	Q	L	T	R	A	W	D	P	Q	Q	G	E	I	L	L	N	D	S	P	I	A	S	L	N	E	A	A	L	R	Q	T	I	S	V	V	P	Q	R	V	H	L	F	S	A	T	L	R	D	N	L	L	L	A	S	P	G	S	S	D	E	A	L	S	E	I	L	R	R	V	G	L	E	K	L	L	E	.
Query Conservation																																																																																	.
Alig confidence																																																																																	.
Template Conservation
Template Sequence		T	V	Q	L	M	Q	R	L	Y	D	P	L	D	G	M	V	S	I	D	G	Q	D	I	R	T	I	N	V	R	Y	L	R	E	I	I	G	V	V	S	Q	E	P	V	L	F	A	T	T	I	A	E	N	I	R	Y	G	R	E	D	V	T	M	D	E	I	E	K	A	V	K	E	A	N	A	Y	D	F	I	M	K
Template Known Secondary structure						T	T	T	S	S			S							T	T			G	G	G	S														S	S					S	S											S	S													T	T		T	T
Template Predicted Secondary structure
Template SS confidence
		432	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.
			461	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.
Predicted Secondary structure		.
Query SS confidence		.
Query Sequence		.	D	A	G	L	N	S	W	L	G	E	G	G	R	Q	L	S	G	G	E	L	R	R	L	A	I	A	R	A	L	L	H	D	A	P	L	V	L	L	D	E	P	T	E	G	L	D	A	T	T	E	S	Q	I	L	E	L	L	A	E	M	M	R	E	K	T	V	L	M	V	T	H	R	L	R	G	L	S	R	F
Query Conservation		.
Alig confidence		.
Template Conservation
Template Sequence		L	P	H	Q	F	D	T	L	V	G	E	R	G	A	Q	L	S	G	G	Q	K	Q	R	I	A	I	A	R	A	L	V	R	N	P	K	I	L	L	L	D	E	A	T	S	A	L	D	T	E	S	E	A	V	V	Q	A	A	L	D	K	A	R	E	G	R	T	T	I	V	I	A	H	R	L	S	T	V	R	N	A
Template Known Secondary structure		S	T	T	G	G	G				S	S	S	S		S	S																			S						B	T	T		S	S																T	T	S	S							S						T	T
Template Predicted Secondary structure
Template SS confidence
		512	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.
		540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	Q	I	I	V	M	D	N	G	Q	I	I	E	Q	G	T	H	A	E	L	L	A	R	Q	G	R	Y	Y	Q	F	K	Q
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	V	I	A	G	F	D	G	G	V	I	V	E	Q	G	N	H	D	E	L	M	R	E	K	G	I	Y	F	K	L	V	M
Template Known Secondary structure		S						S	S	S															T	S
Template Predicted Secondary structure
Template SS confidence
		592	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.