Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	M	F	F	R	L	T	A	L	A	G	L	L	A	I	A	G	Q	T	F	A	V	E	D	I	T	R	A	D	Q	I	P	V	L	K	E	E	T	Q	H	A	T	V	S	E	R	V	T	S	R	F	T	R	S	H	Y	R	Q	F
Secondary structure
SS confidence
Disorder		?	?	?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	L	D	Q	A	F	S	A	K	I	F	D	R	Y	L	N	L	L	D	Y	S	H	N	V	L	L	A	S	D	V	E	Q	F	A	K	K	K	T	E	L	G	D	E	L	R	S	G	K	L	D	V	F	Y	D	L	Y	N	L	A	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	R	R	F	E	R	Y	Q	Y	A	L	S	V	L	E	K	P	M	D	F	T	G	N	D	T	Y	N	L	D	R	S	K	A	P	W	P	K	N	E	A	E	L	N	A	L	W	D	S	K	V	K	F	D	E	L	S	L	K	L	T
Secondary structure
SS confidence
Disorder																?																?			?	?	?	?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	K	T	D	K	E	I	R	E	T	L	T	R	R	Y	K	F	A	I	R	R	L	A	Q	T	N	S	E	D	V	F	S	L	A	M	T	A	F	A	R	E	I	D	P	H	T	N	Y	L	S	P	R	N	T	E	Q	F	N	T	E
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		M	S	L	S	L	E	G	I	G	A	V	L	Q	M	D	D	D	Y	T	V	I	N	S	M	V	A	G	G	P	A	A	K	S	K	A	I	S	V	G	D	K	I	V	G	V	G	Q	T	G	K	P	M	V	D	V	I	G	W	R	L
Secondary structure
SS confidence
Disorder		?	?	?																														?	?			?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	D	V	V	A	L	I	K	G	P	K	G	S	K	V	R	L	E	I	L	P	A	G	K	G	T	K	T	R	T	V	T	L	T	R	E	R	I	R	L	E	D	R	A	V	K	M	S	V	K	T	V	G	K	E	K	V	G	V	L
Secondary structure
SS confidence
Disorder											?	?														?															?	?		?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	I	P	G	F	Y	V	G	L	T	D	D	V	K	V	Q	L	Q	K	L	E	K	Q	N	V	S	S	V	I	I	D	L	R	S	N	G	G	G	A	L	T	E	A	V	S	L	S	G	L	F	I	P	A	G	P	I	V	Q	V	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		D	N	N	G	K	V	R	E	D	S	D	T	D	G	Q	V	F	Y	K	G	P	L	V	V	L	V	D	R	F	S	A	S	A	S	E	I	F	A	A	A	M	Q	D	Y	G	R	A	L	V	V	G	E	P	T	F	G	K	G	T	V
Secondary structure
SS confidence
Disorder					?					?					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Q	Q	Y	R	S	L	N	R	I	Y	D	Q	M	L	R	P	E	W	P	A	L	G	S	V	Q	Y	T	I	Q	K	F	Y	R	V	N	G	G	S	T	Q	R	K	G	V	T	P	D	I	I	M	P	T	G	N	E	E	T	E	T	G
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?	?																																		?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		E	K	F	E	D	N	A	L	P	W	D	S	I	D	A	A	T	Y	V	K	S	G	D	L	T	A	F	E	P	E	L	L	K	E	H	N	A	R	I	A	K	D	P	E	F	Q	N	I	M	K	D	I	A	R	F	N	A	M	K	D
Secondary structure
SS confidence
Disorder		?	?	?	?										?	?	?	?	?	?	?		?	?	?	?										?					?	?	?																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		K	R	N	I	V	S	L	N	Y	A	V	R	E	K	E	N	N	E	D	D	A	T	R	L	A	R	L	N	E	R	F	K	R	E	G	K	P	E	L	K	K	L	D	D	L	P	K	D	Y	Q	E	P	D	P	Y	L	D	E	T	V
Secondary structure
SS confidence
Disorder		?		?														?																?	?	?	?	?	?	?		?						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.
Sequence		N	I	A	L	D	L	A	K	L	E	K	A	R	P	A	E	Q	P	A	P	V	K
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1fc9 chain A Region: 159 - 538 Aligned: 354 Modelled: 380 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:photosystem ii d1 protease; PDBTitle: photosystem ii d1 c-terminal processing protease Phyre2 PDB 3k50 chain A Region: 165 - 540 Aligned: 345 Modelled: 354 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative s41 protease; PDBTitle: crystal structure of putative s41 protease (yp_211611.1) from2 bacteroides fragilis nctc 9343 at 2.00 a resolution Phyre2 PDB 1k32 chain E Region: 140 - 542 Aligned: 360 Modelled: 396 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: E: PDB Molecule:tricorn protease; PDBTitle: crystal structure of the tricorn protease Phyre2 PDB 1n6d chain E Region: 140 - 542 Aligned: 360 Modelled: 396 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: E: PDB Molecule:tricorn protease; PDBTitle: tricorn protease in complex with tetrapeptide chloromethyl2 ketone derivative Phyre2 PDB 1fc6 chain A domain 4 Region: 159 - 531 Aligned: 266 Modelled: 286 Confidence: 100.0% Identity: 28% Fold: ClpP/crotonase Superfamily: ClpP/crotonase Family: Tail specific protease, catalytic domain Phyre2 PDB 3dja chain A Region: 175 - 531 Aligned: 318 Modelled: 345 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:protein ct_858; PDBTitle: crystal structure of cpaf solved with mad Phyre2 PDB 1j7x chain A Region: 350 - 532 Aligned: 172 Modelled: 183 Confidence: 100.0% Identity: 24% Fold: ClpP/crotonase Superfamily: ClpP/crotonase Family: Tail specific protease, catalytic domain Phyre2 PDB 1k32 chain A domain 4 Region: 159 - 542 Aligned: 266 Modelled: 295 Confidence: 100.0% Identity: 18% Fold: ClpP/crotonase Superfamily: ClpP/crotonase Family: Tail specific protease, catalytic domain Phyre2 PDB 3shw chain A Region: 246 - 541 Aligned: 259 Modelled: 278 Confidence: 99.7% Identity: 12% PDB header:cell adhesion Chain: A: PDB Molecule:tight junction protein zo-1; PDBTitle: crystal structure of zo-1 pdz3-sh3-guk supramodule complex with2 connexin-45 peptide Phyre2 PDB 1fc6 chain A domain 3 Region: 242 - 336 Aligned: 89 Modelled: 95 Confidence: 99.6% Identity: 35% Fold: PDZ domain-like Superfamily: PDZ domain-like Family: Tail specific protease PDZ domain Phyre2 PDB 1wif chain A Region: 247 - 325 Aligned: 74 Modelled: 79 Confidence: 99.3% Identity: 24% Fold: PDZ domain-like Superfamily: PDZ domain-like Family: PDZ domain Phyre2 PDB 2edz chain A Region: 215 - 321 Aligned: 91 Modelled: 107 Confidence: 99.1% Identity: 25% PDB header:signaling protein Chain: A: PDB Molecule:pdz domain-containing protein 1; PDBTitle: solution structures of the pdz domain of mus musculus pdz2 domain-containing protein 1 Phyre2 PDB 2krg chain A Region: 222 - 321 Aligned: 87 Modelled: 94 Confidence: 99.1% Identity: 31% PDB header:signaling protein Chain: A: PDB Molecule:na(+)/h(+) exchange regulatory cofactor nhe-rf1; PDBTitle: solution structure of human sodium/ hydrogen exchange2 regulatory factor 1(150-358) Phyre2 PDB 1w9e chain A domain 1 Region: 241 - 321 Aligned: 75 Modelled: 81 Confidence: 99.1% Identity: 21% Fold: PDZ domain-like Superfamily: PDZ domain-like Family: PDZ domain Phyre2 PDB 3k1r chain A Region: 247 - 323 Aligned: 69 Modelled: 77 Confidence: 99.1% Identity: 25% PDB header:structural protein Chain: A: PDB Molecule:harmonin; PDBTitle: structure of harmonin npdz1 in complex with the sam-pbm of2 sans Phyre2 PDB 2z9i chain A domain 1 Region: 244 - 334 Aligned: 82 Modelled: 91 Confidence: 99.1% Identity: 27% Fold: PDZ domain-like Superfamily: PDZ domain-like Family: HtrA-like serine proteases Phyre2 PDB 2qkt chain B Region: 247 - 322 Aligned: 70 Modelled: 76 Confidence: 99.1% Identity: 20% PDB header:peptide binding protein Chain: B: PDB Molecule:inactivation-no-after-potential d protein; PDBTitle: crystal structure of the 5th pdz domain of inad Phyre2 PDB 1qau chain A Region: 241 - 332 Aligned: 87 Modelled: 92 Confidence: 99.0% Identity: 22% Fold: PDZ domain-like Superfamily: PDZ domain-like Family: PDZ domain Phyre2 PDB 2kom chain A Region: 227 - 324 Aligned: 93 Modelled: 98 Confidence: 99.0% Identity: 19% PDB header:signaling protein Chain: A: PDB Molecule:partitioning defective 3 homolog; PDBTitle: solution structure of humar par-3b pdz2 (residues 451-549) Phyre2 PDB 1ueq chain A Region: 247 - 321 Aligned: 70 Modelled: 75 Confidence: 99.0% Identity: 33% Fold: PDZ domain-like Superfamily: PDZ domain-like Family: PDZ domain Phyre2 1 c1fc9A_ 2 c3k50A_ 3 c1k32E_ 4 c1n6dE_ 5 d1fc6a4 6 c3djaA_ 7 d1j7xa_ 8 d1k32a4 9 c3shwA_ 10 d1fc6a3 11 d1wifa_ 12 c2edzA_ 13 c2krgA_ 14 d1w9ea1 15 c3k1rA_ 16 d2z9ia1 17 c2qktB_ 18 d1qaua_ 19 c2komA_ 20 d1ueqa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294