|   |
25 | . | . | . | . | 30 | . | |
|
|
. | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | |
|
. | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
80 | . | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |  | . | . | . |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
| . | . |
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  | . | . | . | . | . | . | . | . | . | . |  |  |  |
|
|  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
S | P | V | K | V | G | S | . |
. |
. |
K | I | D | T | E | G | A | L | L | G | N | I | I | L | Q | V | L | E | S | H | G | V | P | T | V | N | K | V | Q | . |
. |
L | G | T | T | P | V | V | R | G | A | I | T | S | G | E | L | D | I | Y | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
P | E | Y | T | G | N | G | A | F | F |
Query Conservation |   |
  |   |
|   |
|
|   | . | . | . |   |   |
|
|
|   |   |
|
|
|   |
|   |   |   |   |
|
|   |   |
|
|   |
|
|   |   |   |   | . | . |   |   |   |   |   |   |   |   |   |
|
|   |   |
|
|
|
|
|   | . | . | . | . | . | . | . | . | . | . |   |
|
|
|
|   |   |
|   |   |
Alig confidence |   |
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |
|   |
|   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|   |   |   |
|   |
|   |
|   |
|   |   |   |
|   |
|
|   |   |   |   |   |   |   |   |
|   |   |
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|
|
Template Sequence |   |
D | N | W | R | Y | A | H | E | E | Y | E | G | D | V | Q | D | V | F | A | Q | A | F | K | G | Y | V | E | D | N | S | D | H | T | V | Q | V | Y | R | F | G | E | L | G | E | S | D | D | I | M | E | Q | T | Q | N | G | I | L | Q | F | V | N | Q | S | P | G | F | T | G | S | L | I | P | S | A | Q | I | F | F | I | P |
Template Known Secondary structure |   |
|  |  |  |  |  |
| S | S |
| T | T | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
|  |  |  |  |  |
| T | T | S | S |
| S |  |  |  |  |  |  |  |  |  | T | T | S |
| S |  |  |  |  |
|  |  |  |  | T | T | T | S | G | G | G | G | G | G | G | S | T |
Template Predicted Secondary structure |   |
|
|  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 |
  |
  |   |
90 | . | . | . | . | . | |
|
|
|
. | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
F | K | D | E | N | D | . |
. |
. |
. |
A | A | W | K | N | A | Q | Q | G | Y | E | K | V | K | K | L | D | S | E | H | N | K | L | I | W | L | T | P | A | P | A | N | N | T | W | T | I | A | V | R | Q | D | V | A | E | K | N | K | L | T | S | L | A | D | L | S | R | Y | L | Q | E | G | G | T | F | K | L | A | A | S |
Query Conservation |   |
  |   |   |   |   |   | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |   |   |
|
|   |
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
Alig confidence |   |
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
Template Conservation |   |
  |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|   |   |   |   |   |
|   |   |   |   |   |   |   |   |
| . | . | . | . | . | . | . |
|   |
|   |   |
|
|
|
|   |
|
|
|   |   |   | . | . | . | . | . | . |
Template Sequence |   |
Y | L | M | P | T | D | M | D | T | V | L | E | F | F | D | E | S | K | A | I | N | E | M | F | P | K | L | Y | A | E | H | G | L | E | L | L | K | M | Y | P | E | G | E | M | V | V | T | A | D | E | P | . |
. |
. |
. |
. |
. |
. |
I | T | S | P | E | D | F | D | N | K | K | I | R | T | M | T | . |
. |
. |
. |
. |
. |
Template Known Secondary structure |   |
T |
| S |
| S | S |  |  |  |  |  |  |  |  |  |  |
|  |  |  |  | T |  |  |  |  |  |  |  | T | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
| . | . | . | . | . | . | . |
|
| S | G | G | G | G | T | T |
|  |  |  |  |
| S | . | . | . | . | . | . |
Template Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
| . | . | . | . | . | . | . |
|
|
|  |  |  |  |
|
|
|  |  |  |  |  |
| . | . | . | . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
81 | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | |
|
|
|
|
|
|
. | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | |
|
|
|
|
|
  |
  |   |
166 | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | |
|
230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
| . | . |  |  |  |  |  |
|
|
|
|
|
|
|
|  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | E | F | I | E | R | A | D | A | L | P | A | F | E | K | A | Y | G | F | K | L | G | Q | D | Q | L | L | S | L | A | G | G | D | T | A | V | T | I | K | A | A | A | Q | Q | T | S | G | V | N | A | A | M | A | Y | G | T | D | G | P | V | A | A | L | G | . |
. |
L | Q | T | L | S | D | P | Q | G | V | Q | P | I | Y |
Query Conservation |   |
  |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |   |
|   |
|   |   |   |   |   |   |   |   | . | . |
|   |   |
|
|
|
|   |   |   |   |
|   |   |
Alig confidence |   |
. | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
. | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |
|
|
| . | . | . | . | . |   |
|
|   |
|   |   |   | . | . | . | . | . |
|
|
|   |
|
|
|   |
|   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
N | P | L | L | A | E | T | Y | K | A | F | G | A | . |
. |
. |
. |
. |
T | P | T | P | L | P | W | G | . |
. |
. |
. |
. |
E | V | Y | G | G | L | Q | T | G | I | I | D | G | Q | E | N | P | I | F | W | I | E | S | G | G | L | Y | E | V | S | P | N | L | T | F | T | S | H | G | W | F | T | T |
Template Known Secondary structure |   |
. | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  | T |
| . | . | . | . | . |  |  |  |  |
|
| G | G | . | . | . | . | . | G |  |  |  |  |  |  |  | T | S |
| S |  |  |  |  |  |  |  |  |  |  |  | T | T | G | G | G | T |
|
|  |  |  |  |
|
|
|
|  |  |  |  |
Template Predicted Secondary structure |   |
. | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |
|
|
| . | . | . | . | . |  |  |  |  |  |
|  |  | . | . | . | . | . |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
148 | . | 150 | . | . | . | . | . | . | . | . | . | 160 | |
|
|
|
|
. | . | . | . | . | . | . | . | |
|
|
|
|
. | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . |
  |
  |   |
244 | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |
|  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | P | A | P | V | V | R | E | S | V | L | R | E | Y | P | Q | M | A | Q | W | L | Q | P | V | F | A | S | L | D | A | K | T | L | Q | Q | L | N | A | S | I | A | V | E | G | L | D | A | K | K | V | A | A | D | Y | L | K | Q | K | G |
Query Conservation |   |
  |   |   |   |
|
|   |   |   |   |   |   |   |   |
|   |   |   |   |   |
|   |   |   |
|   |   |
|
|   |
|   |
|   |   |
|   |   |   |
|   |   |   |
|   |   |   |
|
|
|
|   |   |
|
|   |   |
|
|
Alig confidence |   |
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   | . | . |   |   |
|   |   |   |
|   |   |
|   |   |   |   |
|   |   |
|   | . | . | . | . | . | . | . |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
Template Sequence |   |
A | M | . |
. |
M | A | N | Q | D | F | Y | E | G | L | S | E | E | D | Q | Q | L | V | Q | . |
. |
. |
. |
. |
. |
. |
D | A | A | D | A | A | Y | D | H | T | I | E | H | I | K | G | L | S | E | E | S | L | E | K | I | K | A | A | S |
Template Known Secondary structure |   |
 |  | . | . |  |  |  |  |  |  |  |  |  | S |
|  |  |  |  |  |  |  |  | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |  |  |
|
Template Predicted Secondary structure |   |
 |  | . | . |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
212 | . | |
|
. | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | |
|
|
|
|
|
|
. | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . |
  |