|   |
13 | . | . | . | . | |
. | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | |
|
|
|
|
. | . | . | . | . | . |
Predicted Secondary structure |   |
 |
|
|
|
| . |
|  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|  |  |  |
|
|  |  |  |  |  |
|
|
|  |  |  |  |  |  | . | . | . | . | . |  |  |  |  |  |
|
Query SS confidence |   |
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
Query Sequence |   |
L | T | T | R | Q | . |
S | V | M | V | V | G | A | A | V | I | D | V | I | A | D | A | Y | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
A | L | P | W | R | G | C | D | I | E | L | K | Q | Q | S | V | N | V | G | G | C | A | L | N | I | A | . |
. |
. |
. |
. |
V | A | L | K | R | L |
Query Conservation |   |
  |   |   |   |   | . |   |
|   |
|
|
|   |   |   |
|
|   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |
|
|
| . | . | . | . | . |   |   |
|   |   |
|
Alig confidence |   |
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |
|   |   |
|
|   |   |
|   |   |   |   |
|   |   |   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |
|
|
|   |   |   |   |   |
|   |   |
|   |
|
Template Sequence |   |
M | A | S | A | P | L | R | V | Y | V | Q | C | N | P | L | L | D | V | S | A | H | V | S | D | E | F | L | V | K | Y | G | L | E | R | G | T | A | I | L | L | S | E | R | Q | K | G | I | F | D | D | I | E | K | M | P | N | V | R | Y | V | P | G | G | S | G | L | N | V | A | R | V | A | Q | W | M | Q | Q | A | Y | K |
Template Known Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  | T | T |
|
| T | T |
|  |  |  |
|
| G | G | G | T | T |  |  |  |  |  | T | T | S | T | T |
|  |  |  |  |  | S |  |  |  |  |  |  |  |  |  |  |  |  |
| G | G | G | T |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 |
  |
  |   |
67 | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | |
|
|
|
. | 140 | . | . |
Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  | . | . | . | . |  |
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
Query Sequence |   |
G | I | E | A | G | N | A | L | P | L | G | Q | G | V | W | A | E | M | I | R | N | R | M | A | K | E | G | L | I | S | L | I | D | N | A | E | G | D | N | G | W | C | L | A | L | V | E | P | D | G | E | R | T | F | M | S | F | S | G | V | E | N | Q | W | N | R | Q | W | L | A | R | L | . |
. |
. |
. |
T | V | A | P |
Query Conservation |   |
|   |   |   |   |   |
|   |   |
|
|   |
|   |   |
|   |   |
|   |   |   |
|   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
Template Conservation |   |
|   |   |
|   |   |
|   |   |
|
|   |
|   |   |
|   |   |
|   |   |   |
|   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
G | K | F | V | T | Y | V | G | C | I | A | D | D | R | Y | G | K | V | L | K | E | A | A | E | H | E | G | I | V | M | A | V | E | H | T | T | K | A | G | S | G | A | C | A | V | C | I | T | G | K | E | R | T | L | V | A | D | L | G | A | A | N | H | L | S | S | E | H | M | R | S | P | A | V | V | R | A | M | D | E |
Template Known Secondary structure |   |
T | S | S |  |  |  |  |
|  |  |  | S | S |  |  |  |  |  |  |  |  |  |  |  | T | T | T |
|  |  |
|
|  |  |  | S | S | S |
|
|
|  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |
| G | G | G | G | G |
|
|  |  |  |  |  | S |  |  |  |  |  |  |  |  | T |
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
81 | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 |
  |
  |   |
143 | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | |
|
|
. | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | |
. | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
| . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|  |  |  |  |  |  |  |
|
| . |
|
|
|
|  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
Query Sequence |   |
G | S | L | L | Y | F | S | G | Y | Q | L | A | S | P | C | G | E | L | L | V | E | W | L | E | E | L | Q | D | V | T | P | F | I | D | F | G | P | R | I | G | . |
. |
. |
D | I | P | D | A | L | L | A | R | I | M | A | C | R | P | L | V | S | L | N | R | Q | E | A | E | I | A | A | E | . |
R | F | A | L | S | A | E |
Query Conservation |   |
  |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|
|   |   |   |
|   |   |
|   |   |   |   |   |   | . |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |
|   |   |   |
|   |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |
|   |
|   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
S | R | I | F | Y | F | S | G | F | T | L | T | V | . |
D | V | N | H | V | L | Q | A | C | R | K | A | R | E | V | D | G | L | F | M | I | N | L | S | A | P | F | I | M | Q | F | F | S | A | Q | L | G | E | V | L | P | Y | T | D | I | I | V | A | N | R | H | E | A | K | E | F | A | N | M | M | K | W | D | T | D | C |
Template Known Secondary structure |   |
| S |  |  |  |  |  | T | T |  |  |  |  | . |
|  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |
|  |  |  |  |  |
|
|
|  |  |  |  |  |  | S |  |  |  |  |  |  |  | G | G | G |
| S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|
|
|
|
|
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |
|
|
|
|
|
| . |
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
161 | . | . | . | . | . | . | . | . | 170 | . | . | . | |
. | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . |
  |
  |   |
219 | 220 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | |
|
|
260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . |
|
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
I | T | T | L | G | K | Q | W | Q | E | K | . |
. |
. |
. |
. |
. |
F | A | A | P | L | I | V | R | L | D | K | E | G | A | W | Y | F | S | N | D | A | S | G | C | I | P | A | F | P | T | . |
. |
. |
Q | V | V | D | T | I | G | A | G | D | S | H | A | G | G | V | L | A | G | L | A | S | G | L | P | L | A | D | A | V |
Query Conservation |   |
  |   |   |   |   |   |   |
|   |   |   | . | . | . | . | . | . |   |   |   |   |
|
|
|
|   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| . | . | . |   |
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |   |   |   |
|   |   |
|   |   |   |   |   |
|   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |
|   |   |
|   |   |
|   |   |
|   |   |
|   |
Template Sequence |   |
V | E | E | I | A | R | R | A | V | S | E | V | P | Y | T | G | T | K | G | R | V | V | V | F | T | R | D | I | E | S | T | V | L | A | T | K | D | G | V | E | T | V | P | V | P | Q | L | D | Q | D | K | V | I | D | M | N | G | A | G | D | A | F | M | G | G | F | L | S | A | Y | A | V | G | K | D | L | R | R | C | C |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  | S | S |
|
|
|
| S | S |
|
|  |  |  |  |  |  | T | T |  |  |  |  |  |  |  | T | T |  |  |  |  |  |
|
|
|
|
|
| T | T | S |
|
|
|
| T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |
|
|  |  |  |  |  |
Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . |
  |
  |   |
290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
L | L | G | N | A | V | A | S | W | V | V | G | H | R | G | G | D |
Query Conservation |   |
  |   |
|   |   |   |
|
|   |   |
|   |   |   |
|   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |
|   |   |   |
|
|   |   |
|   |   |   |
|   |   |
Template Sequence |   |
E | T | G | H | Y | T | A | Q | E | V | I | Q | R | K | P | S | F |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  | T |
|
|
|
|
|
Template Predicted Secondary structure |   |
 |  |  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . |
  |