Job Description P33941 Confidence 100.00% Date Wed Jan 25 15:20:50 GMT 2012 Rank 4 Aligned Residues 543 % Identity 15% Template c3g5uB_ PDB info PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Resolution 3.80 Å

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		2	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.																										.	.	.	.	.	.	50	.	.	.	.	.	.
Predicted Secondary structure																																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		E	L	L	V	L	V	W	R	Q	Y	R	W	P	F	I	S	V	M	A	L	S	L	A	S	A	A	L	G	I	G	L	I	A	F	I	N	Q	R	L	I	E	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	A	D	T	S	L	L	V	L	P	E	F	L	G
Query Conservation																																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		T	M	F	R	Y	A	G	W	L	D	R	L	Y	M	L	V	G	T	L	A	A	I	I	H	G	V	A	L	P	L	M	M	L	I	F	G	D	M	T	D	S	F	A	S	V	G	N	V	S	K	N	S	T	N	M	S	E	A	D	K	R	A	M	F	A	K	L	E	E	E	M	T	T	Y	A	Y	Y	Y	T	G
Template Known Secondary structure					T																																																	S	S		S
Template Predicted Secondary structure
Template SS confidence
		37	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.
		57	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.		.	.	.	.	.	130	.	.	.	.	.
Predicted Secondary structure																																																																						.
Query SS confidence																																																																						.
Query Sequence		L	L	L	L	L	M	A	V	T	L	G	S	Q	L	A	L	T	T	L	G	H	H	F	V	Y	R	L	R	S	E	F	I	K	R	I	L	D	T	H	V	E	R	I	E	Q	L	G	S	A	S	L	L	A	G	L	T	S	D	V	R	N	I	T	I	A	F	V	R	.	L	P	E	L	V	Q	G	I	I	L	T
Query Conservation																																																																						.
Alig confidence																																																																						.
Template Conservation
Template Sequence		I	G	A	G	V	L	I	V	A	Y	I	Q	V	S	F	W	C	L	A	A	G	R	Q	I	H	K	I	R	Q	K	F	F	H	A	I	M	N	Q	E	I	G	W	F	D	V	H	D	V	G	E	L	N	T	R	L	T	D	D	V	S	K	I	N	E	G	I	G	D	K	I	G	M	F	F	Q	A	M	A	T	F
Template Known Secondary structure																																								T	T					S	S		S
Template Predicted Secondary structure
Template SS confidence
		117	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.
		136	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.		.	.	.
Predicted Secondary structure																																																																														.
Query SS confidence																																																																														.
Query Sequence		I	G	S	A	A	Y	L	W	M	L	S	G	K	M	L	L	V	T	A	I	W	M	A	I	T	I	W	G	G	F	V	L	V	A	R	V	Y	K	H	M	A	T	L	R	E	T	E	D	K	L	Y	T	D	F	Q	T	V	L	E	G	R	K	E	L	T	L	N	R	E	R	A	E	Y	V	F	N	.	N	L	Y
Query Conservation																																																																														.
Alig confidence																																																																														.
Template Conservation
Template Sequence		F	G	G	F	I	I	G	F	T	R	G	W	K	L	T	L	V	I	L	A	I	S	P	V	L	G	L	S	A	G	I	W	A	K	I	L	S	S	F	T	D	K	E	L	H	A	Y	A	K	A	G	A	V	A	E	E	V	L	A	A	I	R	T	V	I	A	F	G	G	Q	K	K	E	L	E	R	Y	N	N	N
Template Known Secondary structure											T	T	T	T	S																																							T	T	T											T	T					S
Template Predicted Secondary structure
Template SS confidence
		197	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.
		215	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	P	D	A	Q	E	Y	R	H	H	I	I	R	A	D	T	F	H	L	S	A	V	N	W	S	N	I	M	M	L	G	A	I	G	L	V	F	W	M	A	N	S	L	G	W	A	D	T	N	V	A	A	T	Y	S	L	T	L	L	F	L	R	T	P	L	L	S	A	V	G	A	L	P	T	L	L	T	A	Q	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	E	E	A	K	R	L	G	I	K	K	A	I	T	A	N	I	S	M	G	A	A	F	L	L	I	Y	A	S	Y	A	L	A	F	W	Y	G	T	S	L	V	I	S	K	E	Y	S	I	G	Q	V	L	T	V	F	F	S	V	L	I	G	A	F	S	V	G	Q	A	S	P	N	I	E	A	F	A	N	A	R	G
Template Known Secondary structure											T	T	T																																S	S	S		S	S
Template Predicted Secondary structure
Template SS confidence
		277	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.
		295	.	.	.	.	300	.	.	.	.	.	.				.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.			.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.
Predicted Secondary structure														.	.	.																												.	.
Query SS confidence														.	.	.																												.	.
Query Sequence		A	F	N	K	L	N	K	F	A	L	A	P	.	.	.	F	K	A	E	F	P	R	P	Q	A	F	P	N	W	Q	T	L	E	L	R	N	V	T	F	A	Y	Q	.	.	D	N	A	F	S	V	G	P	I	N	L	T	I	K	R	G	E	L	L	F	L	I	G	G	N	G	S	G	K	S	T	L	A	M	L	L
Query Conservation														.	.	.																												.	.
Alig confidence														.	.	.																												.	.
Template Conservation
Template Sequence		A	A	Y	E	V	F	K	I	I	D	N	K	P	S	I	D	S	F	S	K	S	G	H	K	P	D	N	I	Q	G	N	L	E	F	K	N	I	H	F	S	Y	P	S	R	K	E	V	Q	I	L	K	G	L	N	L	K	V	K	S	G	Q	T	V	A	L	V	G	N	S	G	C	G	K	S	T	T	V	Q	L	M
Template Known Secondary structure									T	T	S						S	S			S						T	T		S													S	S	T	T	S			S										T	T									S	S	T	T								T
Template Predicted Secondary structure
Template SS confidence
		357	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.
		370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.						440	.	.	.	.
Predicted Secondary structure																																																																								.	.	.	.	.
Query SS confidence																																																																								.	.	.	.	.
Query Sequence		T	G	L	Y	Q	P	Q	S	G	E	I	L	L	D	G	K	P	V	S	G	E	Q	P	E	D	Y	R	K	L	F	S	A	V	F	T	D	V	W	L	F	D	Q	L	L	G	P	E	G	K	P	A	N	P	Q	L	V	E	K	W	L	A	Q	L	K	M	A	H	K	L	E	.	.	.	.	.	L	S	N	G	R
Query Conservation																																																																								.	.	.	.	.
Alig confidence																																																																								.	.	.	.	.
Template Conservation
Template Sequence		Q	R	L	Y	D	P	L	D	G	M	V	S	I	D	G	Q	D	I	R	T	I	N	V	R	Y	L	R	E	I	I	G	V	V	S	Q	E	P	V	L	F	A	T	T	I	A	E	N	I	R	Y	G	R	E	D	V	T	M	D	E	I	E	K	A	V	K	E	A	N	A	Y	D	F	I	M	K	L	P	H	Q	F
Template Known Secondary structure		T	T	S	S			S							T	T			G	G	G	S														S	S					S	S											S	S													T	T		T	T					S	T	T	G	G
Template Predicted Secondary structure
Template SS confidence
		437	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.
		445	.						.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.
Predicted Secondary structure				.	.	.	.	.
Query SS confidence				.	.	.	.	.
Query Sequence		I	V	.	.	.	.	.	N	L	K	L	S	K	G	Q	K	K	R	V	A	L	L	L	A	L	A	E	E	R	D	I	I	L	L	D	E	W	A	A	D	Q	D	P	H	F	R	R	E	F	Y	Q	V	L	L	P	L	M	Q	E	M	G	K	T	I	F	A	I	S	H	D	D	H	Y	F	I	H	A	D	R	L
Query Conservation				.	.	.	.	.
Alig confidence				.	.	.	.	.																																																		.	.
Template Conservation																																																										.	.
Template Sequence		D	T	L	V	G	E	R	G	A	Q	L	S	G	G	Q	K	Q	R	I	A	I	A	R	A	L	V	R	N	P	K	I	L	L	L	D	E	A	T	S	A	L	D	T	E	S	E	A	V	V	Q	A	A	L	D	K	A	.	.	R	E	G	R	T	T	I	V	I	A	H	R	L	S	T	V	R	N	A	D	V	I
Template Known Secondary structure		G				S	S	S	S		S	S																			S						B	T	T		S	S																.	.	T	T	S	S							S						T	T		S
Template Predicted Secondary structure																																																										.	.
Template SS confidence
		517	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.			.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.
		520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	E	M	R	N	G	Q	L	S	E	L	T	G	E	E	R	D	A	A	S	R	D	A	V	A	R	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	G	F	D	G	G	V	I	V	E	Q	G	N	H	D	E	L	M	R	E	K	G	I	Y	F	K	L
Template Known Secondary structure					S	S	S															T	S
Template Predicted Secondary structure
Template SS confidence
		595	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.