|   |
18 | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |
|  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
S | P | V | V | F | A | A | D | E | Q | T | M | I | V | S | A | A | P | Q | V | V | S | E | L | D | T | P | A | A | V | S | V | V | D | G | E | E | M | R | L | A | T | P | R | I | N | L | S | E | S | L | T | G | V | P | G | L | Q | V | Q | N | R | Q | N | Y | A | Q | D | L | Q | L | S | I | R | G | F | G | S | R | S |
Query Conservation |   |
  |   |   |   |   |
|   |   |   |
|   |
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |
|   |
|
|   |
|
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |
|
|
|   |
|   |   |   |   |
|   |   |   |   |   |   |
|   |
|
|
|   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |
|   |
|
|
|
|
|   |   |   |   |
|   |   |   | . |   |   |   |   |
|   |
|   |
|   |   |   |
|
|
|   |
|   |   |   |   |
| . | . |   |   |   |   |
|   |
|
|
|   |   |   |   | . |
Template Sequence |   |
I | T | E | D | S | G | S | Y | T | P | G | T | I | A | T | A | T | R | L | V | L | T | P | R | E | T | P | Q | S | I | T | V | V | T | R | Q | N | M | D | D | F | . |
G | L | N | N | I | D | D | V | M | R | H | T | P | G | I | T | V | S | A | Y | D | T | . |
. |
D | R | N | N | Y | Y | A | R | G | F | S | I | N | . |
Template Known Secondary structure |   |
|
| T | T |
|
|
| S | S |
| S |
| B |
| S | S | S | S | S |
| B |
| G | G | G |
|
| S |  |  |  |  |  |  |  |  |  |  |  |  | T | . | T |
|
| B |  |  |  |  |  | T | T | S | T | T |
|  |  |  |  |  |  | T | . | . | T |  |  |  |  |  |  | T | T |  |  |
|
| . |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |
|  |  |  |  |  |  |
| . |
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
| . | . |
|
|
|  |  |  |  |  |  |  |
|
|
| . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | |
. | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | |
|
. | . | . | . | . | . | . | 210 | . | . | . | . | . | |
  |
  |   |
98 | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | |
|
. | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | |
. | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |
|
|  |  |
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|
|
|
|
| . |
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
T | Y | G | I | R | G | I | R | L | Y | V | D | G | I | P | A | T | M | P | . |
. |
D | G | Q | G | Q | T | S | N | I | D | L | S | S | V | Q | N | V | E | V | L | R | G | P | F | S | A | L | Y | G | . |
N | A | S | G | G | V | M | N | V | T | T | Q | T | G | Q | Q | P | P | T | I | E | A | S | S | Y | Y | G | S | F |
Query Conservation |   |
  |   |   |   |   |   |
|   |
|   |
|
|
|   |   |   |   |   |   | . | . |   |   |   |   |   |   |   |   |
|   |   |   |   |
|
|   |
|
|
|
|
|
|   |   |
|   |   |
|
| . |   |   |   |   |
|   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
. | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
. | . | . | . | . | . | . |   |
|   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|
|   |
|
|
|
|
|
|   |   |
|
|   |
|
|   |   |
|   |
|
|
|
|
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
N | F | Q | Y | D | G | I | P | S | T | A | R | N | V | G | Y | S | A | G | N | T | L | S | D | M | A | I | Y | D | R | V | E | V | L | K | G | A | T | G | L | L | T | G | A | G | S | L | G | A | T | I | N | L | I | R | K | K | P | T | H | E | F | K | G | H | V | E | L | G | A | G | S | W |
Template Known Secondary structure |   |
. | . | . | . | . | . | . |
|  |  |  | T | T |  |  |
|
|
|
|
| G | G | G |
|
| S | T | T | S |
| B | G | G | G |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |
| S |
|
| S |  |  |  |  |  |  |  |  |
|
|
|
| S | S |
|  |  |  |  |  |  |  |  |  | T | T |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . |
|  |  |  |
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
216 | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . |
  |
  |   |
175 | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . |
Predicted Secondary structure |   |
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|  |  |
|
|
|
|  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
G | S | W | R | Y | G | L | K | A | T | G | A | T | G | D | G | T | Q | P | G | D | V | D | Y | T | V | S | T | T | R | F | T | T | H | G | Y | R | D | H | S | G | A | Q | K | N | L | A | N | A | K | L | G | V | R | I | D | E | A | S | K | L | S | L | I | F | N | S | V | D | I | K | A | D | D | P | G | G | L | T | K |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
D | N | Y | R | S | E | L | D | V | S | G | P | L | T | E | S | . |
. |
. |
G | N | V | R | G | R | A | V | A | A | Y | Q | D | K | H | S | F | M | D | H | Y | E | R | K | T | S | V | Y | Y | G | I | L | E | F | D | L | N | P | D | T | M | L | T | V | G | A | D | Y | Q | D | N | D | P | K | G | S | G | W | S | G | S |
Template Known Secondary structure |   |
T |  |  |  |  |  |  |  |  |  |  |  |
| S | S | S | . | . | . |
| S |  |  |  |  |  |  |  |  |  |  |  |  |  |
| S | S | T | T |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S |
|
|
| S | S | S |
Template Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
| . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |
|  |  |  |  |
|
|
|
|
|
|  |  |
|
|
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
289 | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | |
|
|
. | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . |
  |
  |   |
255 | . | . | . | . | 260 | . | |
|
|
|
|
|
. | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | E | W | K | A | N | P | . |
. |
. |
. |
. |
. |
Q | Q | A | P | R | A | E | Q | Y | D | T | R | K | T | I | K | Q | T | Q | A | G | L | R | Y | E | R | S | L | S | S | R | D | D | M | S | V | M | M | Y | A | G | E | R | E | T | T | Q | Y | Q | S | I | P | M | A | P | Q | L | N | P | S | H | A | G | G | V | I | T |
Query Conservation |   |
  |   |   |   |   |   |   | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
F | P | L | F | D | S | Q | G | N | R | N | D | V | S | R | S | F | N | N | G | A | K | W | S | S | W | E | Q | Y | T | R | T | V | F | A | N | L | E | H | N | F | A | N | G | W | V | G | K | V | Q | L | D | H | K | I | N | G | Y | H | A | P | L | G | A | I | M | G | D | W | P | A | P | D | N | S | A | K | I | V | A |
Template Known Secondary structure |   |
 |  | S | S | B | T | T | B | S |
|
|
|
|
| T | T |
|
|
| B |
| T | T |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| T | T | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| S | S |
|
|
| T | T | S |
|  |  |  |  |  |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
366 | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . |
  |
  |   |
329 | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | |
|
|
|
|
. | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . |
Predicted Secondary structure |   |
 |
|
|
|  |  |  |  |
|
|  |  |  |
|
|
|
|
| . | . | . | . | . |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
L | Q | R | H | Y | Q | G | I | D | S | R | W | T | H | R | G | E | L | . |
. |
. |
. |
. |
G | V | P | V | T | F | T | T | G | L | N | Y | E | N | M | S | E | N | R | K | G | Y | N | N | F | R | L | N | S | G | M | P | E | Y | G | Q | K | G | E | L | R | R | D | E | R | N | L | M | W | N | I | D | P | Y | L | Q | T |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . | . |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
Q | K | Y | T | G | E | T | K | S | N | S | L | D | I | Y | L | T | G | P | F | Q | F | L | G | R | E | H | E | L | V | V | G | T | S | A | S | F | S | H | W | E | G | K | S | Y | W | N | L | R | N | Y | D | N | T | T | D | D | F | I | N | W | D | G | D | I | G | K | P | D | W | G | T | P | S | Q | Y | I | D | D | K |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  | S |
| S | T | T |
|
| S |
|
|
|
|
|
|
|
| S |
| S |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
446 | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . |
  |
  |   |
404 | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
Q | W | Q | L | S | E | K | L | S | L | D | A | G | V | R | Y | S | S | V | W | F | D | S | N | D | H | Y | V | T | P | G | N | G | D | D | S | G | D | A | S | Y | H | K | W | L | P | A | G | S | L | K | Y | A | M | T | D | A | W | N | I | Y | L | A | A | G | R | G | F | E | T | P | T | I | N | E | L | S | Y | R | A |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . |   |   |
Template Sequence |   |
T | R | Q | L | G | S | Y | M | T | A | R | F | N | V | T | D | D | L | N | L | F | L | G | G | R | V | V | D | Y | R | V | T | G | L | N | P | T | I | R | E | S | G | R | F | I | P | Y | V | G | A | V | Y | D | L | N | D | T | Y | S | V | Y | A | S | Y | T | D | I | F | M | P | Q | . |
. |
. |
. |
. |
. |
. |
D | S |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |
|
| S | S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S | S | S |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . |
| T |
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|  |  |  |
|
|
|
|
|
|
|
|  |  |
|
|  |  |  |
|
|
|
|
|
|  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
526 | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | |
|
|
|
|
|
|
. | . |
  |
  |   |
484 | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | |
|
510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|  |  |  |  |
| . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  | . | . | . | . | . | . |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
D | G | Q | S | G | M | N | L | G | L | K | P | S | T | N | D | T | I | E | I | G | S | K | T | R | I | . |
. |
G | D | G | L | L | S | L | A | L | F | Q | T | D | T | D | D | E | I | V | V | . |
. |
. |
. |
. |
. |
D | S | S | S | G | G | R | T | T | Y | K | N | A | G | K | T | R | R | Q | G | A | E | L | A | W | D |
Query Conservation |   |
  |   |   |   |   |   |
|   |   |
|   |   |
|   |   |   |   |   |
|   |
|   |   |   |   |   | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |
|   |   |
|   |
|
|   |   |   |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |   |
|   |
|
|   |   |   |
Template Sequence |   |
W | Y | R | D | S | S | N | K | L | L | E | P | D | E | G | Q | N | Y | E | I | G | I | K | G | E | Y | L | D | G | R | L | N | T | S | L | A | Y | F | E | I | H | E | E | N | R | A | E | E | D | A | L | Y | N | S | K | P | T | N | P | A | I | T | Y | A | Y | K | G | I | K | A | K | T | K | G | Y | E | A | E | I | S |
Template Known Secondary structure |   |
T |
| B |
| T | T | S |
| B |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | G | G | G | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  | T | S |
|
|
| T | T |
| S | S |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
599 | 600 | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660 | . | . | . | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . | . |
  |
  |   |
556 | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600 | . | . | . | . | . | . | . | |
|
|
. | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | |
|
|
Predicted Secondary structure |   |
 |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
| . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
| . | . | . |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
Query Sequence |   |
Q | R | F | A | G | D | F | R | V | N | A | S | W | T | W | L | D | A | T | Y | R | S | N | V | C | N | E | Q | D | C | N | G | N | R | M | P | G | I | A | R | N | M | G | F | A | S | I | G | Y | V | P | E | . |
. |
. |
D | G | W | Y | A | G | T | E | A | R | Y | M | G | D | I | M | A | D | D | E | N | T | . |
. |
. |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |
|   |   |   | . | . | . |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   | . | . | . |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
G | E | L | A | P | G | W | Q | V | Q | A | G | Y | T | H | K | I | I | R | D | D | S | . |
. |
. |
. |
. |
. |
. |
. |
G | K | K | V | S | T | W | E | P | Q | D | Q | L | S | L | Y | T | S | Y | K | F | K | G | A | L | D | K | L | T | V | G | G | G | A | R | W | Q | G | K | S | W | Q | M | V | Y | N | N | P | R | S |
Template Known Secondary structure |   |
 |  |  |  | T | T |  |  |  |  |  |  |  |  |  |
|
|  |  |
| S | S | . | . | . | . | . | . | . | . | S |
| B |
|
| T | T | S |
| S |  |  |  |  |  |  |  |  |  |  |
|
| G | G | G | T | T |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  | T | T | T | T |
Template Predicted Secondary structure |   |
 |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
679 | 680 | . | . | . | . | . | . | . | . | . | 690 | . | . | . | . | . | . | . | . | . | 700 | |
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | . | 710 | . | . | . | . | . | . | . | . | . | 720 | . | . | . | . | . | . | . | . | . | 730 | . | . | . | . | . | . | . | . | . | 740 | . | . | . | . | . | . | . | . | . | 750 |
  |
  |   |
|
|
|
|
630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660 | . | . | . | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . | . | . | 680 | . | . | . | . | . | . | . | . | . | 690 | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
. | . | . | . |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
. |
. |
. |
. |
A | K | A | P | S | Y | T | L | V | G | L | F | T | G | Y | K | Y | N | Y | H | N | L | T | V | D | L | F | G | R | V | D | N | L | F | D | K | E | Y | V | G | S | V | I | V | N | E | S | N | G | R | Y | Y | E | P | S | P | G | R | N | Y | G | V | G | M | N | I | A | W |
Query Conservation |   |
. | . | . | . |   |   |   |   |   |
|   |   |   |
|
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |
|
|   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |
|
Alig confidence |   |
. | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |
|   |   |   |
|
|   |   |   |
|   |   |   |   |   | . | . | . |   |   |
|   |
|   |
|   |
|
|   |
|   |   |
|   |   |   |   |   |   |   |   |   | . | . | . | . |   |   |   |   |   |
|
|   |   |   |
|   |   |   |
|   |
|
Template Sequence |   |
R | W | E | K | F | S | Q | E | D | Y | W | L | V | D | L | M | A | R | Y | Q | I | T | D | K | . |
. |
. |
L | S | A | S | V | N | V | N | N | V | F | D | K | T | Y | Y | T | N | I | G | F | Y | T | S | . |
. |
. |
. |
A | S | Y | G | D | P | R | N | L | M | F | S | T | R | W | D | F |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
| S | S | S | . | . | . |
|  |  |  |  |  |  |  | S | T | T |
|
|
|
|  |  |  |
| T | G | G | G |  | . | . | . | . |  |  |  |
|
|
| S |  |  |  |  |  |  |  |
|
|
|
Template Predicted Secondary structure |   |
|
|
|
|  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| . | . | . |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
| . | . | . | . |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
751 | . | . | . | . | . | . | . | . | 760 | . | . | . | . | . | . | . | . | . | 770 | . | . | . | . | |
|
|
. | . | . | . | . | 780 | . | . | . | . | . | . | . | . | . | 790 | . | . | . | . | . | . | . | . | |
|
|
|
. | 800 | . | . | . | . | . | . | . | . | . | 810 | . | . | . | . | . |
  |