Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	E	T	I	T	H	G	A	E	W	F	I	G	L	F	Q	K	G	G	E	V	F	T	G	M	V	T	G	I	L	P	L	L	I	S	L	L	V	I	M	N	A	L	I	N	F	I	G	Q	H	R	I	E	R	F	A	Q	R	C
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	N	P	V	S	R	Y	L	L	L	P	C	I	G	T	F	V	F	C	N	P	M	T	L	S	L	G	R	F	M	P	E	K	Y	K	P	S	Y	Y	A	A	A	S	Y	S	C	H	S	M	N	G	L	F	P	H	I	N	P	G
Secondary structure
SS confidence
Disorder						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	L	F	V	Y	L	G	I	A	S	G	L	T	T	L	N	L	P	L	G	P	L	A	V	S	Y	L	L	V	G	L	V	T	N	F	F	R	G	W	V	T	D	L	T	T	A	I	F	E	K	K	M	G	I	Q	L	E	Q	K	V
Secondary structure
SS confidence
Disorder																?	?	?	?	?																																	?			?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		H	L	A	G	A	T	S
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2g3v chain C Region: 43 - 100 Aligned: 58 Modelled: 56 Confidence: 16.7% Identity: 21% PDB header:unknown function Chain: C: PDB Molecule:cag pathogenicity island protein 13; PDBTitle: crystal structure of cags (hp0534, cag13) from helicobacter2 pylori Phyre2 PDB 2zsh chain B Region: 116 - 127 Aligned: 12 Modelled: 12 Confidence: 11.9% Identity: 50% PDB header:hormone receptor Chain: B: PDB Molecule:della protein gai; PDBTitle: structural basis of gibberellin(ga3)-induced della2 recognition by the gibberellin receptor Phyre2 PDB 1wpg chain A domain 4 Region: 12 - 62 Aligned: 48 Modelled: 51 Confidence: 11.8% Identity: 23% Fold: Calcium ATPase, transmembrane domain M Superfamily: Calcium ATPase, transmembrane domain M Family: Calcium ATPase, transmembrane domain M Phyre2 PDB 2inc chain B domain 1 Region: 82 - 109 Aligned: 27 Modelled: 28 Confidence: 10.5% Identity: 22% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1kf6 chain D Region: 12 - 80 Aligned: 60 Modelled: 64 Confidence: 10.1% Identity: 35% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 3e9v chain A domain 1 Region: 39 - 68 Aligned: 30 Modelled: 30 Confidence: 8.0% Identity: 13% Fold: BTG domain-like Superfamily: BTG domain-like Family: BTG domain-like Phyre2 PDB 1p58 chain C Region: 120 - 156 Aligned: 30 Modelled: 37 Confidence: 7.4% Identity: 37% PDB header:virus Chain: C: PDB Molecule:major envelope protein e; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 1w2z chain A domain 3 Region: 104 - 118 Aligned: 15 Modelled: 15 Confidence: 6.4% Identity: 7% Fold: Cystatin-like Superfamily: Amine oxidase N-terminal region Family: Amine oxidase N-terminal region Phyre2 PDB 1w6g chain A domain 3 Region: 104 - 118 Aligned: 15 Modelled: 15 Confidence: 5.9% Identity: 27% Fold: Cystatin-like Superfamily: Amine oxidase N-terminal region Family: Amine oxidase N-terminal region Phyre2 PDB 2o01 chain D Region: 84 - 115 Aligned: 32 Modelled: 32 Confidence: 5.7% Identity: 28% PDB header:photosynthesis Chain: D: PDB Molecule:photosystem i reaction center subunit ii, PDBTitle: the structure of a plant photosystem i supercomplex at 3.42 angstrom resolution Phyre2 PDB 2a3z chain C Region: 171 - 178 Aligned: 8 Modelled: 8 Confidence: 5.6% Identity: 50% PDB header:structural protein Chain: C: PDB Molecule:wiskott-aldrich syndrome protein; PDBTitle: ternary complex of the wh2 domain of wasp with actin-dnase i Phyre2 PDB 2z15 chain A domain 1 Region: 39 - 68 Aligned: 30 Modelled: 30 Confidence: 5.6% Identity: 20% Fold: BTG domain-like Superfamily: BTG domain-like Family: BTG domain-like Phyre2 PDB 1d6z chain A domain 3 Region: 104 - 118 Aligned: 15 Modelled: 15 Confidence: 5.4% Identity: 20% Fold: Cystatin-like Superfamily: Amine oxidase N-terminal region Family: Amine oxidase N-terminal region Phyre2 PDB 2p7t chain C domain 1 Region: 130 - 146 Aligned: 17 Modelled: 17 Confidence: 5.4% Identity: 29% Fold: Voltage-gated potassium channels Superfamily: Voltage-gated potassium channels Family: Voltage-gated potassium channels Phyre2 PDB 1hlm chain A Region: 35 - 102 Aligned: 66 Modelled: 68 Confidence: 5.1% Identity: 8% Fold: Globin-like Superfamily: Globin-like Family: Globins Phyre2 PDB 2wse chain D Region: 84 - 115 Aligned: 32 Modelled: 32 Confidence: 5.1% Identity: 34% PDB header:photosynthesis Chain: D: PDB Molecule:photosystem i reaction center subunit ii, PDBTitle: improved model of plant photosystem i Phyre2 1 c2g3vC_ 2 c2zshB_ 3 d1wpga4 4 d2incb1 5 d1kf6d_ 6 d3e9va1 7 c1p58C_ 8 d1w2za3 9 d1w6ga3 10 c2o01D_ 11 c2a3zC_ 12 d2z15a1 13 d1d6za3 14 d2p7tc1 15 d1hlma_ 16 c2wseD_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2g3vC_ 16.7 21 PDB header:unknown function Chain: C: PDB Molecule:cag pathogenicity island protein 13; PDBTitle: crystal structure of cags (hp0534, cag13) from helicobacter2 pylori 2 c2zshB_ 11.9 50 PDB header:hormone receptor Chain: B: PDB Molecule:della protein gai; PDBTitle: structural basis of gibberellin(ga3)-induced della2 recognition by the gibberellin receptor 3 d1wpga4 11.8 23 Fold:Calcium ATPase, transmembrane domain M Superfamily:Calcium ATPase, transmembrane domain M Family:Calcium ATPase, transmembrane domain M 4 d2incb1 10.5 22 Fold:Ferritin-like Superfamily:Ferritin-like Family:Ribonucleotide reductase-like 5 d1kf6d_ 10.1 35 Fold:Heme-binding four-helical bundle Superfamily:Fumarate reductase respiratory complex transmembrane subunits Family:Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) 6 d3e9va1 8.0 13 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 7 c1p58C_ 7.4 37 PDB header:virus Chain: C: PDB Molecule:major envelope protein e; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction 8 d1w2za3 6.4 7 Fold:Cystatin-like Superfamily:Amine oxidase N-terminal region Family:Amine oxidase N-terminal region 9 d1w6ga3 5.9 27 Fold:Cystatin-like Superfamily:Amine oxidase N-terminal region Family:Amine oxidase N-terminal region 10 c2o01D_ 5.7 28 PDB header:photosynthesis Chain: D: PDB Molecule:photosystem i reaction center subunit ii, PDBTitle: the structure of a plant photosystem i supercomplex at 3.42 angstrom resolution 11 c2a3zC_ 5.6 50 PDB header:structural protein Chain: C: PDB Molecule:wiskott-aldrich syndrome protein; PDBTitle: ternary complex of the wh2 domain of wasp with actin-dnase i 12 d2z15a1 5.6 20 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 13 d1d6za3 5.4 20 Fold:Cystatin-like Superfamily:Amine oxidase N-terminal region Family:Amine oxidase N-terminal region 14 d2p7tc1 5.4 29 Fold:Voltage-gated potassium channels Superfamily:Voltage-gated potassium channels Family:Voltage-gated potassium channels 15 d1hlma_ 5.1 8 Fold:Globin-like Superfamily:Globin-like Family:Globins 16 c2wseD_ 5.1 34 PDB header:photosynthesis Chain: D: PDB Molecule:photosystem i reaction center subunit ii, PDBTitle: improved model of plant photosystem i

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0