Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	S	K	D	T	L	K	W	F	P	A	Q	L	P	E	V	R	I	I	L	G	D	A	V	V	E	V	A	K	Q	G	R	P	I	N	T	R	T	L	L	D	Y	I	E	G	N	I	K	K	T	S	W	L	D	N	K	E	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																							?		?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.
Sequence		Q	T	A	I	S	V	L	K	D	N	Q	N	L	N	G	K	M
Secondary structure
SS confidence
Disorder									?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1wq6 chain A Region: 36 - 72 Aligned: 28 Modelled: 37 Confidence: 42.0% Identity: 29% PDB header:oncoprotein Chain: A: PDB Molecule:aml1-eto; PDBTitle: the tetramer structure of the nervy homolgy two (nhr2) domain of aml1-2 eto is critical for aml1-eto's activity Phyre2 PDB 2kk1 chain A Region: 24 - 70 Aligned: 39 Modelled: 47 Confidence: 38.4% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase abl2; PDBTitle: solution structure of c-terminal domain of tyrosine-protein2 kinase abl2 from homo sapiens, northeast structural3 genomics consortium (nesg) target hr5537a Phyre2 PDB 1zzp chain A Region: 24 - 70 Aligned: 39 Modelled: 47 Confidence: 26.1% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1; PDBTitle: solution structure of the f-actin binding domain of bcr-2 abl/c-abl Phyre2 PDB 1a11 chain A Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 23.1% Identity: 70% PDB header:acetylcholine receptor Chain: A: PDB Molecule:acetylcholine receptor m2; PDBTitle: nmr structure of membrane spanning segment 2 of the2 acetylcholine receptor in dpc micelles, 10 structures Phyre2 PDB 1eq8 chain C Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 18.8% Identity: 70% PDB header:signaling protein Chain: C: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain E Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 18.8% Identity: 70% PDB header:signaling protein Chain: E: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain A Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 18.8% Identity: 70% PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain D Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 18.8% Identity: 70% PDB header:signaling protein Chain: D: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1eq8 chain B Region: 58 - 67 Aligned: 10 Modelled: 10 Confidence: 18.8% Identity: 70% PDB header:signaling protein Chain: B: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment Phyre2 PDB 1m5q chain 1 Region: 19 - 45 Aligned: 27 Modelled: 27 Confidence: 10.5% Identity: 22% Fold: Sm-like fold Superfamily: Sm-like ribonucleoproteins Family: Sm motif of small nuclear ribonucleoproteins, SNRNP Phyre2 PDB 2fna chain A domain 1 Region: 29 - 49 Aligned: 21 Modelled: 21 Confidence: 8.7% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Helicase DNA-binding domain Phyre2 PDB 3e0z chain B Region: 35 - 58 Aligned: 24 Modelled: 23 Confidence: 8.4% Identity: 29% PDB header:unknown function Chain: B: PDB Molecule:protein of unknown function; PDBTitle: crystal structure of a putative imidazole glycerol phosphate synthase2 homolog (eubrec_1070) from eubacterium rectale at 1.75 a resolution Phyre2 PDB 1izl chain J Region: 31 - 37 Aligned: 7 Modelled: 7 Confidence: 5.7% Identity: 57% PDB header:photosynthesis Chain: J: PDB Molecule:photosystem ii: subunit psba; PDBTitle: crystal structure of photosystem ii Phyre2 PDB 1dfw chain A Region: 38 - 50 Aligned: 13 Modelled: 13 Confidence: 5.6% Identity: 38% PDB header:immune system Chain: A: PDB Molecule:lung surfactant protein b; PDBTitle: conformational mapping of the n-terminal segment of2 surfactant protein b in lipid using 13c-enhanced fourier3 transform infrared spectroscopy (ftir) Phyre2 PDB 1mu2 chain A Region: 12 - 50 Aligned: 38 Modelled: 39 Confidence: 5.3% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:hiv-2 rt; PDBTitle: crystal structure of hiv-2 reverse transcriptase Phyre2 PDB 3blh chain B domain 1 Region: 38 - 69 Aligned: 26 Modelled: 32 Confidence: 5.2% Identity: 15% Fold: Cyclin-like Superfamily: Cyclin-like Family: Cyclin Phyre2 PDB 3ctd chain B Region: 14 - 29 Aligned: 16 Modelled: 16 Confidence: 5.1% Identity: 31% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative atpase, aaa family; PDBTitle: crystal structure of a putative aaa family atpase from2 prochlorococcus marinus subsp. pastoris Phyre2 1 c1wq6A_ 2 c2kk1A_ 3 c1zzpA_ 4 c1a11A_ 5 c1eq8C_ 6 c1eq8E_ 7 c1eq8A_ 8 c1eq8D_ 9 c1eq8B_ 10 d1m5q1_ 11 d2fnaa1 12 c3e0zB_ 13 c1izlJ_ 14 c1dfwA_ 15 c1mu2A_ 16 d3blhb1 17 c3ctdB_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1wq6A_ 42.0 29 PDB header:oncoprotein Chain: A: PDB Molecule:aml1-eto; PDBTitle: the tetramer structure of the nervy homolgy two (nhr2) domain of aml1-2 eto is critical for aml1-eto's activity 2 c2kk1A_ 38.4 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase abl2; PDBTitle: solution structure of c-terminal domain of tyrosine-protein2 kinase abl2 from homo sapiens, northeast structural3 genomics consortium (nesg) target hr5537a 3 c1zzpA_ 26.1 31 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1; PDBTitle: solution structure of the f-actin binding domain of bcr-2 abl/c-abl 4 c1a11A_ 23.1 70 PDB header:acetylcholine receptor Chain: A: PDB Molecule:acetylcholine receptor m2; PDBTitle: nmr structure of membrane spanning segment 2 of the2 acetylcholine receptor in dpc micelles, 10 structures 5 c1eq8C_ 18.8 70 PDB header:signaling protein Chain: C: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 6 c1eq8E_ 18.8 70 PDB header:signaling protein Chain: E: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 7 c1eq8A_ 18.8 70 PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 8 c1eq8D_ 18.8 70 PDB header:signaling protein Chain: D: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 9 c1eq8B_ 18.8 70 PDB header:signaling protein Chain: B: PDB Molecule:acetylcholine receptor protein; PDBTitle: three-dimensional structure of the pentameric helical2 bundle of the acetylcholine receptor m2 transmembrane3 segment 10 d1m5q1_ 10.5 22 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Sm motif of small nuclear ribonucleoproteins, SNRNP 11 d2fnaa1 8.7 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Helicase DNA-binding domain 12 c3e0zB_ 8.4 29 PDB header:unknown function Chain: B: PDB Molecule:protein of unknown function; PDBTitle: crystal structure of a putative imidazole glycerol phosphate synthase2 homolog (eubrec_1070) from eubacterium rectale at 1.75 a resolution 13 c1izlJ_ 5.7 57 PDB header:photosynthesis Chain: J: PDB Molecule:photosystem ii: subunit psba; PDBTitle: crystal structure of photosystem ii 14 c1dfwA_ 5.6 38 PDB header:immune system Chain: A: PDB Molecule:lung surfactant protein b; PDBTitle: conformational mapping of the n-terminal segment of2 surfactant protein b in lipid using 13c-enhanced fourier3 transform infrared spectroscopy (ftir) 15 c1mu2A_ 5.3 16 PDB header:transferase Chain: A: PDB Molecule:hiv-2 rt; PDBTitle: crystal structure of hiv-2 reverse transcriptase 16 d3blhb1 5.2 15 Fold:Cyclin-like Superfamily:Cyclin-like Family:Cyclin 17 c3ctdB_ 5.1 31 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative atpase, aaa family; PDBTitle: crystal structure of a putative aaa family atpase from2 prochlorococcus marinus subsp. pastoris

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0