Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	R	R	L	R	F	S	G	P	K	T	S	I	I	C	S	P	M	T	S	L	K	T	S	I	K	T	I	T	Y	L	S	D	I	G	C	L	E	I	Q	G	A	S	L	A	G	S	G	S	G	G	E	H	A	A	V	L	Y	S
Secondary structure
SS confidence
Disorder		?	?	?				?										?	?						?									?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.
Sequence		L	I	G	T	C	R	L	N	N	V	E	L	E	K	W	L	C	Y	G	I	E	H	I	Q	D	W	S	A	N	L	V	R	D	L
Secondary structure
SS confidence
Disorder																																	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1o98 chain A domain 1 Region: 7 - 91 Aligned: 71 Modelled: 71 Confidence: 17.9% Identity: 18% Fold: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Superfamily: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Family: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Phyre2 PDB 2k5e chain A Region: 60 - 86 Aligned: 27 Modelled: 27 Confidence: 17.8% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of putative uncharacterized protein2 gsu1278 from methanocaldococcus jannaschii, northeast3 structural genomics consortium (nesg) target gsr195 Phyre2 PDB 2qnf chain B Region: 65 - 92 Aligned: 28 Modelled: 28 Confidence: 17.1% Identity: 18% PDB header:hydrolase/dna Chain: B: PDB Molecule:recombination endonuclease vii; PDBTitle: crystal structure of t4 endonuclease vii h43n mutant in2 complex with heteroduplex dna containing base mismatches Phyre2 PDB 2bby chain A Region: 72 - 89 Aligned: 18 Modelled: 18 Confidence: 16.7% Identity: 11% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: DNA-binding domain from rap30 Phyre2 PDB 2iqc chain A Region: 65 - 85 Aligned: 21 Modelled: 21 Confidence: 15.0% Identity: 24% PDB header:protein binding Chain: A: PDB Molecule:fanconi anemia group f protein; PDBTitle: crystal structure of human fancf protein that functions in2 the assembly of a dna damage signaling complex Phyre2 PDB 2k53 chain A Region: 60 - 85 Aligned: 26 Modelled: 26 Confidence: 13.6% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:a3dk08 protein; PDBTitle: nmr solution structure of a3dk08 protein from clostridium2 thermocellum: northeast structural genomics consortium3 target cmr9 Phyre2 PDB 2ebf chain X domain 2 Region: 58 - 70 Aligned: 13 Modelled: 13 Confidence: 10.5% Identity: 23% Fold: EreA/ChaN-like Superfamily: EreA/ChaN-like Family: PMT domain-like Phyre2 PDB 5mdh chain A domain 1 Region: 71 - 91 Aligned: 21 Modelled: 21 Confidence: 10.2% Identity: 5% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: LDH N-terminal domain-like Phyre2 PDB 2khz chain B Region: 39 - 69 Aligned: 31 Modelled: 31 Confidence: 8.6% Identity: 19% PDB header:nuclear protein Chain: B: PDB Molecule:c-myc-responsive protein rcl; PDBTitle: solution structure of rcl Phyre2 PDB 3crc chain B Region: 52 - 83 Aligned: 32 Modelled: 32 Confidence: 7.6% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:protein mazg; PDBTitle: crystal structure of escherichia coli mazg, the regulator2 of nutritional stress response Phyre2 PDB 3s9v chain D Region: 34 - 85 Aligned: 44 Modelled: 52 Confidence: 6.5% Identity: 18% PDB header:lyase, isomerase Chain: D: PDB Molecule:abietadiene synthase, chloroplastic; PDBTitle: abietadiene synthase from abies grandis Phyre2 PDB 2auh chain B Region: 5 - 22 Aligned: 18 Modelled: 18 Confidence: 5.8% Identity: 39% PDB header:transferase/signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 bps region in complex with2 the insulin receptor tyrosine kinase Phyre2 PDB 2vy2 chain A Region: 47 - 77 Aligned: 31 Modelled: 31 Confidence: 5.7% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:protein leafy; PDBTitle: structure of leafy transcription factor from arabidopsis2 thaliana in complex with dna from ag-i promoter Phyre2 1 d1o98a1 2 c2k5eA_ 3 c2qnfB_ 4 d2bbya_ 5 c2iqcA_ 6 c2k53A_ 7 d2ebfx2 8 d5mdha1 9 c2khzB_ 10 c3crcB_ 11 c3s9vD_ 12 c2auhB_ 13 c2vy2A_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1o98a1 17.9 18 Fold:2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Superfamily:2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Family:2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain 2 c2k5eA_ 17.8 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of putative uncharacterized protein2 gsu1278 from methanocaldococcus jannaschii, northeast3 structural genomics consortium (nesg) target gsr195 3 c2qnfB_ 17.1 18 PDB header:hydrolase/dna Chain: B: PDB Molecule:recombination endonuclease vii; PDBTitle: crystal structure of t4 endonuclease vii h43n mutant in2 complex with heteroduplex dna containing base mismatches 4 d2bbya_ 16.7 11 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DNA-binding domain from rap30 5 c2iqcA_ 15.0 24 PDB header:protein binding Chain: A: PDB Molecule:fanconi anemia group f protein; PDBTitle: crystal structure of human fancf protein that functions in2 the assembly of a dna damage signaling complex 6 c2k53A_ 13.6 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:a3dk08 protein; PDBTitle: nmr solution structure of a3dk08 protein from clostridium2 thermocellum: northeast structural genomics consortium3 target cmr9 7 d2ebfx2 10.5 23 Fold:EreA/ChaN-like Superfamily:EreA/ChaN-like Family:PMT domain-like 8 d5mdha1 10.2 5 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 9 c2khzB_ 8.6 19 PDB header:nuclear protein Chain: B: PDB Molecule:c-myc-responsive protein rcl; PDBTitle: solution structure of rcl 10 c3crcB_ 7.6 19 PDB header:hydrolase Chain: B: PDB Molecule:protein mazg; PDBTitle: crystal structure of escherichia coli mazg, the regulator2 of nutritional stress response 11 c3s9vD_ 6.5 18 PDB header:lyase, isomerase Chain: D: PDB Molecule:abietadiene synthase, chloroplastic; PDBTitle: abietadiene synthase from abies grandis 12 c2auhB_ 5.8 39 PDB header:transferase/signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 bps region in complex with2 the insulin receptor tyrosine kinase 13 c2vy2A_ 5.7 13 PDB header:transcription Chain: A: PDB Molecule:protein leafy; PDBTitle: structure of leafy transcription factor from arabidopsis2 thaliana in complex with dna from ag-i promoter

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0