Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	A	C	L	F	H	C	K	Y	P	G	I	G	N	T	R	I	F	T	E	E	Q	H	N	H	D	G	T	G	L	S	Q	V	V	L	N	A	I	F	N	L	V	C	L	L	Q	V	Y	V	Q	T	S	Y	L	S	Q	Q	S	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?															?	?	?	?	?	?	?	?	?	?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70
Sequence		I	I	R	Y	T	A	F	T	G	P
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1o51 chain A Region: 17 - 38 Aligned: 22 Modelled: 22 Confidence: 18.4% Identity: 23% Fold: Ferredoxin-like Superfamily: GlnB-like Family: DUF190/COG1993 Phyre2 PDB 2dcl chain B Region: 17 - 38 Aligned: 22 Modelled: 22 Confidence: 12.9% Identity: 27% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical upf0166 protein ph1503; PDBTitle: structure of ph1503 protein from pyrococcus horikoshii ot3 Phyre2 PDB 1bg2 chain A Region: 2 - 43 Aligned: 42 Modelled: 42 Confidence: 11.1% Identity: 21% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Motor proteins Phyre2 PDB 1qmy chain A Region: 14 - 46 Aligned: 28 Modelled: 33 Confidence: 10.1% Identity: 36% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: FMDV leader protease Phyre2 PDB 2dlk chain A domain 1 Region: 8 - 23 Aligned: 14 Modelled: 16 Confidence: 9.9% Identity: 57% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 1qol chain A Region: 14 - 46 Aligned: 28 Modelled: 33 Confidence: 9.6% Identity: 36% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: FMDV leader protease Phyre2 PDB 3b6v chain A Region: 2 - 43 Aligned: 42 Modelled: 42 Confidence: 7.4% Identity: 17% PDB header:motor protein Chain: A: PDB Molecule:kinesin-like protein kif3c; PDBTitle: crystal structure of the motor domain of human kinesin family member2 3c in complex with adp Phyre2 PDB 3fbz chain A Region: 22 - 43 Aligned: 22 Modelled: 22 Confidence: 6.3% Identity: 45% PDB header:structural protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of orf140 of the archaeal virus acidianus2 filamentous virus 1 (afv1) Phyre2 PDB 1zfd chain A Region: 6 - 16 Aligned: 11 Modelled: 11 Confidence: 6.1% Identity: 27% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 3bex chain A domain 1 Region: 13 - 18 Aligned: 6 Modelled: 6 Confidence: 5.6% Identity: 50% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: CoaX-like Phyre2 PDB 2f9w chain A domain 2 Region: 13 - 18 Aligned: 6 Modelled: 6 Confidence: 5.6% Identity: 50% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: CoaX-like Phyre2 PDB 2dlk chain A domain 2 Region: 6 - 24 Aligned: 17 Modelled: 19 Confidence: 5.6% Identity: 35% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 3fia chain A Region: 29 - 43 Aligned: 15 Modelled: 15 Confidence: 5.6% Identity: 47% PDB header:protein binding Chain: A: PDB Molecule:intersectin-1; PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e. Phyre2 PDB 3cgu chain B Region: 5 - 32 Aligned: 28 Modelled: 28 Confidence: 5.5% Identity: 25% PDB header:hormone/signaling protein Chain: B: PDB Molecule:protein giant-lens; PDBTitle: crystal structure of unliganded argos Phyre2 PDB 1mkj chain A Region: 2 - 43 Aligned: 42 Modelled: 42 Confidence: 5.3% Identity: 21% PDB header:transport protein Chain: A: PDB Molecule:kinesin heavy chain; PDBTitle: human kinesin motor domain with docked neck linker Phyre2 1 d1o51a_ 2 c2dclB_ 3 d1bg2a_ 4 d1qmya_ 5 d2dlka1 6 d1qola_ 7 c3b6vA_ 8 c3fbzA_ 9 d1zfda_ 10 d3bexa1 11 d2f9wa2 12 d2dlka2 13 c3fiaA_ 14 c3cguB_ 15 c1mkjA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1o51a_ 18.4 23 Fold:Ferredoxin-like Superfamily:GlnB-like Family:DUF190/COG1993 2 c2dclB_ 12.9 27 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical upf0166 protein ph1503; PDBTitle: structure of ph1503 protein from pyrococcus horikoshii ot3 3 d1bg2a_ 11.1 21 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Motor proteins 4 d1qmya_ 10.1 36 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:FMDV leader protease 5 d2dlka1 9.9 57 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 6 d1qola_ 9.6 36 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:FMDV leader protease 7 c3b6vA_ 7.4 17 PDB header:motor protein Chain: A: PDB Molecule:kinesin-like protein kif3c; PDBTitle: crystal structure of the motor domain of human kinesin family member2 3c in complex with adp 8 c3fbzA_ 6.3 45 PDB header:structural protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of orf140 of the archaeal virus acidianus2 filamentous virus 1 (afv1) 9 d1zfda_ 6.1 27 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 10 d3bexa1 5.6 50 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:CoaX-like 11 d2f9wa2 5.6 50 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:CoaX-like 12 d2dlka2 5.6 35 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 13 c3fiaA_ 5.6 47 PDB header:protein binding Chain: A: PDB Molecule:intersectin-1; PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e. 14 c3cguB_ 5.5 25 PDB header:hormone/signaling protein Chain: B: PDB Molecule:protein giant-lens; PDBTitle: crystal structure of unliganded argos 15 c1mkjA_ 5.3 21 PDB header:transport protein Chain: A: PDB Molecule:kinesin heavy chain; PDBTitle: human kinesin motor domain with docked neck linker

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0