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Job DescriptionP77509
Confidence100.00%DateThu Jan 5 12:30:08 GMT 2012
Rank4Aligned Residues460
% Identity28%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   11........20 .........30.........40.........50.........60.........70.........80.......
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Query Sequence  AKVVAGNKRY. . . PGVVALDNVNFTLNKGEVRALLGKNGAGKSTLIRMLTGSERPDSGDIWIGETRLEGDEATLTRRAAE
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDI. . . . RTINVRYLR
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTG....GGS
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   388.390.........400.........410.........420.........430.........440.........450.... .....460...
 
   88.90.........100.........110.........120.........130....... ..140.........150.........160.....
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Query Sequence  LGVRAVYQELSLVEGLTVAENLCLGQWPRRNGMIDYLQMAQDAQRCLQAL. . GVDVSPEQLVSTLSPAQKQLVEIARVMK
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Template Sequence  EIIGVVSQEPVLFAT. TIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALV
Template Known Secondary structure  SS



SS.

SS

TT
TTSTTGGG


SSSS
SS
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   464.....470........ .480.........490.........500.........510.........520.........530.........540..
 
   166...170.........180.........190.........200.........210.........220.........230.........240.....
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Query Sequence  GEPRVVILDEPTSSLASAEVELVISAVKKMSALGVAVIYVSHRMEEIRRIASCATVMRDGQVAGDVMLENTSTHHIVSLM
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Template Sequence  RNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELMREKGIYFK
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




TS
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   543......550.........560.........570.... .....580......... 590.........600.........610.........620
 
   246.
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Query Sequence  LG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                        
                                         
Template Sequence  LVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLI
Template Known Secondary structure  T









TTT



SS
STT
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   621........630.........640.........650.........660.........670.........680.........690.........700
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation        
                   
   
   
               
 
  
   
           
   
    
Template Sequence  LGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIA
Template Known Secondary structure 

S
S

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   758.760.........770.........780.........790.........800.........810.........820.........830.......
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation        
        
 

 
    
                               
 
 
   

             
Template Sequence  NLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYA
Template Known Secondary structure  SS
STTTT
TTTTT
SS
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   838.840.........850.........860.........870.........880.........890.........900.........910.......
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                        
  
                           
          
Template Sequence  QSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKA
Template Known Secondary structure 

TTTT
S
STTTSSSS
S
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   918.920.........930.........940.........950.........960.........970.........980.........990.......
 
   248.250.........260.........270...... ...280.........290.........300......
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Query Sequence  . . . . . . . . . . . . . . RDHVDIAPVAPQEIVDQAVLEVRALRHKP. . . . . . . KLEDISFTLRRGEVLGIAGLLGAGRSELLK
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Template Sequence  TVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Template Known Secondary structure  S




SS
S




TTT





S
GGG

SS


SSS
SSSTT
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   998.1000.........1010.........1020.........1030.........1040.........1050.........1060.........1070.......
 
   307..310.........320.........330.........340.........350.........360.........370.........380......
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Query Sequence  AIVGLEEYEQGEIVINGEKITRPDYGDMLKRGIGYTPENRKEAGIIPWLGVDENTVLTNRQKISANGVLQWSTIRRLTEE
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Template Sequence  LLERFYDPMAGSVFLDGKEIKQLNVQWL. RAQLGIVSQEP. . . . ILFDCSIAENIAY. . . . . . . . . GDNSRVVSYEEIVR
Template Known Secondary structure  TTSS

SSSSS
BTSS
.TTS
SS
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SSBT
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SS



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   1078.1080.........1090.........1100..... ....1110...... ...1120......... 1130.........1140...
 
   387..390.........400.. .......410.........420.........430.........440.........450......
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Query Sequence  VMQRMTVKAASSETPI. . . . . . . . . . GTLSGGNQQKVVIGRWVYAASQILLLDEPTRGVDIEAKQQIYRIVRELAAEGKS
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Template Sequence  AAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR. EGRT
Template Known Secondary structure  T
SSTTTGGG
B
STTS
SS


SSS
SSS

S.SSS
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   1144.....1150.........1160.........1170.........1180.........1190.........1200.........1210........ .1220..
 
   457..460.........470.........480.........490.......
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Query Sequence  VVFISSEVEELPLVCDRILLLQHGTFSQEFHAPVNVDELMS
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Template Sequence  CIVIAHRLSTIQN. ADLIVVIQNGKVKE. . . . HGTHQQLLA
Template Known Secondary structure 
S
TTGGGS.
STB....
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   1223......1230..... ....1240......... 1250........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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