Job Description P0AES4 Confidence 100.00% Date Thu Jan 5 11:24:06 GMT 2012 Rank 11 Aligned Residues 449 % Identity 25% Template c3qx3B_ PDB info PDB header:isomerase/dna/isomerase inhibitor Chain: B: PDB Molecule:dna topoisomerase 2-beta; PDBTitle: human topoisomerase iibeta in complex with dna and etoposide Resolution 2.16 Å

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		3	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.			.	.	.	.	.	.	80
Predicted Secondary structure																																																																									.	.
Query SS confidence																																																																									.	.
Query Sequence		D	L	A	R	E	I	T	P	V	N	I	E	E	E	L	K	S	S	Y	L	D	Y	A	M	S	V	I	V	G	R	A	L	P	D	V	R	D	G	L	K	P	V	H	R	R	V	L	Y	A	M	N	V	L	G	N	D	W	N	K	A	Y	K	K	S	A	R	V	V	G	D	V	.	.	I	G	K	Y	H	P	H
Query Conservation																																																																									.	.
Alig confidence																														.																											.	.	.														.	.						.
Template Conservation																														.																											.	.	.																					.
Template Sequence		R	R	L	H	G	T	K	H	L	T	Y	N	D	F	I	N	K	E	L	I	L	F	S	N	S	D	N	E	.	R	S	I	P	S	L	V	D	G	F	K	P	G	Q	R	K	V	L	F	T	C	F	K	R	N	D	.	.	.	K	R	E	V	K	V	A	Q	L	A	G	S	V	A	E	M	S	A	Y	H	.	H
Template Known Secondary structure																			T											.			S		B	T	T	T	S																		.	.	.	S	S																T			.	S
Template Predicted Secondary structure																														.																											.	.	.																					.
Template SS confidence
		691	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.		.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.				.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.		.
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.			.	.	.	100	.	.	.	.	.	.	.	.	.	110	.			.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.
Predicted Secondary structure																		.	.																.	.
Query SS confidence																		.	.																.	.
Query Sequence		G	D	S	A	V	Y	D	T	I	V	R	M	A	Q	P	F	.	.	S	L	R	Y	M	L	V	D	G	Q	G	N	F	G	S	.	.	I	D	G	D	S	A	A	A	M	R	Y	T	E	I	R	L	A	K	I	A	H	E	L	M	A	D	L	E	K	E	T	V	D	F	V	D	N	Y	D	G	T	E	K	I	P
Query Conservation																		.	.																.	.
Alig confidence																		.	.																.	.																																						.
Template Conservation																																																																										.
Template Sequence		G	E	Q	A	L	M	M	T	I	V	N	L	A	Q	N	F	V	G	S	N	N	I	N	L	L	Q	P	I	G	Q	F	G	T	R	L	H	G	G	K	D	A	A	S	P	R	Y	I	F	T	M	L	S	T	L	A	R	L	L	F	P	A	V	D	D	N	L	L	K	F	L	Y	D	.	D	N	Q	R	V	E	P
Template Known Secondary structure																	S	T	T	S		S	S		S	B			B	S					T	T	T	T	T	T	T				T	T	S					B		T	T					S		G	G	G	G	G	G	S						.	T	T
Template Predicted Secondary structure																																																																										.
Template SS confidence
		776	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.		.	.	850	.	.	.	.
		157	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.			.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.
Predicted Secondary structure																																																																.	.
Query SS confidence																																																																.	.
Query Sequence		D	V	M	P	T	K	I	P	N	L	L	V	N	G	S	S	G	I	A	V	G	M	A	T	N	I	P	P	H	N	L	T	E	V	I	N	G	C	L	A	Y	I	D	D	E	D	I	S	I	E	G	L	M	E	H	I	P	G	P	D	F	P	.	.	T	A	A	I	I	N	G	R	R	G	I	E	E	A	Y	R
Query Conservation																																																																.	.
Alig confidence																																																		.	.	.	.	.	.	.								.	.					.	.	.	.	.	.	.	.	.	.
Template Conservation																																																		.	.	.	.	.	.	.														.	.	.	.	.	.	.	.	.	.
Template Sequence		E	W	Y	I	P	I	I	P	M	V	L	I	N	G	A	E	G	I	G	T	G	W	A	C	K	L	P	N	Y	D	A	R	E	I	V	N	N	V	R	R	M	L	D	G	L	D	P	H	.	.	.	.	.	.	.	P	M	L	P	N	Y	K	N	F	K	G	T	I	.	.	.	.	.	.	.	.	.	.	Q	E
Template Known Secondary structure		S					S	S						T	T						S	S																						T	T					.	.	.	.	.	.	.							T	T			S			.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																																		.	.	.	.	.	.	.														.	.	.	.	.	.	.	.	.	.
Template SS confidence
		855	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.								.	.	.	.	.	.	.	910	.	.	.	.	.											.	.
		235	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	G	R	G	K	V	Y	I	R	A	R	A	E	V	E	V	D	A	K	T	G	R	E	T	I	I	V	H	E	I	P	Y	Q	V	N	K	A	R	L	I	E	K	I	A	E	L	V	K	E	K	R	V	E	G	I	S	A	L	R	D	E	S	D	K	D	G	M	R	I	V	I	E	V	K	R	D	A	V	G	E
Query Conservation
Alig confidence																	.	.	.	.	.																																.
Template Conservation																	.	.	.	.	.																																.
Template Sequence		L	G	Q	N	Q	Y	A	V	S	G	E	I	F	V	V	.	.	.	.	.	D	R	N	T	V	E	I	T	E	L	P	V	R	T	W	T	Q	V	Y	K	E	Q	V	L	E	P	M	L	N	G	P	.	A	L	I	S	D	Y	K	E	Y	H	T	D	T	T	V	K	F	V	V	K	M	T	E	E	K	L	A	Q
Template Known Secondary structure				T	T												.	.	.	.	.		T	T									T	T										T									.				S								S	S
Template Predicted Secondary structure																	.	.	.	.	.																																.
Template SS confidence
		918	.	920	.	.	.	.	.	.	.	.	.	930	.	.						.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.		.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.
		315	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.				.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.
Predicted Secondary structure																													.	.	.
Query SS confidence																													.	.	.
Query Sequence		V	V	L	N	N	L	Y	S	Q	T	Q	L	Q	V	S	F	G	I	N	M	V	A	L	H	H	G	Q	.	.	.	P	K	I	M	N	L	K	D	I	I	A	A	F	V	R	H	R	R	E	V	V	T	R	R	T	I	F	E	L	R	K	A	R	D	R	A	H	I	L	E	A	L	A	V	A	L	A	N	I	D
Query Conservation																													.	.	.
Alig confidence																													.	.	.
Template Conservation
Template Sequence		A	E	A	A	G	L	H	K	V	F	K	L	Q	T	T	L	T	C	N	S	M	V	L	F	D	H	M	G	C	L	K	K	Y	E	T	V	Q	D	I	L	K	E	F	F	D	L	R	L	S	Y	Y	G	L	R	K	E	W	L	V	G	M	L	G	A	E	S	T	K	L	N	N	Q	A	R	F	I	L	E	K	I
Template Known Secondary structure					S						T	T															T	T	S						S	S
Template Predicted Secondary structure
Template SS confidence
		996	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.
		392	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.										.	.	.	.	460	.	.
Predicted Secondary structure																																																																		.	.	.	.	.	.	.	.	.
Query SS confidence																																																																		.	.	.	.	.	.	.	.	.
Query Sequence		P	I	I	E	L	I	R	H	A	P	T	P	A	E	A	K	T	A	L	V	A	N	P	W	Q	L	G	N	V	A	A	M	L	E	R	A	G	D	D	A	A	R	P	E	W	L	E	P	E	F	G	V	R	D	G	L	Y	Y	L	T	E	Q	Q	A	.	.	.	.	.	.	.	.	.	Q	A	I	L	D	L	R
Query Conservation																																																																		.	.	.	.	.	.	.	.	.
Alig confidence																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.									.	.	.	.	.	.	.	.	.
Template Conservation																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		Q	G	K	I	T	I	E	N	R	S	K	K	D	L	I	Q	M	L	V	Q	R	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	Y	E	S	D	P	V	K	A	W	K	E	A	Q	G	P	D	F	N	Y	I	L	N	M	S
Template Known Secondary structure			T	S				T	T													T	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.			S																			T	S
Template Predicted Secondary structure																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		1076	.	.	.	1080	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.																																			.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.
		463	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.					.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.
Predicted Secondary structure																																						.	.	.	.
Query SS confidence																																						.	.	.	.
Query Sequence		L	Q	K	L	T	G	L	E	H	E	K	L	L	D	E	Y	K	E	L	L	D	Q	I	A	E	L	L	R	I	L	G	S	A	D	R	L	.	.	.	.	M	E	V	I	R	E	E	L	E	L	V	R	E	Q	F	G	D	K
Query Conservation																																						.	.	.	.
Alig confidence																														.	.							.	.	.	.
Template Conservation																														.	.
Template Sequence		L	W	S	L	T	K	E	K	V	E	E	L	I	K	Q	R	D	A	K	G	R	E	V	N	D	L	K	R	.	.	K	S	P	S	D	L	W	K	E	D	L	A	A	F	V	E	E	L	D	K	V	E	S	Q	E	R	E	D
Template Known Secondary structure		G	G	G	G	S																								.	.	S
Template Predicted Secondary structure																														.	.
Template SS confidence
		1146	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.			.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200	.