Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	L	C	D	R	D	I	E	A	W	L	D	E	G	R	L	S	I	N	P	R	P	P	V	E	R	I	N	G	A	T	V	D	V	R	L	G	N	K	F	R	T	F	R	G	H	T	A	A	F	I	D	L	S	G	P	K	D	E
Secondary structure
SS confidence
Disorder		?	?	?	?																							?																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	S	A	A	L	D	R	V	M	S	D	E	I	V	L	D	E	G	E	A	F	Y	L	H	P	G	E	L	A	L	A	V	T	L	E	S	V	T	L	P	A	D	L	V	G	W	L	D	G	R	S	S	L	A	R	L	G	L	M	V
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	V	T	A	H	R	I	D	P	G	W	S	G	C	I	V	L	E	F	Y	N	S	G	K	L	P	L	A	L	R	P	G	M	L	I	G	A	L	S	F	E	P	L	S	G	P	A	V	R	P	Y	N	R	R	E	D	A	K	Y	R
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.
Sequence		N	Q	Q	G	A	V	A	S	R	I	D	K	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1xs1 chain A Region: 1 - 193 Aligned: 193 Modelled: 193 Confidence: 100.0% Identity: 100% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2qxx chain A Region: 1 - 193 Aligned: 184 Modelled: 193 Confidence: 100.0% Identity: 44% PDB header:hydrolase Chain: A: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase: dutpase from mycobacterium tuberculosis2 in complex with dttp Phyre2 PDB 2qlp chain C Region: 1 - 168 Aligned: 159 Modelled: 168 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase:dutpase from mycobacterium tuberculosis,2 apo form Phyre2 PDB 1pkh chain A Region: 1 - 176 Aligned: 174 Modelled: 176 Confidence: 100.0% Identity: 29% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2r9q chain D Region: 2 - 165 Aligned: 154 Modelled: 164 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: D: PDB Molecule:2'-deoxycytidine 5'-triphosphate deaminase; PDBTitle: crystal structure of 2'-deoxycytidine 5'-triphosphate deaminase from2 agrobacterium tumefaciens Phyre2 PDB 2yzj chain B Region: 2 - 185 Aligned: 158 Modelled: 156 Confidence: 100.0% Identity: 24% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:167aa long hypothetical dutpase; PDBTitle: crystal structure of dctp deaminase from sulfolobus tokodaii Phyre2 PDB 3km3 chain B Region: 2 - 161 Aligned: 146 Modelled: 149 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: crystal structure of eoxycytidine triphosphate deaminase from2 anaplasma phagocytophilum at 2.1a resolution Phyre2 PDB 3mbq chain C Region: 29 - 179 Aligned: 115 Modelled: 115 Confidence: 99.9% Identity: 26% PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form Phyre2 PDB 1dun chain A Region: 20 - 175 Aligned: 113 Modelled: 116 Confidence: 99.9% Identity: 23% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1f7r chain A Region: 31 - 185 Aligned: 113 Modelled: 115 Confidence: 99.9% Identity: 27% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3ehw chain A Region: 29 - 184 Aligned: 115 Modelled: 116 Confidence: 99.9% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:dutp pyrophosphatase; PDBTitle: human dutpase in complex with alpha,beta-imido-dutp and mg2+:2 visualization of the full-length c-termini in all monomers and3 suggestion for an additional metal ion binding site Phyre2 PDB 3tqz chain A Region: 29 - 174 Aligned: 108 Modelled: 108 Confidence: 99.9% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii Phyre2 PDB 1six chain A Region: 29 - 184 Aligned: 115 Modelled: 116 Confidence: 99.9% Identity: 31% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1rnj chain A Region: 29 - 175 Aligned: 109 Modelled: 109 Confidence: 99.9% Identity: 21% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2okd chain B Region: 29 - 174 Aligned: 104 Modelled: 106 Confidence: 99.9% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: high resolution crystal structures of vaccinia virus dutpase Phyre2 PDB 3ca9 chain A Region: 15 - 166 Aligned: 109 Modelled: 112 Confidence: 99.9% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 1euw chain A Region: 29 - 166 Aligned: 100 Modelled: 100 Confidence: 99.9% Identity: 24% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1sjn chain A Region: 29 - 176 Aligned: 108 Modelled: 108 Confidence: 99.9% Identity: 32% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1f7d chain A Region: 29 - 179 Aligned: 103 Modelled: 111 Confidence: 99.9% Identity: 31% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3c3i chain A Region: 29 - 176 Aligned: 106 Modelled: 108 Confidence: 99.9% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 1 d1xs1a_ 2 c2qxxA_ 3 c2qlpC_ 4 d1pkha_ 5 c2r9qD_ 6 c2yzjB_ 7 c3km3B_ 8 c3mbqC_ 9 d1duna_ 10 d1f7ra_ 11 c3ehwA_ 12 c3tqzA_ 13 d1sixa_ 14 d1rnja_ 15 c2okdB_ 16 c3ca9A_ 17 d1euwa_ 18 d1sjna_ 19 d1f7da_ 20 c3c3iA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1xs1a_ 100.0 100 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 2 c2qxxA_ 100.0 44 PDB header:hydrolase Chain: A: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase: dutpase from mycobacterium tuberculosis2 in complex with dttp 3 c2qlpC_ 100.0 45 PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase:dutpase from mycobacterium tuberculosis,2 apo form 4 d1pkha_ 100.0 29 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 5 c2r9qD_ 100.0 25 PDB header:hydrolase Chain: D: PDB Molecule:2'-deoxycytidine 5'-triphosphate deaminase; PDBTitle: crystal structure of 2'-deoxycytidine 5'-triphosphate deaminase from2 agrobacterium tumefaciens 6 c2yzjB_ 100.0 24 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:167aa long hypothetical dutpase; PDBTitle: crystal structure of dctp deaminase from sulfolobus tokodaii 7 c3km3B_ 100.0 29 PDB header:hydrolase Chain: B: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: crystal structure of eoxycytidine triphosphate deaminase from2 anaplasma phagocytophilum at 2.1a resolution 8 c3mbqC_ 99.9 26 PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form 9 d1duna_ 99.9 23 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 10 d1f7ra_ 99.9 27 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 11 c3ehwA_ 99.9 27 PDB header:hydrolase Chain: A: PDB Molecule:dutp pyrophosphatase; PDBTitle: human dutpase in complex with alpha,beta-imido-dutp and mg2+:2 visualization of the full-length c-termini in all monomers and3 suggestion for an additional metal ion binding site 12 c3tqzA_ 99.9 28 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii 13 d1sixa_ 99.9 31 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 14 d1rnja_ 99.9 21 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 15 c2okdB_ 99.9 28 PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: high resolution crystal structures of vaccinia virus dutpase 16 c3ca9A_ 99.9 28 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase 17 d1euwa_ 99.9 24 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 18 d1sjna_ 99.9 32 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 19 d1f7da_ 99.9 31 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 20 c3c3iA_ 99.9 27 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase 21 c3f4fB_ not modelled 99.9 23 PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of dut1p, a dutpase from saccharomyces cerevisiae 22 d1q5uz_ not modelled 99.9 30 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 23 d3ehwa1 not modelled 99.9 29 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 24 d1vyqa1 not modelled 99.9 19 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 25 c3lqwA_ not modelled 99.9 32 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate2 nucleotidohydrolase from entamoeba histolytica 26 c2p9oB_ not modelled 99.9 27 PDB header:hydrolase Chain: B: PDB Molecule:dutp pyrophosphatase-like protein; PDBTitle: structure of dutpase from arabidopsis thaliana 27 c2bazA_ not modelled 99.9 21 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein bsu20020; PDBTitle: structure of yoss, a putative dutpase from bacillus subtilis 28 c3h6xA_ not modelled 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:dutpase; PDBTitle: crystal structure of dutpase from streptococcus mutans 29 c2d4nA_ not modelled 99.9 27 PDB header:hydrolase Chain: A: PDB Molecule:du; PDBTitle: crystal structure of m-pmv dutpase complexed with dupnpp, substrate2 analogue 30 c3ecyA_ not modelled 99.8 24 PDB header:hydrolase Chain: A: PDB Molecule:cg4584-pa, isoform a (bcdna.ld08534); PDBTitle: crystal structural analysis of drosophila melanogaster dutpase 31 d2bsya2 not modelled 99.8 19 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 32 d2bsya1 not modelled 99.8 24 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 33 c2bt1A_ not modelled 99.8 20 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: epstein barr virus dutpase in complex with a,b-imino dutp 34 d1tula_ not modelled 25.3 10 Fold:beta-clip Superfamily:Tlp20, baculovirus telokin-like protein Family:Tlp20, baculovirus telokin-like protein 35 d1vioa2 not modelled 13.7 14 Fold:Alpha-L RNA-binding motif Superfamily:Alpha-L RNA-binding motif Family:Pseudouridine synthase RsuA N-terminal domain 36 d1dm9a_ not modelled 12.4 11 Fold:Alpha-L RNA-binding motif Superfamily:Alpha-L RNA-binding motif Family:Heat shock protein 15 kD 37 c1dm9A_ not modelled 12.4 11 PDB header:structural genomics Chain: A: PDB Molecule:hypothetical 15.5 kd protein in mrca-pcka PDBTitle: heat shock protein 15 kd 38 d1vqop1 not modelled 11.3 21 Fold:Ribosomal protein L19 (L19e) Superfamily:Ribosomal protein L19 (L19e) Family:Ribosomal protein L19 (L19e) 39 d1uwfa1 not modelled 11.1 19 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Bacterial adhesins Family:Pilus subunits 40 c4a1cO_ not modelled 8.6 11 PDB header:ribosome Chain: O: PDB Molecule:rpl19; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 4. 41 c3iz5T_ not modelled 8.3 15 PDB header:ribosome Chain: T: PDB Molecule:60s ribosomal protein l19 (l19e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome 42 d1v54b1 not modelled 7.7 27 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Periplasmic domain of cytochrome c oxidase subunit II 43 d2visc_ not modelled 7.7 17 Fold:Viral protein domain Superfamily:Viral protein domain Family:Influenza hemagglutinin headpiece 44 d2viua_ not modelled 7.2 17 Fold:Viral protein domain Superfamily:Viral protein domain Family:Influenza hemagglutinin headpiece 45 d1mqma_ not modelled 7.1 18 Fold:Viral protein domain Superfamily:Viral protein domain Family:Influenza hemagglutinin headpiece 46 c1ha0A_ not modelled 6.2 17 PDB header:viral protein Chain: A: PDB Molecule:protein (hemagglutinin precursor); PDBTitle: hemagglutinin precursor ha0 47 c2ebbA_ not modelled 6.0 36 PDB header:lyase Chain: A: PDB Molecule:pterin-4-alpha-carbinolamine dehydratase; PDBTitle: crystal structure of pterin-4-alpha-carbinolamine2 dehydratase (pterin carbinolamine dehydratase) from3 geobacillus kaustophilus hta426 48 d2odgc1 not modelled 5.5 25 Fold:LEM/SAP HeH motif Superfamily:LEM domain Family:LEM domain 49 d1zx5a1 not modelled 5.4 13 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:Type I phosphomannose isomerase 50 d2phcb1 not modelled 5.3 27 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:PH0987 C-terminal domain-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0