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Job DescriptionP37388
Confidence100.00%DateThu Jan 5 11:55:35 GMT 2012
Rank2Aligned Residues454
% Identity30%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   5....10.... .....20.........30.........40.........50.........60.........70.........80.
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Query Sequence  LEMKNITKTF. . . GSVKAIDNVCLRLNAGEIVSLCGENGSGKSTLMKVLCGIYPHGSYEGEIIFAGEEIQASHIRDTERK
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLD. . GMVSIDGQDIRTINVRYLREI
Template Known Secondary structure 

SSTTS

S
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SSTTTTTSS

S..TTGGGS
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   388.390.........400.........410.........420.........430.........440.... .....450.........460.....
 
   82.......90.........100.........110.........120.........130........ .140.........150
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Query Sequence  GIAIIHQELALVKELTVLENIFLGNEITHNGIMDYDLMTLRCQKLLAQVSLSISPDT. . . . . . . . . . . RVGDLGLGQQQL
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Template Sequence  . IGVVSQEPVLFAT. TIAENIRYGRE. . . . . . . . . DVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQR
Template Known Secondary structure  .SS



SS.

S.........S

TT
TTSTTGGG


SSSS
SS
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   466...470........ .480......... 490.........500.........510.........520.........530....
 
   151........160.........170.........180.........190.........200.........210.........220.........230
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Query Sequence  VEIAKALNKQVRLLILDEPTASLTEQETSILLDIIRDLQQHGIACIYISHKLNEVKAISDTICVIRDGQHIGTRDAAGMS
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Template Sequence  IAIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELM
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
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   535....540.........550.........560.........570.... .....580......... 590.........600.........610..
 
   231.....
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Query Sequence  EDDIIT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                                
                                 
Template Sequence  REKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSN
Template Known Secondary structure  TST









TTT



SS
STT
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   613......620.........630.........640.........650.........660.........670.........680.........690..
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                
                   
   
   
               
 
  
   
           
Template Sequence  LFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRL
Template Known Secondary structure 

S
S

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   750.........760.........770.........780.........790.........800.........810.........820.........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation     
          
        
 

 
    
                               
 
 
   

     
Template Sequence  AVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTRE
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   830.........840.........850.........860.........870.........880.........890.........900.........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                                
  
                           
  
Template Sequence  QKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSS
Template Known Secondary structure 

TTTT
S
STTTS
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   910.........920.........930.........940.........950.........960.........970.........980.........
 
   237..240.........250.........260.........270.........280.........290.......
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Query Sequence  . . . . . . . . . . . . . . . . . . . MMVGRELTALYPNEPHTTGDEILRIEHLTAWHPVNRHIKRVNDVSFSLKRGEILGIAGLVG
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Template Sequence  FAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSG
Template Known Secondary structure  SSS
SS




SS
S




TTT





S
GGG

SS


SSS
SSS
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   990.........1000.........1010.........1020.........1030.........1040.........1050.........1060.........
 
   298.300.........310.........320.........330.........340.........350.........360.........370.......
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Query Sequence  AGRTETIQCLFGVWPGQWEGKIYIDGKQVDIRNCQQAIAQGIAMVPEDRKRDGIVPVMAVGKNITLAALNKFTGGISQLD
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Template Sequence  CGKSTVVQLLERFYDPM. AGSVFLDGKEIKQLNVQW. LRAQLGIVSQEP. . . . ILFDCSIAENIAYGDNSRVVSY. . . . .
Template Known Secondary structure  TTTTSS

S.SSSS
BTSS
.TTS
SS
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SSBT


SS



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   1070.........1080...... ...1090.........1100.... .....1110...... ...1120.........1130........
 
   378.380.........390.........400.... .....410.........420.........430.........440......
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Query Sequence  DAAEQKCILESIQQLKVKTSSPDLAIG. . . . . . . . . . . RLSGGNQQKAILARCLLLNPRILILDEPTRGIDIGAKYEIYK
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Template Sequence  . . . . . EEIVRAAKEANI. HQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE
Template Known Secondary structure  .....T
.SSTTTGGG
B
STTS
SS


SSS
SSS

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   11391140.........1150 .........1160.........1170.........1180.........1190.........1200.........1210..
 
   447..450.........460.........470.........480.........490..
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Query Sequence  LINQLVQQGIAVIVISSELPEVLGLSDRVLVMHEGKLKANLINHNL
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Template Sequence  ALDKAR. EGRTCIVIAHRLSTIQN. ADLIVVIQNGKVKEHGTHQQL
Template Known Secondary structure  S.SSS

S
TTGGGS.
STB
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   1213..... .1220.........1230..... ....1240.........1250......
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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