Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	L	F	T	T	L	L	V	L	I	F	E	R	L	F	K	L	G	E	H	W	Q	L	D	H	R	L	E	A	F	F	R	R	V	K	H	F	S	L	G	R	T	L	G	M	T	I	I	A	M	G	V	T	F	L	L	L	R	A
Secondary structure
SS confidence
Disorder		?																																		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	Q	G	V	L	F	N	V	P	T	L	L	V	W	L	L	I	G	L	L	C	I	G	A	G	K	V	R	L	H	Y	H	A	Y	L	T	A	A	S	R	N	D	S	H	A	R	A	T	M	A	G	E	L	T	M	I	H	G	V	P
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	C	D	E	R	E	Y	L	R	E	L	Q	N	A	L	L	W	I	N	F	R	F	Y	L	A	P	L	F	W	L	I	V	G	G	T	W	G	P	V	T	L	M	G	Y	A	F	L	R	A	W	Q	Y	W	L	A	R	Y	Q	T
Secondary structure
SS confidence
Disorder		?	?	?	?																																																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	H	H	R	L	Q	S	G	I	D	A	V	L	H	V	L	D	W	V	P	V	R	L	A	G	V	V	Y	A	L	I	G	H	G	E	K	A	L	P	A	W	F	A	S	L	G	D	F	H	T	S	Q	Y	Q	V	L	T	R	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?																																											?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.
Sequence		Q	F	S	L	A	R	E	P	H	V	D	K	V	E	T	P	K	A	A	V	S	M	A	K	K	T	S	F	V	V	V	V	V	I	A	L	L	T	I	Y	G	A	L	V
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?																																?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3f40 chain A Region: 88 - 110 Aligned: 23 Modelled: 23 Confidence: 23.0% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized ntf2-like protein; PDBTitle: crystal structure of ntf2-like protein of unknown function2 (yp_677363.1) from cytophaga hutchinsonii atcc 33406 at3 1.27 a resolution Phyre2 PDB 1sr2 chain A Region: 81 - 113 Aligned: 33 Modelled: 33 Confidence: 19.7% Identity: 3% Fold: Four-helical up-and-down bundle Superfamily: Histidine-containing phosphotransfer domain, HPT domain Family: Sensor-like histidine kinase YojN, C-terminal domain Phyre2 PDB 3na8 chain A Region: 89 - 134 Aligned: 46 Modelled: 46 Confidence: 15.8% Identity: 4% PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase; PDBTitle: crystal structure of a putative dihydrodipicolinate synthetase from2 pseudomonas aeruginosa Phyre2 PDB 1iqp chain A domain 1 Region: 89 - 136 Aligned: 44 Modelled: 48 Confidence: 15.6% Identity: 11% Fold: post-AAA+ oligomerization domain-like Superfamily: post-AAA+ oligomerization domain-like Family: DNA polymerase III clamp loader subunits, C-terminal domain Phyre2 PDB 3ff2 chain A Region: 89 - 109 Aligned: 21 Modelled: 21 Confidence: 14.7% Identity: 14% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized cystatin fold protein (yp_497570.1) from PDBTitle: crystal structure of an uncharacterized cystatin fold protein2 (saro_2299) from novosphingobium aromaticivorans dsm at 1.90 a3 resolution Phyre2 PDB 1wn0 chain A domain 1 Region: 81 - 113 Aligned: 33 Modelled: 33 Confidence: 14.1% Identity: 12% Fold: Four-helical up-and-down bundle Superfamily: Histidine-containing phosphotransfer domain, HPT domain Family: Phosphorelay protein-like Phyre2 PDB 3h5d chain D Region: 87 - 134 Aligned: 48 Modelled: 48 Confidence: 13.2% Identity: 13% PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: dihydrodipicolinate synthase from drug-resistant streptococcus2 pneumoniae Phyre2 PDB 256b chain A Region: 83 - 113 Aligned: 31 Modelled: 31 Confidence: 13.2% Identity: 16% Fold: Four-helical up-and-down bundle Superfamily: Cytochromes Family: Cytochrome b562 Phyre2 PDB 3soy chain A Region: 85 - 105 Aligned: 21 Modelled: 21 Confidence: 12.8% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:ntf2-like superfamily protein; PDBTitle: nuclear transport factor 2 (ntf2-like) superfamily protein from2 salmonella enterica subsp. enterica serovar typhimurium str. lt2 Phyre2 PDB 1sxj chain C domain 1 Region: 88 - 136 Aligned: 45 Modelled: 49 Confidence: 12.4% Identity: 11% Fold: post-AAA+ oligomerization domain-like Superfamily: post-AAA+ oligomerization domain-like Family: DNA polymerase III clamp loader subunits, C-terminal domain Phyre2 PDB 3si9 chain B Region: 89 - 134 Aligned: 46 Modelled: 46 Confidence: 12.1% Identity: 7% PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from bartonella2 henselae Phyre2 PDB 3eb2 chain A Region: 87 - 134 Aligned: 48 Modelled: 48 Confidence: 11.9% Identity: 6% PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 rhodopseudomonas palustris at 2.0a resolution Phyre2 PDB 3op1 chain A Region: 90 - 110 Aligned: 21 Modelled: 21 Confidence: 11.4% Identity: 5% PDB header:transferase Chain: A: PDB Molecule:macrolide-efflux protein; PDBTitle: crystal structure of macrolide-efflux protein sp_1110 from2 streptococcus pneumoniae Phyre2 PDB 1yvi chain A domain 1 Region: 81 - 113 Aligned: 33 Modelled: 33 Confidence: 11.4% Identity: 12% Fold: Four-helical up-and-down bundle Superfamily: Histidine-containing phosphotransfer domain, HPT domain Family: Phosphorelay protein-like Phyre2 PDB 2x0k chain B Region: 90 - 112 Aligned: 23 Modelled: 23 Confidence: 11.0% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribf; PDBTitle: crystal structure of modular fad synthetase from2 corynebacterium ammoniagenes Phyre2 PDB 2gqb chain A domain 1 Region: 86 - 140 Aligned: 55 Modelled: 55 Confidence: 10.9% Identity: 9% Fold: RPA2825-like Superfamily: RPA2825-like Family: RPA2825-like Phyre2 PDB 1t6z chain B Region: 90 - 110 Aligned: 21 Modelled: 21 Confidence: 10.8% Identity: 0% PDB header:transferase Chain: B: PDB Molecule:riboflavin kinase/fmn adenylyltransferase; PDBTitle: crystal structure of riboflavin bound tm379 Phyre2 PDB 1o5k chain A Region: 89 - 134 Aligned: 46 Modelled: 46 Confidence: 10.7% Identity: 4% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3ixz chain B Region: 143 - 181 Aligned: 36 Modelled: 39 Confidence: 10.6% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:potassium-transporting atpase subunit beta; PDBTitle: pig gastric h+/k+-atpase complexed with aluminium fluoride Phyre2 PDB 3bi8 chain A Region: 89 - 134 Aligned: 46 Modelled: 46 Confidence: 10.5% Identity: 4% PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: structure of dihydrodipicolinate synthase from clostridium2 botulinum Phyre2 1 c3f40A_ 2 d1sr2a_ 3 c3na8A_ 4 d1iqpa1 5 c3ff2A_ 6 d1wn0a1 7 c3h5dD_ 8 d256ba_ 9 c3soyA_ 10 d1sxjc1 11 c3si9B_ 12 c3eb2A_ 13 c3op1A_ 14 d1yvia1 15 c2x0kB_ 16 d2gqba1 17 c1t6zB_ 18 d1o5ka_ 19 c3ixzB_ 20 c3bi8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3f40A_ 23.0 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized ntf2-like protein; PDBTitle: crystal structure of ntf2-like protein of unknown function2 (yp_677363.1) from cytophaga hutchinsonii atcc 33406 at3 1.27 a resolution 2 d1sr2a_ 19.7 3 Fold:Four-helical up-and-down bundle Superfamily:Histidine-containing phosphotransfer domain, HPT domain Family:Sensor-like histidine kinase YojN, C-terminal domain 3 c3na8A_ 15.8 4 PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase; PDBTitle: crystal structure of a putative dihydrodipicolinate synthetase from2 pseudomonas aeruginosa 4 d1iqpa1 15.6 11 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:DNA polymerase III clamp loader subunits, C-terminal domain 5 c3ff2A_ 14.7 14 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized cystatin fold protein (yp_497570.1) from PDBTitle: crystal structure of an uncharacterized cystatin fold protein2 (saro_2299) from novosphingobium aromaticivorans dsm at 1.90 a3 resolution 6 d1wn0a1 14.1 12 Fold:Four-helical up-and-down bundle Superfamily:Histidine-containing phosphotransfer domain, HPT domain Family:Phosphorelay protein-like 7 c3h5dD_ 13.2 13 PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: dihydrodipicolinate synthase from drug-resistant streptococcus2 pneumoniae 8 d256ba_ 13.2 16 Fold:Four-helical up-and-down bundle Superfamily:Cytochromes Family:Cytochrome b562 9 c3soyA_ 12.8 14 PDB header:membrane protein Chain: A: PDB Molecule:ntf2-like superfamily protein; PDBTitle: nuclear transport factor 2 (ntf2-like) superfamily protein from2 salmonella enterica subsp. enterica serovar typhimurium str. lt2 10 d1sxjc1 12.4 11 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:DNA polymerase III clamp loader subunits, C-terminal domain 11 c3si9B_ 12.1 7 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from bartonella2 henselae 12 c3eb2A_ 11.9 6 PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 rhodopseudomonas palustris at 2.0a resolution 13 c3op1A_ 11.4 5 PDB header:transferase Chain: A: PDB Molecule:macrolide-efflux protein; PDBTitle: crystal structure of macrolide-efflux protein sp_1110 from2 streptococcus pneumoniae 14 d1yvia1 11.4 12 Fold:Four-helical up-and-down bundle Superfamily:Histidine-containing phosphotransfer domain, HPT domain Family:Phosphorelay protein-like 15 c2x0kB_ 11.0 13 PDB header:transferase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribf; PDBTitle: crystal structure of modular fad synthetase from2 corynebacterium ammoniagenes 16 d2gqba1 10.9 9 Fold:RPA2825-like Superfamily:RPA2825-like Family:RPA2825-like 17 c1t6zB_ 10.8 0 PDB header:transferase Chain: B: PDB Molecule:riboflavin kinase/fmn adenylyltransferase; PDBTitle: crystal structure of riboflavin bound tm379 18 d1o5ka_ 10.7 4 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 19 c3ixzB_ 10.6 19 PDB header:hydrolase Chain: B: PDB Molecule:potassium-transporting atpase subunit beta; PDBTitle: pig gastric h+/k+-atpase complexed with aluminium fluoride 20 c3bi8A_ 10.5 4 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: structure of dihydrodipicolinate synthase from clostridium2 botulinum 21 d2a6na1 not modelled 10.5 6 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 22 c3noeA_ not modelled 10.1 15 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa 23 d1xkya1 not modelled 9.7 4 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 24 c3ehcA_ not modelled 9.4 18 PDB header:unknown function Chain: A: PDB Molecule:snoal-like polyketide cyclase; PDBTitle: crystal structure of a snoal-like polyketide cyclase (atu3018) from2 agrobacterium tumefaciens str. c58 at 2.12 a resolution 25 c2vc6A_ not modelled 9.0 11 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: structure of mosa from s. meliloti with pyruvate bound 26 c3myfB_ not modelled 9.0 15 PDB header:transferase Chain: B: PDB Molecule:sensor protein; PDBTitle: the crystal structure of the hpt domain from the hpt sensor hybrid2 histidine kinase from shewanella to 1.80a 27 c2ehhE_ not modelled 8.8 11 PDB header:lyase Chain: E: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 aquifex aeolicus 28 c3fluD_ not modelled 8.7 11 PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from the pathogen2 neisseria meningitidis 29 d2k54a1 not modelled 8.5 21 Fold:Cystatin-like Superfamily:NTF2-like Family:Atu0742-like 30 c3b8eB_ not modelled 8.2 14 PDB header:hydrolase/transport protein Chain: B: PDB Molecule:sodium/potassium-transporting atpase subunit PDBTitle: crystal structure of the sodium-potassium pump 31 d1hynp_ not modelled 8.2 23 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:Anion transport protein, cytoplasmic domain 32 c1hynQ_ not modelled 8.1 23 PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein 33 c3f8hA_ not modelled 7.4 12 PDB header:unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (tm1040_3560) from2 silicibacter sp. tm1040 at 2.00 a resolution 34 d1hw1a2 not modelled 7.4 13 Fold:GntR ligand-binding domain-like Superfamily:GntR ligand-binding domain-like Family:GntR ligand-binding domain-like 35 c3g0sA_ not modelled 7.3 9 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: dihydrodipicolinate synthase from salmonella typhimurium lt2 36 d2gxfa1 not modelled 6.9 14 Fold:Cystatin-like Superfamily:NTF2-like Family:YybH-like 37 c3pueA_ not modelled 6.9 9 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of the complex of dhydrodipicolinate synthase from2 acinetobacter baumannii with lysine at 2.6a resolution 38 c3s5oA_ not modelled 6.3 4 PDB header:lyase Chain: A: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase, mitochondrial; PDBTitle: crystal structure of human 4-hydroxy-2-oxoglutarate aldolase bound to2 pyruvate 39 c3mv2A_ not modelled 6.1 19 PDB header:protein transport Chain: A: PDB Molecule:coatomer subunit alpha; PDBTitle: crystal structure of a-cop in complex with e-cop 40 c3lerA_ not modelled 5.5 11 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 campylobacter jejuni subsp. jejuni nctc 11168 41 d1y6da_ not modelled 5.4 5 Fold:Four-helical up-and-down bundle Superfamily:Histidine-containing phosphotransfer domain, HPT domain Family:Phosphorelay protein luxU 42 c3k1sE_ not modelled 5.3 14 PDB header:transferase Chain: E: PDB Molecule:pts system, cellobiose-specific iia component; PDBTitle: crystal structure of the pts cellobiose specific enzyme iia2 from bacillus anthracis 43 c2ksnA_ not modelled 5.2 17 PDB header:signaling protein Chain: A: PDB Molecule:ubiquitin domain-containing protein 2; PDBTitle: solution structure of the n-terminal domain of dc-ubp/ubtd2 44 c2pcqA_ not modelled 5.2 16 PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthase; PDBTitle: crystal structure of putative dihydrodipicolinate synthase (ttha0737)2 from thermus thermophilus hb8 45 d3dmca1 not modelled 5.1 0 Fold:Cystatin-like Superfamily:NTF2-like Family:PhzA/PhzB-like 46 c3sn6R_ not modelled 5.1 6 PDB header:signaling protein/hydrolase Chain: R: PDB Molecule:lysozyme, beta-2 adrenergic receptor; PDBTitle: crystal structure of the beta2 adrenergic receptor-gs protein complex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0