Return to main results Retrieve Phyre Job Id

Job DescriptionP0A9W3
Confidence100.00%DateThu Jan 5 11:11:33 GMT 2012
Rank5Aligned Residues475
% Identity32%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   6...10....... ..20.........30.........40.........50.........60.........70 ..
Predicted Secondary structure 


..

























...........
Query SS confidence 











. .




















































. . . . . . . . . . .

Query Sequence  YTMHRVGKVVPP. . KRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEGEARPQPDIK. . . . . . . . . . . IG
Query Conservation 
    
      ..    
  


 
  

  



 








  
 
   
  
 
       ...........
 
Alig confidence 











..




















































...........

Template Conservation 
                 
         
    
 
  







  
 
      
 
   
                
Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIG
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
Template Predicted Secondary structure 








































Template SS confidence 















































































   388.390.........400.........410.........420.........430.........440.........450.........460.......
 
   73......80.........90.........100.........110.........120.........130.........140.........150..
Predicted Secondary structure 



















Query SS confidence 















































































Query Sequence  YLPQEPQLNPEHTVRESIEEAVSEVVNALKRLDEVYALYADPDADFDKLAAEQGRLEEIIQAHDGHNLNVQLERAADALR
Query Conservation   
 
        

   
                                     
                   
  
 
Alig confidence 










.















..........................................









Template Conservation     
   
   .
   

          ..........................................          
Template Sequence  VVSQEPVLFAT. TIAENIRYGREDVTMD. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EIEKAVKEAN
Template Known Secondary structure  SS



SS.

SS

..........................................TT
Template Predicted Secondary structure 










.





..........................................

Template SS confidence 















































































   468.470........ .480.........490.... .....500....
 
   153.. ... .160.........170.........180.........190.........200........ .210........
Predicted Secondary structure 


.


...........














..





Query SS confidence 


.


. . . . . . . . . . .

















































. .









Query Sequence  LPD. WDA. . . . . . . . . . . KIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDF. . EGTVVAITHD
Query Conservation 
  .
  ...........    








 

 

   
 







  

      
   
   ..  


 


 
Alig confidence 


.


...........

















































..









Template Conservation                        

 

  
  



      
  


    

      
           
 
   
 
Template Sequence  AYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHR
Template Known Secondary structure 
TTSTTGGG


SSSS
SS


SBTT
SS
TTSS
S
Template Predicted Secondary structure 



































Template SS confidence 















































































   505....510.........520.........530.........540.........550.........560.........570.........580....
 
   219220.........230.........240.........250.........260.........270...
Predicted Secondary structure 






.........................
Query SS confidence 






















































. . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  RYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKDQRLAQEASQEAARRKSIEKEL. . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation     
    
 
  
  
 
    
                               .........................
Alig confidence 




.














.
































.........................
Template Conservation       .  
 
     
    . 
    
                                               
   
Template Sequence  LSTVR. NADVIAGFDGGVIVE. QGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGG
Template Known Secondary structure  T.T
S
SSS



.
TST









TTT



Template Predicted Secondary structure  .





.















Template SS confidence 















































































   585.... 590.........600.... .....610.........620.........630.........640.........650.........660..
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                              
                   
   
   
       
Template Sequence  LQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSW
Template Known Secondary structure  SS
STT

Template Predicted Secondary structure 











Template SS confidence 















































































   720.........730.........740.........750.........760.........770.........780.........790.........
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation          
 
  
   
           
   
          
        
 

 
    
                
Template Sequence  FDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA
Template Known Secondary structure  S
S

SS
STT
Template Predicted Secondary structure 






Template SS confidence 















































































   800.........810.........820.........830.........840.........850.........860.........870.........
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                 
 
 
   

                                                   
  
Template Sequence  LKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYL
Template Known Secondary structure  TT
TTTTT
SS

Template Predicted Secondary structure 
Template SS confidence 















































































   880.........890.........900.........910.........920.........930.........940.........950.........
 
   274.....280.........290.........300.........310.........320.........330..
Predicted Secondary structure  .....................





































Query SS confidence  . . . . . . . . . . . . . . . . . . . . .


























































Query Sequence  . . . . . . . . . . . . . . . . . . . . . EWVRQGTKGRQSKGKARLARFEELNSTEYQKRNETNELFIPPGPRLGDKVLEVSNLRKS
Query Conservation  .....................                 
                                
        
Alig confidence  .....................


























































Template Conservation                             
            
  

   
                    
 
    
   
Template Sequence  VTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFN
Template Known Secondary structure  TTTT
S
STTTSSSS
SS




SS
S




TTT




Template Predicted Secondary structure 



























Template SS confidence 















































































   960.........970.........980.........990.........1000.........1010.........1020.........1030.........
 
   333 ......340.........350.........360.........370.........380.... .....390........
Predicted Secondary structure 
...




















...........


Query SS confidence 
. . .


















































. . . . . . . . . . .













Query Sequence  Y. . . GDRLLIDDLSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGTITLGE. . . . . . . . . . . TVKLASVDQFRDSM
Query Conservation 
...     
  
   
  

   
 
 








  
 
      
 
    ...........   
    
    
Alig confidence 
...


















































...........










..
Template Conservation 
       

  

  
  

 




 








  
 
      
 
 
 
  
       

  
  


  .. 
Template Sequence  YPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEP. . I
Template Known Secondary structure 
S
GGG

SS


SSS
SSSTTTTSS

SSSSS
BTSS
TTS
SS
..
Template Predicted Secondary structure 

































..
Template SS confidence 















































































   1040.........1050.........1060.........1070.........1080.........1090.........1100.........1110...... .
 
   399400.........410.........420.........430.........440.. .......450.........460........
Predicted Secondary structure 















..........





Query SS confidence 











































. . . . . . . . . .

























Query Sequence  DNSKTVWEEVSGGLDIMKIGNTEMPSRAYVGRFNFKGVDQGKRV. . . . . . . . . . GELSGGERGRLHLAKLLQVGGNMLLL
Query Conservation      

   
                   
    
         ..........  




 


 

  
   
 



Alig confidence 






















..


















..........

























Template Conservation 

  





             ..
   
    
   
  
  


  
   
  

 





 





    



Template Sequence  LFDCSIAENIAYGDNSRVVSYEE. . IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLL
Template Known Secondary structure 

SSBT


SS



..T
SSTTTGGG
B
STTS
SS


SS
Template Predicted Secondary structure 












..






















Template SS confidence 















































































   1118.1120.........1130.........1140 .........1150.........1160.........1170.........1180.........1190.....
 
   469470.........480.........490 .........500.........510.........520.........530..
Predicted Secondary structure 







..











Query SS confidence 





















. .









































Query Sequence  DEPTNDLDIETLRALENALLEF. . PGCAMVISHDRWFLDRIATHILDYQDEGKVEFFEGNFTEYEE
Query Conservation 



 


      
   
   ..  


 



        
 
  
   
 
    
       
Alig confidence 





















..














.









.





.







Template Conservation 




 

      
   
       


 


      .  
 
 

  .
 
 
 .
    
  
Template Sequence  DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ. NADLIVVIQN. GKVKEH. GTHQQLLA
Template Known Secondary structure  S
SSS

SSSS

S
TTGGG.S
ST.B.
Template Predicted Secondary structure 












.


.
.

Template SS confidence 

































































   1196...1200.........1210.........1220.........1230.... .....1240.... .....1250 ........
 
Download:Text version FASTA pairwise alignment 3D Model in PDB format

View in Jmol

Send structure to FirstGlance for more viewing options


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
Disclaimer
Terms and Conditions