Job Description P77265 Confidence 100.00% Date Thu Jan 5 12:26:59 GMT 2012 Rank 4 Aligned Residues 583 % Identity 25% Template c3g5uB_ PDB info PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Resolution 3.80 Å

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		4	.	.	.	.	.	10	.	.	.	.		.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.																				.	.	.	.	.	60	.	.	.
Predicted Secondary structure													.																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence													.																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		F	A	Q	L	S	W	Y	F	R	R	E	.	W	R	R	Y	L	G	A	V	A	L	L	V	I	I	A	M	L	Q	L	V	P	P	K	V	V	G	I	V	V	D	G	V	T	E	Q	H	F	T	T	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	Q	I	L	M	W	I	A	T	M
Query Conservation													.																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence													.																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		V	L	T	M	F	R	Y	A	G	W	L	D	R	L	Y	M	L	V	G	T	L	A	A	I	I	H	G	V	A	L	P	L	M	M	L	I	F	G	D	M	T	D	S	F	A	S	V	G	N	V	S	K	N	S	T	N	M	S	E	A	D	K	R	A	M	F	A	K	L	E	E	E	M	T	T	Y	A	Y	Y	Y
Template Known Secondary structure		T					T																																																	S	S		S
Template Predicted Secondary structure
Template SS confidence
		35	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.
		64	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		V	L	I	A	V	V	V	Y	L	L	R	Y	V	W	R	V	L	L	F	G	A	S	Y	Q	L	A	V	E	L	R	E	D	Y	Y	R	Q	L	S	R	Q	H	P	E	F	Y	L	R	H	R	T	G	D	L	M	A	R	A	T	N	D	V	D	R	V	V	F	A	A	G	E	G	V	L	T	L	V	D	S	L	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		T	G	I	G	A	G	V	L	I	V	A	Y	I	Q	V	S	F	W	C	L	A	A	G	R	Q	I	H	K	I	R	Q	K	F	F	H	A	I	M	N	Q	E	I	G	W	F	D	V	H	D	V	G	E	L	N	T	R	L	T	D	D	V	S	K	I	N	E	G	I	G	D	K	I	G	M	F	F	Q	A	M	A
Template Known Secondary structure																																										T	T					S	S		S
Template Predicted Secondary structure
Template SS confidence
		115	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.
		144	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		M	G	C	A	V	L	I	M	M	S	T	Q	I	S	W	Q	L	T	L	F	S	L	L	P	M	P	V	M	A	I	M	I	K	R	N	G	D	A	L	H	E	R	F	K	L	A	Q	A	A	F	S	S	L	N	D	R	T	Q	E	S	L	T	S	I	R	M	I	K	A	F	G	L	E	D	R	Q	S	A	L	F
Query Conservation
Alig confidence										.
Template Conservation										.
Template Sequence		T	F	F	G	G	F	I	I	.	G	F	T	R	G	W	K	L	T	L	V	I	L	A	I	S	P	V	L	G	L	S	A	G	I	W	A	K	I	L	S	S	F	T	D	K	E	L	H	A	Y	A	K	A	G	A	V	A	E	E	V	L	A	A	I	R	T	V	I	A	F	G	G	Q	K	K	E	L	E	R	Y
Template Known Secondary structure										.				T	T	T	T	S																																							T	T	T											T	T					S
Template Predicted Secondary structure										.
Template SS confidence
		195	.	.	.	.	200	.	.		.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.
		224	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	A	D	A	E	D	T	G	K	K	N	M	R	V	A	R	I	D	A	R	F	D	P	T	I	Y	I	A	I	G	M	A	N	L	L	A	I	G	G	G	S	W	M	V	V	Q	G	S	L	T	L	G	Q	L	T	S	F	M	M	Y	L	G	L	M	I	W	P	M	L	A	L	A	W	M	F	N	I	V	E	R
Query Conservation
Alig confidence
Template Conservation
Template Sequence		N	N	N	L	E	E	A	K	R	L	G	I	K	K	A	I	T	A	N	I	S	M	G	A	A	F	L	L	I	Y	A	S	Y	A	L	A	F	W	Y	G	T	S	L	V	I	S	K	E	Y	S	I	G	Q	V	L	T	V	F	F	S	V	L	I	G	A	F	S	V	G	Q	A	S	P	N	I	E	A	F	A	N
Template Known Secondary structure														T	T	T																																S	S	S		S	S
Template Predicted Secondary structure
Template SS confidence
		274	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.
		304	.	.	.	.	.	310	.	.	.	.	.	.	.	.				.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.		.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																	.	.	.																											.
Query SS confidence																	.	.	.																											.
Query Sequence		G	S	A	A	Y	S	R	I	R	A	M	L	A	E	A	.	.	.	P	V	V	N	D	G	S	E	P	V	P	E	G	R	G	E	L	D	V	N	I	H	Q	F	T	Y	.	P	Q	T	D	H	P	A	L	E	N	V	N	F	A	L	K	P	G	Q	M	L	G	I	C	G	P	T	G	S	G	K	S	T	L	L
Query Conservation																	.	.	.																											.
Alig confidence																	.	.	.																											.
Template Conservation
Template Sequence		A	R	G	A	A	Y	E	V	F	K	I	I	D	N	K	P	S	I	D	S	F	S	K	S	G	H	K	P	D	N	I	Q	G	N	L	E	F	K	N	I	H	F	S	Y	P	S	R	K	E	V	Q	I	L	K	G	L	N	L	K	V	K	S	G	Q	T	V	A	L	V	G	N	S	G	C	G	K	S	T	T	V
Template Known Secondary structure												T	T	S						S	S			S						T	T		S													S	S	T	T	S			S										T	T									S	S	T	T
Template Predicted Secondary structure
Template SS confidence
		354	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.
		380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	L	I	Q	R	H	F	D	V	S	E	G	D	I	R	F	H	D	I	P	L	T	K	L	Q	L	D	S	W	R	S	R	L	A	V	V	S	Q	T	P	F	L	F	S	D	T	V	A	N	N	I	A	L	G	C	P	N	A	T	Q	Q	E	I	E	H	V	A	R	L	A	S	V	H	D	D	I	L	R	L	P
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Q	L	M	Q	R	L	Y	D	P	L	D	G	M	V	S	I	D	G	Q	D	I	R	T	I	N	V	R	Y	L	R	E	I	I	G	V	V	S	Q	E	P	V	L	F	A	T	T	I	A	E	N	I	R	Y	G	R	E	D	V	T	M	D	E	I	E	K	A	V	K	E	A	N	A	Y	D	F	I	M	K	L	P
Template Known Secondary structure				T	T	T	S	S			S							T	T			G	G	G	S														S	S					S	S											S	S													T	T		T	T					S	T
Template Predicted Secondary structure
Template SS confidence
		434	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.
		460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	G	Y	D	T	E	V	G	E	R	G	V	M	L	S	G	G	Q	K	Q	R	I	S	I	A	R	A	L	L	V	N	A	E	I	L	I	L	D	D	A	L	S	A	V	D	G	R	T	E	H	Q	I	L	H	N	L	R	Q	W	G	Q	G	R	T	V	I	I	S	A	H	R	L	S	A	L	T	E	A	S	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		H	Q	F	D	T	L	V	G	E	R	G	A	Q	L	S	G	G	Q	K	Q	R	I	A	I	A	R	A	L	V	R	N	P	K	I	L	L	L	D	E	A	T	S	A	L	D	T	E	S	E	A	V	V	Q	A	A	L	D	K	A	R	E	G	R	T	T	I	V	I	A	H	R	L	S	T	V	R	N	A	D	V
Template Known Secondary structure		T	G	G	G				S	S	S	S		S	S																			S						B	T	T		S	S																T	T	S	S							S						T	T		S
Template Predicted Secondary structure
Template SS confidence
		514	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.
		540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	I	V	M	Q	H	G	H	I	A	Q	R	G	N	H	D	V	L	A	Q	Q	S	G	W	Y	R	D	M	Y	R	Y	Q	Q	L	E	A	A	L	D	D	A	P	E	N	R	E	E	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		I	A	G	F	D	G	G	V	I	V	E	Q	G	N	H	D	E	L	M	R	E	K	G	I	Y	F	K	L	V	M	T	Q	T	L	D	E	D	V	P	P	A	S	F	W	R	I	L	K
Template Known Secondary structure						S	S	S															T	S									T											T	T
Template Predicted Secondary structure
Template SS confidence
		594	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.