Job Description P31826 Confidence 100.00% Date Thu Jan 5 11:48:49 GMT 2012 Rank 3 Aligned Residues 520 % Identity 15% Template c3g5uB_ PDB info PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Resolution 3.80 Å

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		17	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.																						.	70	.	.	.	.	.
Predicted Secondary structure																																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		C	L	L	K	P	F	W	L	R	K	N	N	K	T	S	V	L	L	I	I	I	I	L	A	M	I	L	G	V	V	K	I	Q	V	W	L	N	D	W	N	N	D	F	F	N	A	L	S	Q	K	E	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	K	L	W	Q	L	V
Query Conservation																																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence						.																			.																													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation						.																			.
Template Sequence		S	V	L	T	.	M	F	R	Y	A	G	W	L	D	R	L	Y	M	L	V	G	T	L	.	A	A	I	I	H	G	V	A	L	P	L	M	M	L	I	F	G	D	M	T	D	S	F	A	S	V	G	N	V	S	K	N	S	T	N	M	S	E	A	D	K	R	A	M	F	A	K	L	E	E	E	M	T	T	Y	A
Template Known Secondary structure		T	T			.			T																.																																		S	S		S
Template Predicted Secondary structure						.																			.
Template SS confidence
		34	.	.	.		.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.		.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.
		76	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	W	F	P	A	L	L	G	I	F	V	L	I	S	V	N	K	T	W	L	I	K	L	L	T	I	R	W	R	E	W	L	T	D	Y	Y	L	N	R	W	F	A	D	K	N	Y	Y	F	T	Q	I	Y	G	E	H	K	N	T	D	N	P	D	Q	R	I	A	E	D	I	L	L	L	I	S	K	T	L	S	L	S
Query Conservation
Alig confidence																																																				.	.	.	.	.
Template Conservation																																																				.	.	.	.	.
Template Sequence		Y	Y	Y	T	G	I	G	A	G	V	L	I	V	A	Y	I	Q	V	S	F	W	C	L	A	A	G	R	Q	I	H	K	I	R	Q	K	F	F	H	A	I	M	N	Q	E	I	G	W	F	D	V	.	.	.	.	.	H	D	V	G	E	L	N	T	R	L	T	D	D	V	S	K	I	N	E	G	I	G	D	K	I
Template Known Secondary structure																																													T	T					S	.	.	.	.	.	S		S
Template Predicted Secondary structure																																																				.	.	.	.	.
Template SS confidence
		112	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.						.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.
		156	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	G	F	I	Q	S	L	S	M	L	I	T	F	T	V	I	L	W	E	S	A	G	T	L	S	F	T	V	G	G	T	E	W	N	I	Q	G	Y	M	V	Y	T	V	V	L	I	V	I	G	G	T	L	F	T	H	K	V	G	K	R	I	R	P	L	N	V	E	K	Q	R	S	E	A	T	F	R	T	N	L	V
Query Conservation
Alig confidence																													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		G	M	F	F	Q	A	M	A	T	F	F	G	G	F	I	I	G	F	T	R	G	W	K	L	T	L	V	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	I	L	A	I	S	P	V	L	G	L	S	A	G	I	W	A	K	I	L	S	S	F	T	D	K	E	L	H	A	Y	A	K	A	G	A	V	A	E
Template Known Secondary structure																					T	T	T	T	S				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																				T	T	T
Template Predicted Secondary structure																													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		187	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.																.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.
		236	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	H	N	K	Q	A	E	L	I	A	L	S	N	A	E	S	L	Q	R	Q	E	L	S	D	N	F	H	T	I	K	E	N	W	H	R	L	M	N	R	Q	R	W	L	D	Y	W	Q	N	I	Y	S	R	S	L	S	V	L	P	Y	F	L	L	L	P	Q	F	I	S	G	Q	I	N	L	G	G	L	M	K	S	R
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	V	L	A	A	I	R	T	V	I	A	F	G	G	Q	K	K	E	L	E	R	Y	N	N	N	L	E	E	A	K	R	L	G	I	K	K	A	I	T	A	N	I	S	M	G	A	A	F	L	L	I	Y	A	S	Y	A	L	A	F	W	Y	G	T	S	L	V	I	S	K	E	Y	S	I	G	Q	V	L	T	V	F
Template Known Secondary structure												T	T					S																		T	T	T																																S	S	S		S	S
Template Predicted Secondary structure
Template SS confidence
		252	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.
		316	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.						.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.			.	380	.	.	.	.	.	.	.	.
Predicted Secondary structure																																							.	.	.	.	.																											.	.
Query SS confidence																																							.	.	.	.	.																											.	.
Query Sequence		Q	A	F	M	L	V	S	N	N	L	S	W	F	I	Y	K	Y	D	E	L	A	E	L	A	A	V	I	D	R	L	Y	E	F	H	Q	L	T	.	.	.	.	.	E	Q	R	P	T	N	K	P	K	N	C	Q	H	A	V	Q	V	A	D	A	S	I	R	T	P	D	.	.	N	K	I	I	L	E	N	L	N	F
Query Conservation																																							.	.	.	.	.																											.	.
Alig confidence																																							.	.	.	.	.																											.	.
Template Conservation
Template Sequence		F	S	V	L	I	G	A	F	S	V	G	Q	A	S	P	N	I	E	A	F	A	N	A	R	G	A	A	Y	E	V	F	K	I	I	D	N	K	P	S	I	D	S	F	S	K	S	G	H	K	P	D	N	I	Q	G	N	L	E	F	K	N	I	H	F	S	Y	P	S	R	K	E	V	Q	I	L	K	G	L	N	L
Template Known Secondary structure																																		T	T	S						S	S			S						T	T		S													S	S	T	T	S			S
Template Predicted Secondary structure
Template SS confidence
		332	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.
		389	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.														430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Predicted Secondary structure																																											.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																											.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		H	V	S	P	G	K	W	L	L	L	K	G	Y	S	G	A	G	K	T	T	L	L	K	T	L	S	H	C	W	P	W	F	K	G	D	I	S	S	P	A	D	.	.	.	.	.	.	.	.	.	.	.	.	.	S	W	Y	V	S	Q	T	P	L	I	K	T	G	L	L	K	E	I	I	C	K	A	L	P	L	P
Query Conservation																																											.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																																											.	.	.	.	.	.	.	.	.	.	.	.	.																									.
Template Conservation																																																																																.
Template Sequence		K	V	K	S	G	Q	T	V	A	L	V	G	N	S	G	C	G	K	S	T	T	V	Q	L	M	Q	R	L	Y	D	P	L	D	G	M	V	S	I	D	G	Q	D	I	R	T	I	N	V	R	Y	L	R	E	I	I	G	V	V	S	Q	E	P	V	L	F	A	T	T	I	A	E	N	I	R	Y	G	R	E	.	D
Template Known Secondary structure					T	T									S	S	T	T								T	T	T	S	S			S							T	T			G	G	G	S														S	S					S	S											S	.	S
Template Predicted Secondary structure																																																																																.
Template SS confidence
		412	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.		490
		456	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.						480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530
Predicted Secondary structure																										.	.	.	.	.
Query SS confidence																										.	.	.	.	.
Query Sequence		V	D	D	K	S	L	S	E	V	L	H	Q	V	G	L	G	K	L	A	A	R	I	H	D	.	.	.	.	.	H	D	R	W	G	D	I	L	S	S	G	E	K	Q	R	I	A	L	A	R	L	I	L	R	R	P	K	W	I	F	L	D	E	T	T	S	H	L	E	E	Q	E	A	I	R	L	L	R	L	V	R
Query Conservation																										.	.	.	.	.
Alig confidence																										.	.	.	.	.
Template Conservation
Template Sequence		V	T	M	D	E	I	E	K	A	V	K	E	A	N	A	Y	D	F	I	M	K	L	P	H	Q	F	D	T	L	V	G	E	R	G	A	Q	L	S	G	G	Q	K	Q	R	I	A	I	A	R	A	L	V	R	N	P	K	I	L	L	L	D	E	A	T	S	A	L	D	T	E	S	E	A	V	V	Q	A	A	L	D
Template Known Secondary structure														T	T		T	T					S	T	T	G	G	G				S	S	S	S		S	S																			S						B	T	T		S	S
Template Predicted Secondary structure
Template SS confidence
		491	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570
		531	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	K	L	P	T	S	G	V	I	M	V	T	H	Q	P	G	V	W	N	L	A	D	D	I	C	D	I	S	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		K	A	R	E	G	R	T	T	I	V	I	A	H	R	L	S	T	V	R	N	A	D	V	I	A	G	F	D	G
Template Known Secondary structure				T	T	S	S							S						T	T		S						S	S
Template Predicted Secondary structure
Template SS confidence
		571	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.