Return to main results Retrieve Phyre Job Id

Job DescriptionP0AAG8
Confidence100.00%DateThu Jan 5 11:12:53 GMT 2012
Rank2Aligned Residues474
% Identity27%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   3......10.........20..... ....30.........40.........50.........60.........70.........
Predicted Secondary structure 










...
























Query SS confidence 






















. . .





















































Query Sequence  SSTTPSSGEYLLEMSGINKSFPG. . . VKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKDSGTILFQGKEIDF
Query Conservation      
      
   

   
  ...   
  

  
  

   


 








  
 
      
 
   
     
Alig confidence 






















...





















































Template Conservation             
                 
         
    
 
  







  
 
      
 
   
     
Template Sequence  SGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRT
Template Known Secondary structure 




TT
S



SSTTS

S
TT


SSTTTTTSS

STTGGG
Template Predicted Secondary structure 















































Template SS confidence 















































































   377..380.........390.........400.........410.........420.........430.........440.........450......
 
   80.........90.........100.........110.........120.........130....... ..140.........150.......
Predicted Secondary structure 




















..








Query SS confidence 

























































. .



















Query Sequence  HSAKEALENGISMVHQELNLVLQRSVMDNMWLGRYPTKGMFVDQDKMYRETKAIFDEL. . DIDIDPRARVGTLSVSQMQM
Query Conservation            
  
 
        

 
                              .. 
       
  




 

Alig confidence 




.
















.

































..



















Template Conservation       .         
   
   .
   

                                          

 

  
Template Sequence  INVRY. LREIIGVVSQEPVLFAT. TIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQR
Template Known Secondary structure  S
.SS



SS.

SS

TT
TTSTTGGG


SSSS
SS
Template Predicted Secondary structure 

.












.

























Template SS confidence 















































































   457..460. ........470........ .480.........490.........500.........510.........520.........530....
 
   158.160.........170.........180.........190.........200.........210.........220.........230.......
Predicted Secondary structure 

























Query SS confidence 















































































Query Sequence  IEIAKAFSYNAKIVIMDEPTSSLTEKEVNHLFTIIRKLKERGCGIVYISHKMEEIFQLCDEVTVLRDGQWIATEPLAGLT
Query Conservation 
 

 

   
 







  

      
   
  
   
 


 


    
    
 
  
  
  
         
Alig confidence 







































.














.






















Template Conservation    



      
  


    

      
         .  
 
   
      .  
 
     
     
    
 
Template Sequence  IAIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELM
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




Template Predicted Secondary structure 












.




.







Template SS confidence 















































































   535....540.........550.........560.........570.... .....580......... 590.........600.........610..
 
   238.240.........250.........260.
Predicted Secondary structure 



















........................................................
Query SS confidence 























. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  MDKIIAMMVGRSLNQRFPDKENKP. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation                          ........................................................
Alig confidence 























........................................................
Template Conservation                                                
                                 
Template Sequence  REKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSN
Template Known Secondary structure  TST









TTT



SS
STT
Template Predicted Secondary structure 



















Template SS confidence 















































































   613......620.........630.........640.........650.........660.........670.........680.........690..
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                
                   
   
   
               
 
  
   
           
Template Sequence  LFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRL
Template Known Secondary structure 

S
S

Template Predicted Secondary structure 












Template SS confidence 















































































   750.........760.........770.........780.........790.........800.........810.........820.........
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation     
          
        
 

 
    
                               
 
 
   

     
Template Sequence  AVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTRE
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
Template SS confidence 















































































   830.........840.........850.........860.........870.........880.........890.........900.........
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                                
  
                           
  
Template Sequence  QKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSS
Template Known Secondary structure 

TTTT
S
STTTS
Template Predicted Secondary structure 





Template SS confidence 















































































   910.........920.........930.........940.........950.........960.........970.........980.........
 
   262.......270..... ....280.........290.........
Predicted Secondary structure  .....................................








.....







Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .













. . . . .























Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GEVILEVRNLTSLR. . . . . QPSIRDVSFDLHKGEILGIAGLVG
Query Conservation  .....................................    
    
    .....   
  


 
  

   


 

Alig confidence  .....................................













.....























Template Conservation            
  

   
                    
 
    
   
       

  

  
  

 




 

Template Sequence  FAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSG
Template Known Secondary structure  SSS
SS




SS
S




TTT





S
GGG

SS


SSS
SSS
Template Predicted Secondary structure 





































Template SS confidence 















































































   990.........1000.........1010.........1020.........1030.........1040.........1050.........1060.........
 
   300.........310.........320.........330.........340.........350.........360.........370.........
Predicted Secondary structure 




































Query SS confidence 















































































Query Sequence  AKRTDIVETLFGIREKSAGTITLHGKQINNHNANEAINHGFALVTEERRSTGIYAYLDIGFNSLISNIRNYKNKVGLLDN
Query Conservation 






  
 
      
 
   
               
  
 
      
        
                  
Alig confidence 


































.












...



.





......










Template Conservation 






  
 
      
 
 
 
  
       .

  
  


   ...

  .





......           
Template Sequence  CGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQW. LRAQLGIVSQEPI. . . LFDC. SIAENI. . . . . . AYGDNSRVVSY
Template Known Secondary structure  TTTTSS

SSSSS
BTSS
.TTS
SS

...

SS.B......T


SS



Template Predicted Secondary structure 













.




...



.
......







Template SS confidence 















































































   1070.........1080.........1090.........1100.... .....1110....... ..1120. ...... ..1130........
 
   380........ .390.........400...... ...410.........420.........430.........440.........450...
Predicted Secondary structure  ..







....












Query SS confidence 








. .

















. . . .














































Query Sequence  SRMKSDTQW. . VIDSMRVKTPGHRTQIGS. . . . LSGGNQQKVIIGRWLLTQPEILMLDEPTRGIDVGAKFEIYQLIAELA
Query Conservation           .. 
    
        
  ....








 




   
 








 

      
   
    
Alig confidence 








..

















....














































Template Conservation    
   
    
   
  
  


  
   
  

 





 





    








 

      
   
    
Template Sequence  EEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR
Template Known Secondary structure  T
SSTTTGGG
B
STTS
SS


SSS
SSS

S
Template Predicted Secondary structure 





























Template SS confidence 















































































   11391140.........1150.........1160.........1170.........1180.........1190.........1200.........1210........
 
   454.....460.........470.........480.........490...
Predicted Secondary structure 









Query SS confidence 







































Query Sequence  KKGKGIIIISSEMPELLGITDRILVMSNGLVSGIVDTKTT
Query Conservation    
 







       



  
  
 
       
 
Alig confidence  .
















.




















Template Conservation  .   


 


       . 
 
 

  
 
 
 
    
Template Sequence  . EGRTCIVIAHRLSTIQN. ADLIVVIQNGKVKEHGTHQQL
Template Known Secondary structure  .SSS

S
TTGGGS.
STB
Template Predicted Secondary structure  .





.





Template SS confidence 







































   12191220.........1230..... ....1240.........1250......
 
Download:Text version FASTA pairwise alignment 3D Model in PDB format

View in Jmol

Send structure to FirstGlance for more viewing options


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
Disclaimer
Terms and Conditions