Secondary structure and disorder prediction

1

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10

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20

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30

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40

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50

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60

Sequence

M

K

I

I

S

F

V

L

P

C

L

L

V

L

A

G

C

S

T

P

S

Q

P

E

A

P

K

P

P

Q

I

G

M

A

N

P

A

S

V

Y

C

Q

Q

K

G

G

T

L

I

P

V

Q

T

A

Q

G

V

S

N

N

Secondary structure

SS confidence

Disorder

?

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?

?

?

?

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?

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?

Disorder confidence

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70

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80

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Sequence

C

K

L

P

G

G

E

T

I

D

E

W

A

L

W

R

R

D

H

P

A

G

E

K

Secondary structure

SS confidence

Disorder

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Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3hwp chain A Region: 57 - 68 Aligned: 12 Modelled: 10 Confidence: 40.6% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:phlg; PDBTitle: crystal structure and computational analyses provide insights into the2 catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase phlg3 from pseudomonas fluorescens Phyre2 PDB 1fd3 chain A Region: 32 - 69 Aligned: 36 Modelled: 38 Confidence: 28.3% Identity: 28% Fold: Defensin-like Superfamily: Defensin-like Family: Defensin Phyre2 PDB 2coh chain A domain 2 Region: 32 - 82 Aligned: 51 Modelled: 51 Confidence: 22.1% Identity: 18% Fold: Double-stranded beta-helix Superfamily: cAMP-binding domain-like Family: cAMP-binding domain Phyre2 PDB 3k0z chain B Region: 58 - 75 Aligned: 18 Modelled: 18 Confidence: 21.6% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of putative polyketide cyclase (np_977253.1) from2 bacillus cereus atcc 10987 at 1.91 a resolution Phyre2 PDB 1wk1 chain A Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 19.6% Identity: 29% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1rdl chain 1 Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 19.6% Identity: 24% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 2gey chain A domain 1 Region: 58 - 75 Aligned: 18 Modelled: 18 Confidence: 17.6% Identity: 11% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 1mpu chain A Region: 37 - 55 Aligned: 19 Modelled: 19 Confidence: 16.3% Identity: 16% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 3bdw chain A domain 1 Region: 37 - 55 Aligned: 19 Modelled: 19 Confidence: 14.9% Identity: 16% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1r13 chain A domain 1 Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 14.7% Identity: 24% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1zhv chain A domain 1 Region: 55 - 74 Aligned: 20 Modelled: 20 Confidence: 14.4% Identity: 30% Fold: Ferredoxin-like Superfamily: ACT-like Family: Atu0741-like Phyre2 PDB 1hup chain A Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 13.9% Identity: 6% PDB header:c-type lectin Chain: A: PDB Molecule:mannose-binding protein; PDBTitle: human mannose binding protein carbohydrate recognition domain2 trimerizes through a triple alpha-helical coiled-coil Phyre2 PDB 1hup chain A domain 1 Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 13.3% Identity: 6% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1fif chain A domain 1 Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 12.6% Identity: 18% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 2msb chain A Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 11.9% Identity: 18% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1egg chain A Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 11.8% Identity: 24% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 3kkg chain A Region: 58 - 75 Aligned: 18 Modelled: 18 Confidence: 11.6% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:putative snoal-like polyketide cyclase; PDBTitle: crystal structure of putative snoal-like polyketide cyclase2 (yp_509242.1) from jannaschia sp. ccs1 at 1.40 a resolution Phyre2 PDB 1ja3 chain A Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 11.6% Identity: 12% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 3ehc chain A Region: 58 - 75 Aligned: 18 Modelled: 18 Confidence: 11.4% Identity: 6% PDB header:unknown function Chain: A: PDB Molecule:snoal-like polyketide cyclase; PDBTitle: crystal structure of a snoal-like polyketide cyclase (atu3018) from2 agrobacterium tumefaciens str. c58 at 2.12 a resolution Phyre2 PDB 3cfw chain A Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 11.1% Identity: 24% PDB header:cell adhesion Chain: A: PDB Molecule:l-selectin; PDBTitle: l-selectin lectin and egf domains Phyre2 1 c3hwpA_ 2 d1fd3a_ 3 d2coha2 4 c3k0zB_ 5 d1wk1a_ 6 d1rdl1_ 7 d2geya1 8 d1mpua_ 9 d3bdwa1 10 d1r13a1 11 d1zhva1 12 c1hupA_ 13 d1hupa1 14 d1fifa1 15 d2msba_ 16 d1egga_ 17 c3kkgA_ 18 d1ja3a_ 19 c3ehcA_ 20 c3cfwA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3hwpA_ 40.6 33 PDB header:hydrolase Chain: A: PDB Molecule:phlg; PDBTitle: crystal structure and computational analyses provide insights into the2 catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase phlg3 from pseudomonas fluorescens 2 d1fd3a_ 28.3 28 Fold:Defensin-like Superfamily:Defensin-like Family:Defensin 3 d2coha2 22.1 18 Fold:Double-stranded beta-helix Superfamily:cAMP-binding domain-like Family:cAMP-binding domain 4 c3k0zB_ 21.6 17 PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of putative polyketide cyclase (np_977253.1) from2 bacillus cereus atcc 10987 at 1.91 a resolution 5 d1wk1a_ 19.6 29 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 6 d1rdl1_ 19.6 24 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 7 d2geya1 17.6 11 Fold:Cystatin-like Superfamily:NTF2-like Family:SnoaL-like polyketide cyclase 8 d1mpua_ 16.3 16 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 9 d3bdwa1 14.9 16 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 10 d1r13a1 14.7 24 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 11 d1zhva1 14.4 30 Fold:Ferredoxin-like Superfamily:ACT-like Family:Atu0741-like 12 c1hupA_ 13.9 6 PDB header:c-type lectin Chain: A: PDB Molecule:mannose-binding protein; PDBTitle: human mannose binding protein carbohydrate recognition domain2 trimerizes through a triple alpha-helical coiled-coil 13 d1hupa1 13.3 6 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 14 d1fifa1 12.6 18 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 15 d2msba_ 11.9 18 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 16 d1egga_ 11.8 24 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 17 c3kkgA_ 11.6 17 PDB header:lyase Chain: A: PDB Molecule:putative snoal-like polyketide cyclase; PDBTitle: crystal structure of putative snoal-like polyketide cyclase2 (yp_509242.1) from jannaschia sp. ccs1 at 1.40 a resolution 18 d1ja3a_ 11.6 12 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 19 c3ehcA_ 11.4 6 PDB header:unknown function Chain: A: PDB Molecule:snoal-like polyketide cyclase; PDBTitle: crystal structure of a snoal-like polyketide cyclase (atu3018) from2 agrobacterium tumefaciens str. c58 at 2.12 a resolution 20 c3cfwA_ 11.1 24 PDB header:cell adhesion Chain: A: PDB Molecule:l-selectin; PDBTitle: l-selectin lectin and egf domains 21 d1byfa_ not modelled 11.0 32 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 22 d1pwba1 not modelled 10.8 35 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 23 d1c9fa_ not modelled 10.7 14 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:CAD domain 24 d2gexa1 not modelled 10.7 11 Fold:Cystatin-like Superfamily:NTF2-like Family:SnoaL-like polyketide cyclase 25 c3ff7C_ not modelled 10.5 12 PDB header:cell adhesion/immunue system Chain: C: PDB Molecule:killer cell lectin-like receptor subfamily g PDBTitle: structure of nk cell receptor klrg1 bound to e-cadherin 26 d1g1ta1 not modelled 10.5 47 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 27 d1rjha_ not modelled 10.1 53 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 28 d1g1sa1 not modelled 10.0 29 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 29 d2f99a1 not modelled 9.9 6 Fold:Cystatin-like Superfamily:NTF2-like Family:SnoaL-like polyketide cyclase 30 d1tkea1 not modelled 9.9 33 Fold:beta-Grasp (ubiquitin-like) Superfamily:TGS-like Family:TGS domain 31 c1rpuA_ not modelled 9.3 43 PDB header:rna binding protein/rna Chain: A: PDB Molecule:19 kda protein; PDBTitle: crystal structure of cirv p19 bound to sirna 32 d1rpua_ not modelled 9.3 43 Fold:Tombusvirus P19 core protein, VP19 Superfamily:Tombusvirus P19 core protein, VP19 Family:Tombusvirus P19 core protein, VP19 33 c1r13A_ not modelled 9.2 24 PDB header:sugar binding protein Chain: A: PDB Molecule:pulmonary surfactant-associated protein a; PDBTitle: carbohydrate recognition and neck domains of surfactant protein a (sp-2 a) 34 c1kwwC_ not modelled 8.7 18 PDB header:immune system, sugar binding protein Chain: C: PDB Molecule:mannose-binding protein a; PDBTitle: rat mannose protein a complexed with a-me-fuc. 35 c3m9zA_ not modelled 8.6 41 PDB header:signaling protein Chain: A: PDB Molecule:killer cell lectin-like receptor subfamily b member 1a; PDBTitle: crystal structure of extracellular domain of mouse nkr-p1a 36 c3f9sB_ not modelled 8.3 11 PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (lferr_0659) from2 acidithiobacillus ferrooxidans atcc at 1.76 a resolution 37 c2eelA_ not modelled 7.9 17 PDB header:apoptosis Chain: A: PDB Molecule:cell death activator cide-a; PDBTitle: solution structure of the cide-n domain of human cell death2 activator cide-a 38 d1qo3d_ not modelled 7.3 18 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 39 c2vuvA_ not modelled 7.1 41 PDB header:sugar-binding protein Chain: A: PDB Molecule:codakine; PDBTitle: crystal structure of codakine at 1.3a resolution 40 c3g8lD_ not modelled 6.9 16 PDB header:immune system Chain: D: PDB Molecule:lectin-related nk cell receptor ly49l1; PDBTitle: crystal structure of murine natural killer cell receptor,2 ly49l4 41 c1eslA_ not modelled 6.9 47 PDB header:cell adhesion protein Chain: A: PDB Molecule:human e-selectin; PDBTitle: insight into e-selectin(slash)ligand interaction from the2 crystal structure and mutagenesis of the lec(slash)egf3 domains 42 d1sjwa_ not modelled 6.7 11 Fold:Cystatin-like Superfamily:NTF2-like Family:SnoaL-like polyketide cyclase 43 c1zhvA_ not modelled 6.6 28 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein atu0741; PDBTitle: x-ray crystal structure protein atu0741 from agobacterium tumefaciens.2 northeast structural genomics consortium target atr8. 44 c1wwtA_ not modelled 6.6 44 PDB header:ligase Chain: A: PDB Molecule:threonyl-trna synthetase, cytoplasmic; PDBTitle: solution structure of the tgs domain from human threonyl-2 trna synthetase 45 d3c8ja1 not modelled 6.4 18 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 46 d1hq8a_ not modelled 6.3 11 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 47 c1fm5A_ not modelled 6.0 29 PDB header:immune system Chain: A: PDB Molecule:early activation antigen cd69; PDBTitle: crystal structure of human cd69 48 c2jyvA_ not modelled 6.0 29 PDB header:cytokine Chain: A: PDB Molecule:granulin-2; PDBTitle: human granulin f 49 d1r62a_ not modelled 5.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 50 d1qo3c_ not modelled 5.8 18 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 51 c3bc6D_ not modelled 5.8 24 PDB header:immune system Chain: D: PDB Molecule:c-type lectin domain family 4 member k; PDBTitle: the carbohydrate recognition domain of langerin reveals high2 structural similarity with the one of dc-sign but an additional,3 calcium-independent sugar-binding site 52 c3pzdB_ not modelled 5.8 83 PDB header:motor protein/apoptosis Chain: B: PDB Molecule:netrin receptor dcc; PDBTitle: structure of the myosin x myth4-ferm/dcc complex 53 d1e87a_ not modelled 5.8 29 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:C-type lectin domain 54 c3g0kA_ not modelled 5.8 19 PDB header:ca-binding protein Chain: A: PDB Molecule:putative membrane protein; PDBTitle: crystal structure of a protein of unknown function with a cystatin-2 like fold (saro_2880) from novosphingobium aromaticivorans dsm at3 1.30 a resolution 55 c3g8zA_ not modelled 5.6 6 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:protein of unknown function with cystatin-like fold; PDBTitle: crystal structure of protein of unknown function with cystatin-like2 fold (np_639274.1) from xanthomonas campestris at 1.90 a resolution 56 c3dbzB_ not modelled 5.4 35 PDB header:sugar binding protein Chain: B: PDB Molecule:pulmonary surfactant-associated protein d; PDBTitle: human surfactant protein d 57 d1ibxa_ not modelled 5.3 17 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:CAD domain 58 c3i0yC_ not modelled 5.1 6 PDB header:isomerase Chain: C: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (xcc0381) from2 xanthomonas campestris pv. campestris at 1.50 a resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0