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Job DescriptionP0A698
Confidence100.00%DateThu Jan 5 11:02:38 GMT 2012
Rank5Aligned Residues454
% Identity34%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   2.......10... ......20.........30.........40.........50.........60.........70...
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Query Sequence  DKIEVRGARTHN. . . . . . . . LKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDV
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Template Sequence  GNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTV. . . . . . . . . . . . . . . . . . . . . QLMQRLYDPLD
Template Known Secondary structure 



SSTTS

S
TT


SSTT.....................TTTSS

S
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   386...390.........400.........410.........420.........430... ......440....
 
   74.. ...80.... .....90.........100.........110.........120.........130.........140
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Query Sequence  DHI. . . . . . . . . . . . EGLSPAIS. IEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRCPDHDVPLAAQTVSQMVDNVL
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Template Sequence  GMVSIDGQDIRTINVRYLREIIGVVSQEPVLFA. . . . . TTIAE. . . . . NIRYGR. . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  TTGGGS
SS



S.....S
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   445....450.........460.........470....... ..480.. ......
 
   141........150.........160.........170.........180.........190.........200.........210.........220
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Query Sequence  SQPEGKRLMLLAPIIKERKGEHTKTLENLASQGYIRARIDGEVCDLSDPPKLELQKKHTIEVVVDRFKVRDDLTQRLAES
Query Conservation        

 
   
                  
            
                
     
       
  
Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   221........230.........240.........250.........260.........270.........280.........290.........300
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Query Sequence  FETALELSGGTAVVADMDDPKAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQNPEL
Query Conservation                             
                   

 

  
 
  
 
 
     
    
 
   
Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   301........310.........320.........330.........340.........350.........360.........370.........380
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Query Sequence  SLAGGAIRGWDRRNFYYFQMLKSLADHYKFDVEAPWGSLSANVHKVVLYGSGKENIEFKYMNDRGDTSIRRHPFEGVLHN
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Template Conservation  .............                    ..           ..................................
Template Sequence  . . . . . . . . . . . . . EDVTMDEIEKAVKEANAYDF. . IMKLPHQFDTL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  .............SS

TT
TT..STTGGG

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   489490.........500........ .510.........
 
   381........390.........400.........410.........420.........430.........440.........450.........460
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Query Sequence  MERRYKETESSAVREELAKFISNRPCASCEGTRLRREARHVYVENTPLPAISDMSIGHAMEFFNNLKLAGQRAKIAEKIL
Query Conservation                  
        
  
 
 

   
  
 
 
  
       
         
              
Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ................................................................................
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   461........470.........480.........490.........500.........510.........520.........530.........540
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Query Sequence  KEIGDRLKFLVNVGLNYLTLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRDLGNT
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Template Sequence  . . . . . . . . . . . . . . . . . . . VGERGAQLSGGQKQRIAIARALVRNPK. . ILLLDEATSALDTESEAVVQAALDKAR. EGRT
Template Known Secondary structure  ...................
SSSS
SS


S..BTT
SS
T.TSS
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   520.........530.........540...... ...550.........560.........570... ....
 
   541........550.........560.........570.........580.........590......
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Query Sequence  VIVVEHDEDAIRAADHVIDIGPGAGVHGGEVVAEGPLEAIMAVPESLTGQYMSGKR. . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation   
   
        
 
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Template Sequence  TIVIAHRLSTVRNADVIAGF. . . . . . DGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFV
Template Known Secondary structure 
S
TT
S
......SSS




TST









TTT



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   578.580.........590....... ..600.........610.........620.........630.........640.........650.
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation         
                                               
                   
   
Template Sequence  VGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMV
Template Known Secondary structure  SS
STT
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   709710.........720.........730.........740.........750.........760.........770.........780........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation     
               
 
  
   
           
   
          
        
 

 
    
     
Template Sequence  FKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAG
Template Known Secondary structure 

S
S

SS
STT
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   789790.........800.........810.........820.........830.........840.........850.........860........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                            
 
 
   

                                            
Template Sequence  VVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFS
Template Known Secondary structure  TT
TTTTT
SS
Template Predicted Secondary structure 
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   869870.........880.........890.........900.........910.........920.........930.........940........
 
   597..600.........610
Predicted Secondary structure  ..................................................................






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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . KIEVPKKRVPANPE
Query Conservation  ..................................................................              
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Template Conservation         
  
                           
            
  

   
                    
Template Sequence  YAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLE
Template Known Secondary structure 

TTTT
S
STTTSSSS
SS




SS
S




TTT

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   949950.........960.........970.........980.........990.........1000.........1010.........1020........
 
   611........620.. .......630.........640.........650.........660.........670.........680..
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Query Sequence  KVLKLTGARGNN. . . . . . . . LKDVTLTLPVGLFTCITGVSGSGKSTLINDTLFPIAQRQLNGATIAEPAPYRDIQGLEHF
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Template Sequence  GNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ. . LLERFYDPMAGSVFLDGKEIKQLNVQWLR
Template Known Secondary structure 



S
GGG

SS


SSS
SSSTT..TTSS

SSSSS
BTSS
T
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   10291030.........1040.........1050.........1060.........1070....... ..1080.........1090.........1100......
 
   683......690.........700.........710.........720.........730.........740.........750.........760..
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Query Sequence  DKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPESRARGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVP
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Template Conservation    
  


   

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Template Sequence  AQLGIVSQEPILF. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  TS
SS



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   1107..1110.........
 
   763......770.........780.........790.........800... ......810.........820.. .......830
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Query Sequence  CDQCKGKRYNRETLEIKYKGKTIHEVLDMTIEEAREFFDAV. . PALARKLQTLMDVGLTYIR. . . . . . . . . . LGQSATTL
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Template Conservation  ...........................  





             
   
    
   
  
  


  
   
  
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . DCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQL
Template Known Secondary structure  ...........................SSBT


SS



T
SSTTTGGG
B
STTS
SS
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   1120.........1130.........1140.........1150.........1160.........1170..
 
   831........840.........850.........860.........870.........880.........890.........900.........910
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Query Sequence  SGGEAQRVKLARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHKLRDQGNTIVVIEHNLDVIKTADWIVDLGPEGGS
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Template Sequence  SGGQKQRIAIARALVRQPH. . . ILLLDEATSALDTESEKVVQEALDKAR. EGRTCIVIAHRLSTIQNADLIVVI. . . . . .
Template Known Secondary structure 


S...SS
SSS

S.SSS

S
TTGGGS
S......
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   1173......1180.........1190. ........1200.........1210........ .1220.........1230.........1240..
 
   911........920.........930.....
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Query Sequence  GGGEILVSGTPETVAECEASHTARF
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Template Conservation    
 
 
 
    
    
    
 
Template Sequence  QNGKVKEHGTHQQLLAQKGIYFSMV
Template Known Secondary structure  TB
S
S
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   1243......1250.........1260.......
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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