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Job DescriptionQ6BEX0
Confidence100.00%DateThu Jan 5 12:37:24 GMT 2012
Rank2Aligned Residues468
% Identity29%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   4.....10......... 20.........30.........40.........50.........60.........70.........80
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Query Sequence  DQHQEILRTEGLSKFF. . . PGVKALDNVDFSLRRGEIMALLGENGAGKSTLIKALTGVYHADRGTIWLEGQAISPKNTAH
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Template Sequence  DNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY
Template Known Secondary structure  TT
S



SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   382.......390.........400.........410.........420.........430.........440.........450.........460.
 
   81........90.........100.........110.........120.........130... ......140.........150........
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Query Sequence  AQQLGIGTVYQEVNLLPNMSVADNLFIGREPKRFGLLRRKEMEKRATELMASY. . GFSLDVREPLNRFSVAMQQIVAICR
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Template Sequence  LREI. IGVVSQEPVLFAT. TIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIAR
Template Known Secondary structure  .SS



SS.

SS

TT
TTSTTGGG


SSSS
SS
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   462... ....470........ .480.........490.........500.........510.........520.........530.........
 
   159160.........170.........180.........190.........200.........210.........220.........230........
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Query Sequence  AIDLSAKVLILDEPTASLDTQEVELLFDLMRQLRDRGVSLIFVTHFLDQVYQVSDRITVLRNGSFVGCRETCELPQIELV
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Template Sequence  ALVRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELMREKGI
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




TS
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   540.........550.........560.........570.... .....580......... 590.........600.........610.......
 
   239240...
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Query Sequence  KMMLG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                           
                                      
Template Sequence  YFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLL
Template Known Secondary structure  T









TTT



SS
STT
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   618.620.........630.........640.........650.........660.........670.........680.........690.......
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation           
                   
   
   
               
 
  
   
           
   
 
Template Sequence  FLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQ
Template Known Secondary structure 

S
S

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   755....760.........770.........780.........790.........800.........810.........820.........830....
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation           
        
 

 
    
                               
 
 
   

          
Template Sequence  NIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFET
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   835....840.........850.........860.........870.........880.........890.........900.........910....
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                           
  
                           
       
Template Sequence  MYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDY
Template Known Secondary structure 

TTTT
S
STTTSSSS
S
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   915....920.........930.........940.........950.........960.........970.........980.........990....
 
   244.....250.........260......... 270.........280.........290.........300.
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Query Sequence  . . . . . . . . . . . . . . . RELDTHALQRAGRTLLSDKPVAAFKN. . . . . . . YGKKGTIAPFDLEVRPGEIVGLAGLLGSGRTE
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Template Sequence  AKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKST
Template Known Secondary structure  S




SS
S




TTT





S
GGG

SS


SSS
SSSTT
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   995....1000.........1010.........1020.........1030.........1040.........1050.........1060.........1070....
 
   302.......310.........320.........330.........340.........350.........360.........370.........380.
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Query Sequence  TAEVIFGIKPADSGTALIKGKPQNLRSPHQASVLGIGFCPEDRKTDGIIAAASVRENIILALQAQRGWLRPISRKEQQEI
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Template Sequence  VVQLLERFYDPMAGSVFLDGKEIKQLNVQ. WLRAQLGIVSQEPI. . . . LFDCSIAENIAYGDN. . . . . SRVVSYEE. . . .
Template Known Secondary structure  TTSS

SSSSS
BTSS
.TTS
SS

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SSBT


S.....S



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   1075....1080.........1090.........1100... ......1110....... ..1120.........1130.. .......1140
 
   382.......390.........400 .........410.........420.........430.........440.........450.
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Query Sequence  AERFIRQLGIRTPSTEQPI. . . . . . . . . . EFLSGGNQQKVLLSRWLLTRPQFLILDEPTRGIDVGAHAEIIRLIETLCAD
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Template Sequence  IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR. E
Template Known Secondary structure  T
SSTTTGGG
B
STTS
SS


SSS
SSS

S.S
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   1141........1150.........1160.........1170.........1180.........1190.........1200.........1210........ .
 
   452.......460.........470.........480.........490.
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Query Sequence  GLALLVISSELEELVGYADRVIIMRDRKQVAEIPLAELSV
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Template Sequence  GRTCIVIAHRLSTIQN. ADLIVVIQNGKVKEHGTHQQLLA
Template Known Secondary structure  SS

S
TTGGGS.
STB
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   1220.........1230..... ....1240.........1250........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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