Job Description P60752 Confidence 100.00% Date Thu Jan 5 12:07:07 GMT 2012 Rank 5 Aligned Residues 569 % Identity 31% Template c3g5uB_ PDB info PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Resolution 3.80 Å

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		13	.	.	.	.	.	.	20	.	.	.		.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60																					.	.	.	.	.	.	.	.	.	70	.
Predicted Secondary structure													.																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence													.																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		F	R	R	L	W	P	T	I	A	P	F	.	K	A	G	L	I	V	A	G	V	A	L	I	L	N	A	A	S	D	T	F	M	L	S	L	L	K	P	L	L	D	D	G	F	G	K	T	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	R	S	V	L	V	W	M	P	L	V	V
Query Conservation													.																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence													.																																						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		V	L	T	M	F	R	Y	A	G	W	L	D	R	L	Y	M	L	V	G	T	L	A	A	I	I	H	G	V	A	L	P	L	M	M	L	I	F	G	D	M	T	D	S	F	A	S	V	G	N	V	S	K	N	S	T	N	M	S	E	A	D	K	R	A	M	F	A	K	L	E	E	E	M	T	T	Y	A	Y	Y	Y
Template Known Secondary structure		T					T																																																	S	S		S
Template Predicted Secondary structure
Template SS confidence
		35	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.
		72	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	G	L	M	I	L	R	G	I	T	S	Y	V	S	S	Y	C	I	S	W	V	S	G	K	V	V	M	T	M	R	R	R	L	F	G	H	M	M	G	M	P	V	S	F	F	D	K	Q	S	T	G	T	L	L	S	R	I	T	Y	D	S	E	Q	V	A	S	S	S	S	G	A	L	I	T	V	V	R	E	G	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		T	G	I	G	A	G	V	L	I	V	A	Y	I	Q	V	S	F	W	C	L	A	A	G	R	Q	I	H	K	I	R	Q	K	F	F	H	A	I	M	N	Q	E	I	G	W	F	D	V	H	D	V	G	E	L	N	T	R	L	T	D	D	V	S	K	I	N	E	G	I	G	D	K	I	G	M	F	F	Q	A	M	A
Template Known Secondary structure																																										T	T					S	S		S
Template Predicted Secondary structure
Template SS confidence
		115	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.
		152	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	I	I	G	L	F	I	M	M	F	Y	Y	S	W	Q	L	S	I	I	L	I	V	L	A	P	I	V	S	I	A	I	R	V	V	S	K	R	F	R	N	I	S	K	N	M	Q	N	T	M	G	Q	V	T	T	S	A	E	Q	M	L	K	G	H	K	E	V	L	I	F	G	G	Q	E	V	E	T	K	R	F	D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		T	F	F	G	G	F	I	I	G	F	T	R	G	W	K	L	T	L	V	I	L	A	I	S	P	V	L	G	L	S	A	G	I	W	A	K	I	L	S	S	F	T	D	K	E	L	H	A	Y	A	K	A	G	A	V	A	E	E	V	L	A	A	I	R	T	V	I	A	F	G	G	Q	K	K	E	L	E	R	Y	N
Template Known Secondary structure													T	T	T	T	S																																							T	T	T											T	T					S
Template Predicted Secondary structure
Template SS confidence
		195	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.
		232	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	V	S	N	R	M	R	L	Q	G	M	K	M	V	S	A	S	S	I	S	D	P	I	I	Q	L	I	A	S	L	A	L	A	F	V	L	Y	A	A	S	F	P	S	V	M	D	S	L	T	A	G	T	I	T	V	V	F	S	S	M	I	A	L	M	R	P	L	K	S	L	T	N	V	N	A	Q	F	Q	R	G
Query Conservation
Alig confidence
Template Conservation
Template Sequence		N	N	L	E	E	A	K	R	L	G	I	K	K	A	I	T	A	N	I	S	M	G	A	A	F	L	L	I	Y	A	S	Y	A	L	A	F	W	Y	G	T	S	L	V	I	S	K	E	Y	S	I	G	Q	V	L	T	V	F	F	S	V	L	I	G	A	F	S	V	G	Q	A	S	P	N	I	E	A	F	A	N	A
Template Known Secondary structure													T	T	T																																S	S	S		S	S
Template Predicted Secondary structure
Template SS confidence
		275	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.
		312	.	.	.	.	.	.	.	320	.	.	.	.	.				.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.		.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.
Predicted Secondary structure																.	.	.																											.
Query SS confidence																.	.	.																											.
Query Sequence		M	A	A	C	Q	T	L	F	T	I	L	D	S	E	.	.	.	Q	E	K	D	E	G	K	R	V	I	E	R	A	T	G	D	V	E	F	R	N	V	T	F	T	Y	.	P	G	R	D	V	P	A	L	R	N	I	N	L	K	I	P	A	G	K	T	V	A	L	V	G	R	S	G	S	G	K	S	T	I	A	S
Query Conservation																.	.	.																											.
Alig confidence																.	.	.																											.
Template Conservation
Template Sequence		R	G	A	A	Y	E	V	F	K	I	I	D	N	K	P	S	I	D	S	F	S	K	S	G	H	K	P	D	N	I	Q	G	N	L	E	F	K	N	I	H	F	S	Y	P	S	R	K	E	V	Q	I	L	K	G	L	N	L	K	V	K	S	G	Q	T	V	A	L	V	G	N	S	G	C	G	K	S	T	T	V	Q
Template Known Secondary structure											T	T	S						S	S			S						T	T		S													S	S	T	T	S			S										T	T									S	S	T	T
Template Predicted Secondary structure
Template SS confidence
		355	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.
		388	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	I	T	R	F	Y	D	I	D	E	G	E	I	L	M	D	G	H	D	L	R	E	Y	T	L	A	S	L	R	N	Q	V	A	L	V	S	Q	N	V	H	L	F	N	D	T	V	A	N	N	I	A	Y	A	R	T	E	Q	Y	S	R	E	Q	I	E	E	A	A	R	M	A	Y	A	M	D	F	I	N	K	M	D
Query Conservation
Alig confidence																																																								.
Template Conservation																																																								.
Template Sequence		L	M	Q	R	L	Y	D	P	L	D	G	M	V	S	I	D	G	Q	D	I	R	T	I	N	V	R	Y	L	R	E	I	I	G	V	V	S	Q	E	P	V	L	F	A	T	T	I	A	E	N	I	R	Y	G	R	.	E	D	V	T	M	D	E	I	E	K	A	V	K	E	A	N	A	Y	D	F	I	M	K	L	P
Template Known Secondary structure			T	T	T	S	S			S							T	T			G	G	G	S														S	S					S	S											.	S	S													T	T		T	T					S	T
Template Predicted Secondary structure																																																								.
Template SS confidence
		435	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.		.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.
		468	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	G	L	D	T	V	I	G	E	N	G	V	L	L	S	G	G	Q	R	Q	R	I	A	I	A	R	A	L	L	R	D	S	P	I	L	I	L	D	E	A	T	S	A	L	D	T	E	S	E	R	A	I	Q	A	A	L	D	E	L	Q	K	N	R	T	S	L	V	I	A	H	R	L	S	T	I	E	K	A	D	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		H	Q	F	D	T	L	V	G	E	R	G	A	Q	L	S	G	G	Q	K	Q	R	I	A	I	A	R	A	L	V	R	N	P	K	I	L	L	L	D	E	A	T	S	A	L	D	T	E	S	E	A	V	V	Q	A	A	L	D	K	A	R	E	G	R	T	T	I	V	I	A	H	R	L	S	T	V	R	N	A	D	V
Template Known Secondary structure		T	G	G	G				S	S	S	S		S	S																			S						B	T	T		S	S																T	T	S	S							S						T	T		S
Template Predicted Secondary structure
Template SS confidence
		514	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.
		548	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	V	V	V	E	D	G	V	I	V	E	R	G	T	H	N	D	L	L	E	H	R	G	V	Y	A	Q	L	H	K	M	Q	F	G	Q
Query Conservation
Alig confidence
Template Conservation
Template Sequence		I	A	G	F	D	G	G	V	I	V	E	Q	G	N	H	D	E	L	M	R	E	K	G	I	Y	F	K	L	V	M	T	Q	T	L	D
Template Known Secondary structure						S	S	S															T	S									T
Template Predicted Secondary structure
Template SS confidence
		594	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.