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Job DescriptionP32721
Confidence100.00%DateThu Jan 5 11:50:44 GMT 2012
Rank2Aligned Residues487
% Identity25%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   6...10..... ....20.........30.........40.........50.........60.........70.........80..
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Query Sequence  ISMAGIGKSF. . . GPVHALKSVNLTVYPGEIHALLGENGAGKSTLMKVLSGIHEPTKGTITINNISYNKLDHKLAAQLGI
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREI. I
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460..... .
 
   83......90.........100.........110.........120.........130... ......140.........150.........160
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Query Sequence  GIIYQELSVIDELTVLENLYIGRHLTKKICGVNIIDWREMRVRAAMMLLRV. . GLKVDLDEKVANLSISHKQMLEIAKTL
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Template Sequence  GVVSQEPVLFAT. TIAENIRYGREDVTM. . . . DEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARAL
Template Known Secondary structure  SS



SS.

SS

....TT
TTSTTGGG


SSSS
SS
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   467..470........ .480.........490... ......500.........510.........520.........530.........540.
 
   161........170.........180.........190.........200.........210.........220.........230.........240
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Query Sequence  MLDAKVIIMDEPTSSLTNKEVDYLFLIMNQLRKEGTAIVYISHKLAEIRRICDRYTVMKDGSSVCSGIVSDVSNDDIVRL
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Template Conservation       
  


    

      
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Template Sequence  VRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELMREKGIYF
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




TS
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   542.......550.........560.........570.... .....580......... 590.........600.........610.........
 
   241........250....
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Query Sequence  MVGRELQNRFNAMK. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                         
                                        
Template Sequence  KLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFL
Template Known Secondary structure  T









TTT



SS
STT
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   620.........630.........640.........650.........660.........670.........680.........690.........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation         
                   
   
   
               
 
  
   
           
   
   
Template Sequence  ILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNI
Template Known Secondary structure 

S
S

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   757..760.........770.........780.........790.........800.........810.........820.........830......
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation         
        
 

 
    
                               
 
 
   

            
Template Sequence  ANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMY
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   837..840.........850.........860.........870.........880.........890.........900.........910......
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                         
  
                           
         
Template Sequence  AQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAK
Template Known Secondary structure 

TTTT
S
STTTSSSS
S
Template Predicted Secondary structure 





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   917..920.........930.........940.........950.........960.........970.........980.........990......
 
   255....260.........270..... ....280.........290.........300......
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . ENVSNLAHETVFEVRNVTSRD. . . . . RKKVRDISFSVCRGEILGFAGLVGSGRTELM
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Template Sequence  ATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
Template Known Secondary structure  S




SS
S




TTT





S
GGG

SS


SSS
SSSTT
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   997..1000.........1010.........1020.........1030.........1040.........1050.........1060.........1070......
 
   307..310.........320.........330.........340.........350.........360.........370.........380......
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Query Sequence  NCLFGVDKRAGGEIRLNGKDISPRSPLDAVKKGMAYITESRRDNGFFPNFSIAQNMAISRSLKDGGYKGAMGLFHEVDEQ
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Template Sequence  QLLERFYDPMAGSVFLDGKEIKQLNV. QWLRAQLGIVSQEP. . . . ILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIH
Template Known Secondary structure  TTSS

SSSSS
BTSS
.TTS
SS
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SSBT


SS



T
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   1077..1080.........1090.........1100.. .......1110...... ...1120.........1130.........1140.........1150.
 
   387..390.........400.........410.........420.........430.........440.........450.........460......
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Query Sequence  RTAENQRELLALKCHSVNQNITELSGGNQQKVLISKWLCCCPEVIIFDEPTRGIDVGAKAEIYKVMRQLADDGKVILMVS
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Template Sequence  QFIDSLPDKYNTR. . . VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR. EGRTCIVIA
Template Known Secondary structure  SSTTTGGG
B...
STTS
SS


SSS
SSS

S.SSS

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   1152.......1160.... .....1170.........1180.........1190.........1200.........1210........ .1220.......
 
   467..470.........480.........490.........500.........510
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Query Sequence  SELPEIITVCDRIAVFCEGRLTQILTNRDDMSEEEIMAWALPQE
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Template Conservation 
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Template Sequence  HRLSTIQ. NADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ
Template Known Secondary structure  S
TTGGG.S
STB
S
S
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   1228.1230.... .....1240.........1250.........1260.........1270
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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