Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	P	R	N	I	N	N	S	L	P	L	Q	P	L	V	P	D	Q	E	N	K	N	K	K	N	E	E	K	S	V	N	P	V	K	I	T	M	G	S	G	L	N	Y	I	E	Q	E	S	L	G	G	K	Y	L	T	H	D	L	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	K	I	A	D	I	S	E	E	I	I	Q	Q	A	I	L	S	A	M	S	I	Y	K	F	S	I	T	D	D	L	M	S	M	A	V	N	E	L	I	K	L	T	K	I	E	N	N	V	D	L	N	K	F	T	T	I	C	T	D	V
Secondary structure
SS confidence
Disorder							?											?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.
Sequence		L	S	P	R	V	T	R	H	N	K	E	K	N	K	R	H	S	T	L	L	K	N	P	L	F	N	F	H
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?											?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1v1h chain A domain 1 Region: 27 - 44 Aligned: 18 Modelled: 18 Confidence: 16.3% Identity: 44% Fold: Triple beta-spiral Superfamily: Fibre shaft of virus attachment proteins Family: Adenovirus Phyre2 PDB 2zif chain B Region: 38 - 75 Aligned: 38 Modelled: 38 Confidence: 14.8% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:putative modification methylase; PDBTitle: crystal structure of ttha0409, putative dna modification2 methylase from thermus thermophilus hb8- complexed with s-3 adenosyl-l-methionine Phyre2 PDB 1o59 chain A domain 2 Region: 10 - 38 Aligned: 29 Modelled: 29 Confidence: 13.7% Identity: 24% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Allantoicase repeat Phyre2 PDB 1sg3 chain A Region: 10 - 38 Aligned: 29 Modelled: 29 Confidence: 11.3% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:allantoicase; PDBTitle: structure of allantoicase Phyre2 PDB 1g60 chain A Region: 38 - 73 Aligned: 36 Modelled: 36 Confidence: 10.4% Identity: 25% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Type II DNA methylase Phyre2 PDB 1n6j chain G Region: 66 - 80 Aligned: 15 Modelled: 15 Confidence: 10.0% Identity: 73% PDB header:transcription/dna Chain: G: PDB Molecule:calcineurin-binding protein cabin 1; PDBTitle: structural basis of sequence-specific recruitment of2 histone deacetylases by myocyte enhancer factor-2 Phyre2 PDB 191l chain A Region: 37 - 142 Aligned: 106 Modelled: 106 Confidence: 8.4% Identity: 15% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1js8 chain A domain 2 Region: 80 - 93 Aligned: 14 Modelled: 14 Confidence: 8.0% Identity: 29% Fold: C-terminal domain of mollusc hemocyanin Superfamily: C-terminal domain of mollusc hemocyanin Family: C-terminal domain of mollusc hemocyanin Phyre2 PDB 1lnl chain A domain 2 Region: 80 - 93 Aligned: 14 Modelled: 14 Confidence: 7.7% Identity: 50% Fold: C-terminal domain of mollusc hemocyanin Superfamily: C-terminal domain of mollusc hemocyanin Family: C-terminal domain of mollusc hemocyanin Phyre2 PDB 1o59 chain A domain 1 Region: 10 - 38 Aligned: 29 Modelled: 28 Confidence: 7.6% Identity: 10% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Allantoicase repeat Phyre2 PDB 1r48 chain A Region: 62 - 70 Aligned: 9 Modelled: 9 Confidence: 6.9% Identity: 67% PDB header:transport protein Chain: A: PDB Molecule:proline/betaine transporter; PDBTitle: solution structure of the c-terminal cytoplasmic domain2 residues 468-497 of escherichia coli protein prop Phyre2 PDB 2i2x chain O Region: 41 - 76 Aligned: 35 Modelled: 36 Confidence: 6.6% Identity: 29% PDB header:transferase Chain: O: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri Phyre2 PDB 1e3h chain A domain 6 Region: 59 - 78 Aligned: 20 Modelled: 20 Confidence: 6.1% Identity: 25% Fold: Ribonuclease PH domain 2-like Superfamily: Ribonuclease PH domain 2-like Family: Ribonuclease PH domain 2-like Phyre2 PDB 1nw6 chain A Region: 38 - 74 Aligned: 37 Modelled: 37 Confidence: 5.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:modification methylase rsri; PDBTitle: structure of the beta class n6-adenine dna methyltransferase rsri2 bound to sinefungin Phyre2 PDB 2iec chain A domain 1 Region: 4 - 63 Aligned: 49 Modelled: 60 Confidence: 5.7% Identity: 22% Fold: MK0786-like Superfamily: MK0786-like Family: MK0786-like Phyre2 PDB 2v6z chain M Region: 69 - 114 Aligned: 46 Modelled: 46 Confidence: 5.4% Identity: 17% PDB header:transferase Chain: M: PDB Molecule:dna polymerase epsilon subunit 2; PDBTitle: solution structure of amino terminal domain of human dna2 polymerase epsilon subunit b Phyre2 1 d1v1ha1 2 c2zifB_ 3 d1o59a2 4 c1sg3A_ 5 d1g60a_ 6 c1n6jG_ 7 d191la_ 8 d1js8a2 9 d1lnla2 10 d1o59a1 11 c1r48A_ 12 c2i2xO_ 13 d1e3ha6 14 c1nw6A_ 15 d2ieca1 16 c2v6zM_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1v1ha1 16.3 44 Fold:Triple beta-spiral Superfamily:Fibre shaft of virus attachment proteins Family:Adenovirus 2 c2zifB_ 14.8 21 PDB header:transferase Chain: B: PDB Molecule:putative modification methylase; PDBTitle: crystal structure of ttha0409, putative dna modification2 methylase from thermus thermophilus hb8- complexed with s-3 adenosyl-l-methionine 3 d1o59a2 13.7 24 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Allantoicase repeat 4 c1sg3A_ 11.3 24 PDB header:hydrolase Chain: A: PDB Molecule:allantoicase; PDBTitle: structure of allantoicase 5 d1g60a_ 10.4 25 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Type II DNA methylase 6 c1n6jG_ 10.0 73 PDB header:transcription/dna Chain: G: PDB Molecule:calcineurin-binding protein cabin 1; PDBTitle: structural basis of sequence-specific recruitment of2 histone deacetylases by myocyte enhancer factor-2 7 d191la_ 8.4 15 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 8 d1js8a2 8.0 29 Fold:C-terminal domain of mollusc hemocyanin Superfamily:C-terminal domain of mollusc hemocyanin Family:C-terminal domain of mollusc hemocyanin 9 d1lnla2 7.7 50 Fold:C-terminal domain of mollusc hemocyanin Superfamily:C-terminal domain of mollusc hemocyanin Family:C-terminal domain of mollusc hemocyanin 10 d1o59a1 7.6 10 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Allantoicase repeat 11 c1r48A_ 6.9 67 PDB header:transport protein Chain: A: PDB Molecule:proline/betaine transporter; PDBTitle: solution structure of the c-terminal cytoplasmic domain2 residues 468-497 of escherichia coli protein prop 12 c2i2xO_ 6.6 29 PDB header:transferase Chain: O: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri 13 d1e3ha6 6.1 25 Fold:Ribonuclease PH domain 2-like Superfamily:Ribonuclease PH domain 2-like Family:Ribonuclease PH domain 2-like 14 c1nw6A_ 5.9 14 PDB header:transferase Chain: A: PDB Molecule:modification methylase rsri; PDBTitle: structure of the beta class n6-adenine dna methyltransferase rsri2 bound to sinefungin 15 d2ieca1 5.7 22 Fold:MK0786-like Superfamily:MK0786-like Family:MK0786-like 16 c2v6zM_ 5.4 17 PDB header:transferase Chain: M: PDB Molecule:dna polymerase epsilon subunit 2; PDBTitle: solution structure of amino terminal domain of human dna2 polymerase epsilon subunit b

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0