Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	E	D	D	Y	K	I	R	R	G	N	A	A	E	L	F	S	G	I	R	H	I	A	I	N	I	L	T	N	E	K	V	F	K	A	G	L	R	R	K	M	R	K	A	A	M	D	R	N	Y	L	A	S	V	L	A	G	S	G
Secondary structure
SS confidence
Disorder		?	?				?	?	?	?	?	?																			?			?	?	?	?	?																						?	?
Disorder confidence
		.	.
Sequence		L	S
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3e3v chain A Region: 14 - 59 Aligned: 46 Modelled: 46 Confidence: 14.6% Identity: 17% PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx from lactobacillus salivarius Phyre2 PDB 3se4 chain B Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 10.1% Identity: 27% PDB header:immune system receptor Chain: B: PDB Molecule:interferon omega-1; PDBTitle: human ifnw-ifnar ternary complex Phyre2 PDB 3oq3 chain A Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 9.9% Identity: 27% PDB header:cytokine/viral protein Chain: A: PDB Molecule:interferon alpha-5; PDBTitle: structural basis of type-i interferon sequestration by a poxvirus2 decoy receptor Phyre2 PDB 1au1 chain A Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 9.6% Identity: 13% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Interferons/interleukin-10 (IL-10) Phyre2 PDB 3piw chain A Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 9.6% Identity: 7% PDB header:cytokine Chain: A: PDB Molecule:type i interferon 2; PDBTitle: zebrafish interferon 2 Phyre2 PDB 1rh2 chain A Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 9.5% Identity: 27% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Interferons/interleukin-10 (IL-10) Phyre2 PDB 1ogl chain A Region: 18 - 61 Aligned: 44 Modelled: 44 Confidence: 9.2% Identity: 18% Fold: all-alpha NTP pyrophosphatases Superfamily: all-alpha NTP pyrophosphatases Family: Type II deoxyuridine triphosphatase Phyre2 PDB 1b5l chain A Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 8.6% Identity: 33% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Interferons/interleukin-10 (IL-10) Phyre2 PDB 3piv chain A Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 8.3% Identity: 20% PDB header:cytokine Chain: A: PDB Molecule:interferon; PDBTitle: zebrafish interferon 1 Phyre2 PDB 1wu3 chain I Region: 45 - 59 Aligned: 15 Modelled: 15 Confidence: 8.0% Identity: 7% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Interferons/interleukin-10 (IL-10) Phyre2 PDB 3fwc chain O Region: 38 - 53 Aligned: 16 Modelled: 16 Confidence: 6.2% Identity: 6% PDB header:cell cycle, transcription Chain: O: PDB Molecule:protein sus1; PDBTitle: sac3:sus1:cdc31 complex Phyre2 PDB 2rrh chain A Region: 50 - 58 Aligned: 9 Modelled: 9 Confidence: 5.7% Identity: 56% PDB header:hormone Chain: A: PDB Molecule:vip peptides; PDBTitle: nmr structure of vasoactive intestinal peptide in methanol Phyre2 1 c3e3vA_ 2 c3se4B_ 3 c3oq3A_ 4 d1au1a_ 5 c3piwA_ 6 d1rh2a_ 7 d1ogla_ 8 d1b5la_ 9 c3pivA_ 10 d1wu3i_ 11 c3fwcO_ 12 c2rrhA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3e3vA_ 14.6 17 PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx from lactobacillus salivarius 2 c3se4B_ 10.1 27 PDB header:immune system receptor Chain: B: PDB Molecule:interferon omega-1; PDBTitle: human ifnw-ifnar ternary complex 3 c3oq3A_ 9.9 27 PDB header:cytokine/viral protein Chain: A: PDB Molecule:interferon alpha-5; PDBTitle: structural basis of type-i interferon sequestration by a poxvirus2 decoy receptor 4 d1au1a_ 9.6 13 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Interferons/interleukin-10 (IL-10) 5 c3piwA_ 9.6 7 PDB header:cytokine Chain: A: PDB Molecule:type i interferon 2; PDBTitle: zebrafish interferon 2 6 d1rh2a_ 9.5 27 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Interferons/interleukin-10 (IL-10) 7 d1ogla_ 9.2 18 Fold:all-alpha NTP pyrophosphatases Superfamily:all-alpha NTP pyrophosphatases Family:Type II deoxyuridine triphosphatase 8 d1b5la_ 8.6 33 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Interferons/interleukin-10 (IL-10) 9 c3pivA_ 8.3 20 PDB header:cytokine Chain: A: PDB Molecule:interferon; PDBTitle: zebrafish interferon 1 10 d1wu3i_ 8.0 7 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Interferons/interleukin-10 (IL-10) 11 c3fwcO_ 6.2 6 PDB header:cell cycle, transcription Chain: O: PDB Molecule:protein sus1; PDBTitle: sac3:sus1:cdc31 complex 12 c2rrhA_ 5.7 56 PDB header:hormone Chain: A: PDB Molecule:vip peptides; PDBTitle: nmr structure of vasoactive intestinal peptide in methanol

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0