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Job DescriptionP31060
Confidence100.00%DateThu Jan 5 11:46:56 GMT 2012
Rank4Aligned Residues458
% Identity25%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   4.....10.... .....20.........30.........40.........50.........60.........70.........80
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Query Sequence  LQILQGTFRLS. . . DTKTLQLPQLTLNAGDSWAFVGSNGSGKSALARALAGELPLLKGERQSQFSHITRLSFEQLQKLVS
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIG
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460.......
 
   81........90.........100.........110.........120.........130. ........140.........
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Query Sequence  DEWQRNNTDMLGPGEDDTGRTTAEIIQDEVKDAPRCMQLAQQFGITALLDR. . . . . . . . . . . RFKYLSTGETRKTLLCQA
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Template Sequence  VVSQEPVLFATTIAENIRYG. . . . . . . REDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARA
Template Known Secondary structure  SS



SS
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SS

TT
TTSTTGGG


SSSS
SS
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   468.470.........480....... ..490.........500.........510.........520.........530.........540
 
   150.........160.........170.........180.........190.........200.........210.........220.........
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Query Sequence  LMSEPDLLILDEPFDGLDVASRQQLAERLASLHQSGITLVLVLNRFDEIPEFVQFAGVLADCTLAETGAKEELLQQALVA
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Template Conservation        
  


    

      
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Template Sequence  LVRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELMREKGIY
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




TS
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   541........550.........560.........570.... .....580......... 590.........600.........610........
 
   230.........240
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Query Sequence  QLAHSEQLEGV. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                          
                                       
Template Sequence  FKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLF
Template Known Secondary structure  T









TTT



SS
STT
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   619620.........630.........640.........650.........660.........670.........680.........690........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation          
                   
   
   
               
 
  
   
           
   
  
Template Sequence  LILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQN
Template Known Secondary structure 

S
S

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   756...760.........770.........780.........790.........800.........810.........820.........830.....
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation          
        
 

 
    
                               
 
 
   

           
Template Sequence  IANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETM
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   836...840.........850.........860.........870.........880.........890.........900.........910.....
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                          
  
                           
        
Template Sequence  YAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYA
Template Known Secondary structure 

TTTT
S
STTTSSSS
S
Template Predicted Secondary structure 





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   916...920.........930.........940.........950.........960.........970.........980.........990.....
 
   241........250.........260.........270 .........280.........290.........300..
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Query Sequence  . . . . . . . . . . . . . . . QLPEPDEPSARHALPANEPRIVLNNGVVSY. . . NDRPILNNLSWQVNPGEHWQIVGPNGAGKSTL
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Template Sequence  KATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTV
Template Known Secondary structure  S




SS
S




TTT





S
GGG

SS


SSS
SSSTT
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   996...1000.........1010.........1020.........1030.........1040.........1050.........1060.........1070.....
 
   303......310.........320.........330.........340.........350.........360.........370.........380..
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Query Sequence  LSLVTGDHPQGYSNDLTLFGRRRGSGETIWDIKKHIGYVSSSLHLDYRVSTTVRNVILSGYFDSIGIYQAVSDRQQKLVQ
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Template Sequence  VQLLERFY. DPMAGSVFLDGKEIKQ. LNVQWLRAQLGIVSQEPIL. . . FDCSIAENIA. . . . . . . . YGDNSRVVSYEEIV
Template Known Secondary structure  TTSS.

SSSSS
BTS.S
TTS
SS


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SSBT........


SS



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   1076...1080... ......1090......... 1100.........1110........ .1120........ .1130.........1140..
 
   383......390.........400 .........410.........420.........430.........440.........450.
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Query Sequence  QWLDILGIDKRTADAPFH. . . . . . . . . . . SLSWGQQRLALIVRALVKHPTLLILDEPLQGLDPLNRQLIRRFVDVLISEG
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Template Sequence  RAAKEANI. HQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKARE. .
Template Known Secondary structure  T
.SSTTTGGG
B
STTS
SS


SSS
SSS

SS..
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   1143......1150 .........1160.........1170.........1180.........1190.........1200.........1210.........
 
   452.......460.........470.........480........
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Query Sequence  ETQLLFVSHHAEDAPACITHRLEFVPDGGLYRYVLTK
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Template Sequence  GRTCIVIAHRLSTIQNA. . DLIVVIQNGKVKEHGTHQ
Template Known Secondary structure  SS

S
TTGGGS
..STB
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   1220.........1230...... ...1240.........1250....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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