|   |
181 | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | V | S | R | A | L | Q | H | D | L | S | D | V | I | G | Q | E | Q | G | K | R | G | L | E | I | T | A | A | G | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G | H | N | L | L | L | I | G | P | P | G | T | G | K | T | M | L | A | S | R | I | N | G | L | L | P | D | L | S | N | E | E | A | L | E | S | A |
Query Conservation |   |
  |   |   |   |   |   |   |   |
|   |   |
|
|   |
|
|   |   |
|
|
|
|
|   |
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |
|   |
|
|
|   |
|   |
|
|
|
|
|
|   |
|
|
|   |
|   |   |
|
|
|   |
|   |   |   |
|   |   |
|   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . |
Template Conservation |   |
|   |   |   |   |
|   |   |   |   |   |
|
|   |
|   |   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |
|
|
|
|
|
|
|
|   |
|
|   |
|
|
|   |   |   | . | . | . | . | . | . | . | . | . | . | . | . |
Template Sequence |   |
I | M | D | H | G | P | P | V | N | W | E | D | I | A | G | V | E | F | A | K | A | T | I | K | E | I | V | V | W | P | M | L | R | P | D | I | F | T | G | L | R | G | P | P | K | G | I | L | L | F | G | P | P | G | T | G | K | T | L | I | G | K | C | I | A | S | Q | S | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
Template Known Secondary structure |   |
T | B |
|
| S |
|
|
|
| G | G | G | S |
| S |
|  |  |  |  |  |  |  |  |  |  | T |  |  |  |  |  |
| T | T | T | S |
| T | T | S | S |
|
| S |  |  |  |  |  | S | S | T | T | S | S |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . |
Template Predicted Secondary structure |   |
 |
|
|
|
|
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . | . | . | . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
391 | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
  |
  |   |
247 | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | |
|
. | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
| . | . |
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | I | L | S | L | V | N | A | E | S | V | Q | K | Q | W | R | Q | R | P | F | R | S | P | H | H | S | A | S | L | T | A | M | V | G | G | G | A | I | P | G | P | G | E | I | S | L | A | H | N | G | V | L | F | L | D | E | L | P | E | F | . |
. |
E | R | R | T | L | D | A | L | R | E | P | I | E | S | G | Q | I | H |
Query Conservation |   |
  |
|   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |
|
|   |   |   |
|   |   |   |
|   |
|
|   |   |   |   |   |
|
|   |
|   |
|
|
|   |
|
|
|
|
|
|
|
|   |   |   | . | . |   |   |   |
|
|   |   |
|
|   |   |
|
|
|
|   |
|   |
Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
Template Conservation |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |
|   |
|
|   |
|
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G | A | T | F | F | S | I | . |
. |
S | A | S | S | L | T | E | G | E | K | M | V | R | A | L | F | A | V | A | R | C | Q | Q | P | A | V | I | F | I | D | E | I | D | S | L | L | S | S | R | R | I | K | T | E | F | L | V | Q | L | D | G | A | E | . |
. |
Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | T |
|  |  |  |  |  | . | . |  | G | G | G | G |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
| S |  |  |  |  |  |  | T | T |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|  |  |
| . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
| . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
459 | 460 | . | . | . | . | . | |
|
. | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | |
|
  |
  |   |
325 | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . |
Predicted Secondary structure |   |
 |
|
|
|
|  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
L | S | R | T | R | A | K | I | T | Y | P | A | R | F | Q | L | V | A | A | M | N | P | S | P | T | G | H | Y | Q | G | N | H | N | R | C | T | P | E | Q | T | L | R | Y | L | N | R | L | S | G | P | F | L | D | R | F | D | L | S | L | E | I | P | L | P | P | P | G | I | L | S | K | T | V | V | P | G | E | S | S | A |
Query Conservation |   |
|   |
|   |
|   |   |   |   |   |
|
|   |
|   |
|
|
|
|   |
|
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|
|
|
|
|   |
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |
Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
Template Conservation |   |
. | . | . | . | . | . | . | . | . | . | . |   |   |
|   |   |
|   |
|
|
|   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   | . | . | . | . | . | . | . | . | . | . |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
D | R | I | L | V | V | G | A | T | N | R | P | Q | E | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
I | D | E | A | A | R | R | R | L | V | K | R | L | Y | I | P | L | P | E | A | S | A | R | K | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |  |  |  |  | S |
| G | G | G | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |  |  |  | S |
|  |  |  |  |
|
|
|
|
|  |  |  |  |  | . | . | . | . | . | . | . | . | . | . |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |
|
|
|  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  | . | . | . | . | . | . | . | . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
|
|
|
|
537 | . | . | 540 | . | . | . | . | . | . | . | . | . | 550 | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | |
|
|
|
|
|
|
|
|
|
  |
  |   |
405 | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
| . | . | . | . | . |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
Query Sequence |   |
T | V | K | Q | R | V | M | A | A | R | E | R | Q | F | K | R | Q | N | K | L | N | A | W | L | D | S | P | E | I | R | Q | F | C | K | L | E | S | E | D | A | M | W | L | E | G | T | L | I | H | L | G | L | S | I | R | A | W | Q | R | L | L | K | V | A | R | T | I | A | D | I | D | Q | S | D | I | . |
. |
. |
. |
. |
Query Conservation |   |
  |   |   |   |   |
|   |   |
|
|   |   |   |   |   |
|   |   |   |   |
|   |   |
|   |   |   |   |
|   |   |   |
|   |
|   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |
|
|   |
|   |   |   |   |
|
|
|
|
|
|
|
|
|
|
|   |
|   |   |   | . | . | . | . | . |
Alig confidence |   |
. | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
Template Conservation |   |
. | . | . | . | . | . | . | . | . | . |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|   |   |
|   | . | . | . | . | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
|
|   |   |
|   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
Q | I | V | I | N | L | M | S | K | E | Q | C | C | L | S | E | E | E | I | E | Q | I | V | Q | Q | S | D | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
A | F | S | G | A | D | M | T | Q | L | C | R | E | A | S | L | G | P | I | R | S | L | Q | T | A | A | T | I | T | P |
Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  | T | T | S |
| B |
|
|
|  |  |  |  |  |  |  |  |  |  | T | T | . | . | . | . | . | . | . | . | . | . | . | . | . | T |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
| G |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
|
|
|
575 | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600 | . | |
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . |
  |
  |   |
|
|
|
|
|
480 | . | . | . | . | . | . | . | . | . | 490 |
Predicted Secondary structure |   |
. | . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
. |
. |
. |
. |
. |
I | T | R | Q | H | L | Q | E | A | V | S |
Query Conservation |   |
. | . | . | . | . |
|   |   |   |
|
|   |
|
|
|   |
Alig confidence |   |
. | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |
|   |   |   |
|
|   |   |
|
|   |
Template Sequence |   |
D | Q | V | R | P | I | A | Y | I | D | F | E | N | A | F | R |
Template Known Secondary structure |   |
G | G | S |
|
| B |
|  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
634 | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . |
  |