Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	V	Q	K	N	V	I	K	G	I	L	A	G	T	F	A	L	M	L	S	G	C	V	T	V	P	D	A	I	K	G	S	S	P	T	P	Q	Q	D	L	V	R	V	M	S	A	P	Q	L	Y	V	G	Q	E	A	R	F	G	G
Secondary structure
SS confidence
Disorder		?	?	?	?																	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?						?	?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	V	V	A	V	Q	N	Q	Q	G	K	T	R	L	E	I	A	T	V	P	L	D	S	G	A	R	P	T	L	G	E	P	S	R	G	R	I	Y	A	D	V	N	G	F	L	D	P	V	D	F	R	G	Q	L	V	T	V	V	G	P
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	T	G	A	V	D	G	K	I	G	N	T	P	Y	K	F	M	V	M	Q	V	T	G	Y	K	R	W	H	L	T	Q	Q	V	I	M	P	P	Q	P	I	D	P	W	F	Y	G	G	R	G	W	P	Y	G	Y	G	G	W	G	W	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?				?	?																					?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.
Sequence		N	P	G	P	A	R	V	Q	T	V	V	T	E
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1j6q chain A Region: 42 - 123 Aligned: 70 Modelled: 71 Confidence: 82.1% Identity: 24% PDB header:chaperone Chain: A: PDB Molecule:cytochrome c maturation protein e; PDBTitle: solution structure and characterization of the heme2 chaperone ccme Phyre2 PDB 1j6q chain A Region: 42 - 123 Aligned: 70 Modelled: 71 Confidence: 82.1% Identity: 24% Fold: OB-fold Superfamily: Heme chaperone CcmE Family: Heme chaperone CcmE Phyre2 PDB 1sr3 chain A Region: 46 - 122 Aligned: 64 Modelled: 77 Confidence: 45.5% Identity: 30% Fold: OB-fold Superfamily: Heme chaperone CcmE Family: Heme chaperone CcmE Phyre2 PDB 2kct chain A Region: 45 - 122 Aligned: 67 Modelled: 78 Confidence: 45.1% Identity: 22% PDB header:chaperone Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccme; PDBTitle: solution nmr structure of the ob-fold domain of heme2 chaperone ccme from desulfovibrio vulgaris. northeast3 structural genomics target dvr115g. Phyre2 PDB 2r9q chain D Region: 72 - 107 Aligned: 36 Modelled: 36 Confidence: 39.1% Identity: 31% PDB header:hydrolase Chain: D: PDB Molecule:2'-deoxycytidine 5'-triphosphate deaminase; PDBTitle: crystal structure of 2'-deoxycytidine 5'-triphosphate deaminase from2 agrobacterium tumefaciens Phyre2 PDB 2wkd chain A Region: 99 - 140 Aligned: 32 Modelled: 42 Confidence: 38.6% Identity: 31% PDB header:dna binding protein Chain: A: PDB Molecule:orf34p2; PDBTitle: crystal structure of a double ile-to-met mutant of protein2 orf34 from lactococcus phage p2 Phyre2 PDB 2dzl chain A Region: 1 - 25 Aligned: 25 Modelled: 25 Confidence: 27.6% Identity: 16% PDB header:structural genomics unknown function Chain: A: PDB Molecule:protein fam100b; PDBTitle: solution structure of the uba domain in human protein2 fam100b Phyre2 PDB 1n9w chain A domain 1 Region: 46 - 76 Aligned: 31 Modelled: 31 Confidence: 27.4% Identity: 19% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Anticodon-binding domain Phyre2 PDB 2wp8 chain J Region: 60 - 125 Aligned: 65 Modelled: 66 Confidence: 25.4% Identity: 23% PDB header:hydrolase Chain: J: PDB Molecule:exosome complex exonuclease dis3; PDBTitle: yeast rrp44 nuclease Phyre2 PDB 2z14 chain A Region: 50 - 121 Aligned: 72 Modelled: 72 Confidence: 24.6% Identity: 17% PDB header:signaling protein Chain: A: PDB Molecule:ef-hand domain-containing family member c2; PDBTitle: crystal structure of the n-terminal duf1126 in human ef-2 hand domain containing 2 protein Phyre2 PDB 3h43 chain F Region: 92 - 117 Aligned: 26 Modelled: 26 Confidence: 22.1% Identity: 23% PDB header:hydrolase Chain: F: PDB Molecule:proteasome-activating nucleotidase; PDBTitle: n-terminal domain of the proteasome-activating nucleotidase2 of methanocaldococcus jannaschii Phyre2 PDB 2ijr chain A domain 1 Region: 9 - 41 Aligned: 33 Modelled: 33 Confidence: 21.1% Identity: 21% Fold: Api92-like Superfamily: Api92-like Family: Api92-like Phyre2 PDB 1wyd chain B Region: 49 - 146 Aligned: 78 Modelled: 84 Confidence: 20.6% Identity: 18% PDB header:ligase Chain: B: PDB Molecule:hypothetical aspartyl-trna synthetase; PDBTitle: crystal structure of aspartyl-trna synthetase from sulfolobus tokodaii Phyre2 PDB 2vnu chain D domain 1 Region: 96 - 125 Aligned: 30 Modelled: 30 Confidence: 20.3% Identity: 23% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 1t3t chain A domain 6 Region: 91 - 129 Aligned: 39 Modelled: 39 Confidence: 19.5% Identity: 21% Fold: PurM C-terminal domain-like Superfamily: PurM C-terminal domain-like Family: PurM C-terminal domain-like Phyre2 PDB 2pi2 chain E domain 1 Region: 49 - 123 Aligned: 57 Modelled: 75 Confidence: 19.4% Identity: 19% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Single strand DNA-binding domain, SSB Phyre2 PDB 2wg6 chain L Region: 92 - 117 Aligned: 26 Modelled: 26 Confidence: 19.3% Identity: 8% PDB header:transcription,hydrolase Chain: L: PDB Molecule:general control protein gcn4, PDBTitle: proteasome-activating nucleotidase (pan) n-domain (57-134)2 from archaeoglobus fulgidus fused to gcn4, p61a mutant Phyre2 PDB 2jwy chain A Region: 45 - 130 Aligned: 86 Modelled: 86 Confidence: 18.6% Identity: 15% PDB header:lipoprotein Chain: A: PDB Molecule:uncharacterized lipoprotein yaji; PDBTitle: solution nmr structure of uncharacterized lipoprotein yaji from2 escherichia coli. northeast structural genomics target er540 Phyre2 PDB 1l0w chain A domain 1 Region: 49 - 76 Aligned: 28 Modelled: 28 Confidence: 16.5% Identity: 25% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Anticodon-binding domain Phyre2 PDB 2zau chain B Region: 90 - 129 Aligned: 40 Modelled: 40 Confidence: 13.2% Identity: 8% PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase; PDBTitle: crystal structure of an n-terminally truncated2 selenophosphate synthetase from aquifex aeolicus Phyre2 1 c1j6qA_ 2 d1j6qa_ 3 d1sr3a_ 4 c2kctA_ 5 c2r9qD_ 6 c2wkdA_ 7 c2dzlA_ 8 d1n9wa1 9 c2wp8J_ 10 c2z14A_ 11 c3h43F_ 12 d2ijra1 13 c1wydB_ 14 d2vnud1 15 d1t3ta6 16 d2pi2e1 17 c2wg6L_ 18 c2jwyA_ 19 d1l0wa1 20 c2zauB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1j6qA_ 82.1 24 PDB header:chaperone Chain: A: PDB Molecule:cytochrome c maturation protein e; PDBTitle: solution structure and characterization of the heme2 chaperone ccme 2 d1j6qa_ 82.1 24 Fold:OB-fold Superfamily:Heme chaperone CcmE Family:Heme chaperone CcmE 3 d1sr3a_ 45.5 30 Fold:OB-fold Superfamily:Heme chaperone CcmE Family:Heme chaperone CcmE 4 c2kctA_ 45.1 22 PDB header:chaperone Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccme; PDBTitle: solution nmr structure of the ob-fold domain of heme2 chaperone ccme from desulfovibrio vulgaris. northeast3 structural genomics target dvr115g. 5 c2r9qD_ 39.1 31 PDB header:hydrolase Chain: D: PDB Molecule:2'-deoxycytidine 5'-triphosphate deaminase; PDBTitle: crystal structure of 2'-deoxycytidine 5'-triphosphate deaminase from2 agrobacterium tumefaciens 6 c2wkdA_ 38.6 31 PDB header:dna binding protein Chain: A: PDB Molecule:orf34p2; PDBTitle: crystal structure of a double ile-to-met mutant of protein2 orf34 from lactococcus phage p2 7 c2dzlA_ 27.6 16 PDB header:structural genomics unknown function Chain: A: PDB Molecule:protein fam100b; PDBTitle: solution structure of the uba domain in human protein2 fam100b 8 d1n9wa1 27.4 19 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Anticodon-binding domain 9 c2wp8J_ 25.4 23 PDB header:hydrolase Chain: J: PDB Molecule:exosome complex exonuclease dis3; PDBTitle: yeast rrp44 nuclease 10 c2z14A_ 24.6 17 PDB header:signaling protein Chain: A: PDB Molecule:ef-hand domain-containing family member c2; PDBTitle: crystal structure of the n-terminal duf1126 in human ef-2 hand domain containing 2 protein 11 c3h43F_ 22.1 23 PDB header:hydrolase Chain: F: PDB Molecule:proteasome-activating nucleotidase; PDBTitle: n-terminal domain of the proteasome-activating nucleotidase2 of methanocaldococcus jannaschii 12 d2ijra1 21.1 21 Fold:Api92-like Superfamily:Api92-like Family:Api92-like 13 c1wydB_ 20.6 18 PDB header:ligase Chain: B: PDB Molecule:hypothetical aspartyl-trna synthetase; PDBTitle: crystal structure of aspartyl-trna synthetase from sulfolobus tokodaii 14 d2vnud1 20.3 23 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 15 d1t3ta6 19.5 21 Fold:PurM C-terminal domain-like Superfamily:PurM C-terminal domain-like Family:PurM C-terminal domain-like 16 d2pi2e1 19.4 19 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Single strand DNA-binding domain, SSB 17 c2wg6L_ 19.3 8 PDB header:transcription,hydrolase Chain: L: PDB Molecule:general control protein gcn4, PDBTitle: proteasome-activating nucleotidase (pan) n-domain (57-134)2 from archaeoglobus fulgidus fused to gcn4, p61a mutant 18 c2jwyA_ 18.6 15 PDB header:lipoprotein Chain: A: PDB Molecule:uncharacterized lipoprotein yaji; PDBTitle: solution nmr structure of uncharacterized lipoprotein yaji from2 escherichia coli. northeast structural genomics target er540 19 d1l0wa1 16.5 25 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Anticodon-binding domain 20 c2zauB_ 13.2 8 PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase; PDBTitle: crystal structure of an n-terminally truncated2 selenophosphate synthetase from aquifex aeolicus 21 c1yrlD_ not modelled 12.2 24 PDB header:oxidoreductase Chain: D: PDB Molecule:ketol-acid reductoisomerase; PDBTitle: escherichia coli ketol-acid reductoisomerase 22 c2p39A_ not modelled 11.5 16 PDB header:signaling protein Chain: A: PDB Molecule:fibroblast growth factor 23; PDBTitle: crystal structure of human fgf23 23 c1pwaA_ not modelled 11.4 24 PDB header:hormone/growth factor Chain: A: PDB Molecule:fibroblast growth factor-19; PDBTitle: crystal structure of fibroblast growth factor 19 24 d1pwaa_ not modelled 11.4 24 Fold:beta-Trefoil Superfamily:Cytokine Family:Fibroblast growth factors (FGF) 25 c2jn4A_ not modelled 11.2 39 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein fixu, nift; PDBTitle: solution nmr structure of protein rp4601 from2 rhodopseudomonas palustris. northeast structural genomics3 consortium target rpt2; ontario center for structural4 proteomics target rp4601. 26 d2jn4a1 not modelled 11.2 39 Fold:NifT/FixU barrel-like Superfamily:NifT/FixU-like Family:NifT/FixU 27 c2zodB_ not modelled 11.1 8 PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase; PDBTitle: crystal structure of selenophosphate synthetase from2 aquifex aeolicus 28 c2pqaB_ not modelled 10.9 10 PDB header:replication Chain: B: PDB Molecule:replication protein a 14 kda subunit; PDBTitle: crystal structure of full-length human rpa 14/32 heterodimer 29 d1so0a_ not modelled 10.6 23 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Aldose 1-epimerase (mutarotase) 30 c1b8aB_ not modelled 10.4 24 PDB header:ligase Chain: B: PDB Molecule:protein (aspartyl-trna synthetase); PDBTitle: aspartyl-trna synthetase 31 c1vqwB_ not modelled 8.7 16 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein with similarity to flavin-containing PDBTitle: crystal structure of a protein with similarity to flavin-2 containing monooxygenases and to mammalian dimethylalanine3 monooxygenases 32 d1ps9a2 not modelled 8.5 15 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:C-terminal domain of adrenodoxin reductase-like 33 c2pi2A_ not modelled 7.1 11 PDB header:replication, dna binding protein Chain: A: PDB Molecule:replication protein a 32 kda subunit; PDBTitle: full-length replication protein a subunits rpa14 and rpa32 34 d2zoda2 not modelled 6.9 5 Fold:PurM C-terminal domain-like Superfamily:PurM C-terminal domain-like Family:PurM C-terminal domain-like 35 d1c0aa1 not modelled 6.2 18 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Anticodon-binding domain 36 d1b33n_ not modelled 6.1 63 Fold:Allophycocyanin linker chain (domain) Superfamily:Allophycocyanin linker chain (domain) Family:Allophycocyanin linker chain (domain) 37 d2z1ea2 not modelled 6.1 17 Fold:PurM C-terminal domain-like Superfamily:PurM C-terminal domain-like Family:PurM C-terminal domain-like 38 c3ls1A_ not modelled 6.0 16 PDB header:photosynthesis Chain: A: PDB Molecule:sll1638 protein; PDBTitle: crystal structure of cyanobacterial psbq from synechocystis2 sp. pcc 6803 complexed with zn2+ 39 d1yloa1 not modelled 5.7 13 Fold:Domain of alpha and beta subunits of F1 ATP synthase-like Superfamily:Aminopeptidase/glucanase lid domain Family:Aminopeptidase/glucanase lid domain 40 d1krta_ not modelled 5.6 6 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Anticodon-binding domain 41 d1geha2 not modelled 5.6 8 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 42 d2gycb1 not modelled 5.4 25 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Translation proteins Family:Ribosomal protein L3 43 c2esyA_ not modelled 5.2 36 PDB header:lipid binding protein Chain: A: PDB Molecule:lung surfactant protein c; PDBTitle: structure and influence on stability and activity of the n-2 terminal propetide part of lung surfactant protein c 44 c3m9bK_ not modelled 5.1 20 PDB header:chaperone Chain: K: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain and the2 inter domain of the mycobacterium tuberculosis proteasomal atpase mpa 45 c2pxgA_ not modelled 5.1 14 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein; PDBTitle: nmr solution structure of omla 46 d1lura_ not modelled 5.0 18 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Aldose 1-epimerase (mutarotase)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0