Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	D	V	T	L	L	I	L	L	G	L	A	A	L	G	F	I	S	H	N	T	T	V	A	V	S	I	L	V	L	I	I	V	R	V	T	P	L	S	T	F	F	P	W	I	E	K	Q	G	L	S	I	G	I	I	I	L	T	I
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	M	A	P	I	A	S	G	T	L	P	P	S	T	L	I	H	S	F	L	N	W	K	S	L	V	A	I	A	V	G	V	I	V	S	W	L	G	G	R	G	V	T	L	M	G	S	Q	P	Q	L	V	A	G	L	L	V	G	T
Secondary structure
SS confidence
Disorder										?		?																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.
Sequence		V	L	G	V	A	L	F	R	G	V	P	V	G	P	L	I	A	A	G	L	V	S	L	I	V	G	K	Q
Secondary structure
SS confidence
Disorder																										?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1wu0 chain A Region: 84 - 147 Aligned: 61 Modelled: 61 Confidence: 57.6% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:atp synthase c chain; PDBTitle: solution structure of subunit c of f1fo-atp synthase from2 the thermophilic bacillus ps3 Phyre2 PDB 2x2v chain G Region: 84 - 126 Aligned: 43 Modelled: 43 Confidence: 14.9% Identity: 26% PDB header:membrane protein Chain: G: PDB Molecule:atp synthase subunit c; PDBTitle: structural basis of a novel proton-coordination type in an2 f1fo-atp synthase rotor ring Phyre2 PDB 3dd7 chain A Region: 35 - 85 Aligned: 51 Modelled: 51 Confidence: 13.0% Identity: 12% PDB header:ribosome inhibitor Chain: A: PDB Molecule:death on curing protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd Phyre2 PDB 2l2t chain A Region: 134 - 141 Aligned: 8 Modelled: 8 Confidence: 10.9% Identity: 75% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain Phyre2 PDB 1kve chain A Region: 84 - 102 Aligned: 19 Modelled: 19 Confidence: 9.3% Identity: 37% PDB header:toxin Chain: A: PDB Molecule:smk toxin; PDBTitle: killer toxin from halotolerant yeast Phyre2 PDB 2w5j chain M Region: 85 - 126 Aligned: 42 Modelled: 42 Confidence: 7.9% Identity: 24% PDB header:hydrolase Chain: M: PDB Molecule:atp synthase c chain, chloroplastic; PDBTitle: structure of the c14-rotor ring of the proton translocating2 chloroplast atp synthase Phyre2 PDB 1c99 chain A Region: 84 - 145 Aligned: 59 Modelled: 62 Confidence: 7.0% Identity: 29% Fold: Transmembrane helix hairpin Superfamily: F1F0 ATP synthase subunit C Family: F1F0 ATP synthase subunit C Phyre2 PDB 2kjf chain A Region: 115 - 133 Aligned: 17 Modelled: 19 Confidence: 6.7% Identity: 47% PDB header:antimicrobial protein Chain: A: PDB Molecule:carnocyclin-a; PDBTitle: the solution structure of the circular bacteriocin2 carnocyclin a (ccla) Phyre2 1 c1wu0A_ 2 c2x2vG_ 3 c3dd7A_ 4 c2l2tA_ 5 c1kveA_ 6 c2w5jM_ 7 d1c99a_ 8 c2kjfA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1wu0A_ 57.6 25 PDB header:hydrolase Chain: A: PDB Molecule:atp synthase c chain; PDBTitle: solution structure of subunit c of f1fo-atp synthase from2 the thermophilic bacillus ps3 2 c2x2vG_ 14.9 26 PDB header:membrane protein Chain: G: PDB Molecule:atp synthase subunit c; PDBTitle: structural basis of a novel proton-coordination type in an2 f1fo-atp synthase rotor ring 3 c3dd7A_ 13.0 12 PDB header:ribosome inhibitor Chain: A: PDB Molecule:death on curing protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd 4 c2l2tA_ 10.9 75 PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain 5 c1kveA_ 9.3 37 PDB header:toxin Chain: A: PDB Molecule:smk toxin; PDBTitle: killer toxin from halotolerant yeast 6 c2w5jM_ 7.9 24 PDB header:hydrolase Chain: M: PDB Molecule:atp synthase c chain, chloroplastic; PDBTitle: structure of the c14-rotor ring of the proton translocating2 chloroplast atp synthase 7 d1c99a_ 7.0 29 Fold:Transmembrane helix hairpin Superfamily:F1F0 ATP synthase subunit C Family:F1F0 ATP synthase subunit C 8 c2kjfA_ 6.7 47 PDB header:antimicrobial protein Chain: A: PDB Molecule:carnocyclin-a; PDBTitle: the solution structure of the circular bacteriocin2 carnocyclin a (ccla)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0