Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP39357
DateThu Jan 5 11:59:47 GMT 2012
Unique Job ID3822ce7586a8e2f0

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2vofA_
Top template information
PDB header:apoptosis
Chain: A: PDB Molecule:bcl-2-related protein a1;
PDBTitle: structure of mouse a1 bound to the puma bh3-domain
Confidence and coverage
Confidence: 17.3% Coverage: 9%
39 residues ( 9% of your sequence) have been modelled with 17.3% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MPLIIVVAGIALLLLLTIKIKLNTFVSLIIVSIAVAIASGMDLSKVVTSVESGLGGTLGH
Secondary structure 






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   .........70.........80.........90.........100.........110.........120
Sequence  IGLIFGFGVMLGRLLADAGGAQRIALTMLNYFGKNKLDWAVVCSAFIVGIALFFEVGLIL
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   .........130.........140.........150.........160.........170.........180
Sequence  LVPILFAIAREAKISPMFMCVPMLSGLLVAHGFLPPHPGPTVIAREYGADVGLVLIYGII
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   .........190.........200.........210.........220.........230.........240
Sequence  VGIPTFILCGPVLNKFCQRIIPDAFKKEGNIASLGATRRFSESEMPGFGISFLTAMLPVI
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   .........250.........260.........270.........280.........290.........300
Sequence  LMAVVTIIQMTHAKSAADSGLFYNVILFLGNSTIAMLISLLFAIYTMGLGRGKTIPDLMD
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   .........310.........320.........330.........340.........350.........360
Sequence  SCGKAIAGIAGLLLIIGGGGAFKQVLIDSGVGQYISTLVSGMDINPILMAWGVAAFLRIC
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   .........370.........380.........390.........400.........410.........420
Sequence  LGSATVAAISTAGLVIPLLAVHPNTNLALITLATGAGSCICSHVNDASFWMIKDFFGLTT
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   .........430.........440.........
Sequence  KETLLSWTLMSTLLSISGLIFILLASLVL
Secondary structure 

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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2vof chain A

3D model

Region: 57 - 95
Aligned: 39
Modelled: 38
Confidence: 17.3%
Identity: 23%
PDB header:apoptosis
Chain: A: PDB Molecule:bcl-2-related protein a1;
PDBTitle: structure of mouse a1 bound to the puma bh3-domain

Phyre2

PDB 2bbj chain B

3D model

Region: 159 - 201
Aligned: 40
Modelled: 43
Confidence: 9.2%
Identity: 18%
PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter

Phyre2

PDB 2knc chain A

3D model

Region: 174 - 214
Aligned: 41
Modelled: 41
Confidence: 7.2%
Identity: 10%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Phyre2

PDB 3b9y chain A

3D model

Region: 104 - 239
Aligned: 127
Modelled: 136
Confidence: 6.1%
Identity: 12%
PDB header:transport protein
Chain: A: PDB Molecule:ammonium transporter family rh-like protein;
PDBTitle: crystal structure of the nitrosomonas europaea rh protein

Phyre2

PDB 3qbr chain A

3D model

Region: 57 - 95
Aligned: 39
Modelled: 39
Confidence: 5.5%
Identity: 26%
PDB header:apoptosis
Chain: A: PDB Molecule:sjchgc06286 protein;
PDBTitle: bakbh3 in complex with sja

Phyre2

PDB 1fft chain B domain 2

3D model

Region: 171 - 220
Aligned: 50
Modelled: 50
Confidence: 5.3%
Identity: 4%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 1b9u chain A

3D model

Region: 3 - 29
Aligned: 27
Modelled: 27
Confidence: 5.2%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:protein (atp synthase);
PDBTitle: membrane domain of the subunit b of the e.coli atp synthase

Phyre2
1

c2vofA_
2

c2bbjB_
3

c2kncA_
4

c3b9yA_
5

c3qbrA_
6

d1fftb2
7

c1b9uA_



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2vofA_



17.3 23 PDB header:apoptosis
Chain: A: PDB Molecule:bcl-2-related protein a1;
PDBTitle: structure of mouse a1 bound to the puma bh3-domain
2c2bbjB_



9.2 18 PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter
3c2kncA_



7.2 10 PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex
4c3b9yA_



6.1 12 PDB header:transport protein
Chain: A: PDB Molecule:ammonium transporter family rh-like protein;
PDBTitle: crystal structure of the nitrosomonas europaea rh protein
5c3qbrA_



5.5 26 PDB header:apoptosis
Chain: A: PDB Molecule:sjchgc06286 protein;
PDBTitle: bakbh3 in complex with sja
6d1fftb2



5.3 4 Fold:Transmembrane helix hairpin
Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region
Family:Cytochrome c oxidase subunit II-like, transmembrane region
7c1b9uA_



5.2 15 PDB header:hydrolase
Chain: A: PDB Molecule:protein (atp synthase);
PDBTitle: membrane domain of the subunit b of the e.coli atp synthase

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0