Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	W	D	V	I	D	L	S	R	W	Q	F	A	L	T	A	L	Y	H	F	L	F	V	P	L	T	L	G	L	I	F	L	L	A	I	M	E	T	I	Y	V	V	T	G	K	T	I	Y	R	D	M	T	R	F	W	G	K	L	F	G
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	N	F	A	L	G	V	A	T	G	L	T	M	E	F	Q	F	G	T	N	W	S	F	Y	S	N	Y	V	G	D	I	F	G	A	P	L	A	M	E	A	L	M	A	F	F	L	E	S	T	F	V	G	L	F	F	F	G	W	Q	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	N	K	Y	Q	H	L	L	V	T	W	L	V	A	F	G	S	N	L	S	A	L	W	I	L	N	A	N	G	W	M	Q	Y	P	T	G	A	H	F	D	I	D	T	L	R	M	E	M	T	S	F	S	E	L	V	F	N	P	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	V	K	F	V	H	T	V	M	A	G	Y	V	T	G	A	M	F	I	M	A	I	S	A	W	Y	L	L	R	G	R	E	R	N	V	A	L	R	S	F	A	I	G	S	V	F	G	T	L	A	I	I	G	T	L	Q	L	G	D	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	A	Y	E	V	A	Q	V	Q	P	V	K	L	A	A	M	E	G	E	W	Q	T	E	P	A	P	A	P	F	H	V	V	A	W	P	E	Q	D	Q	E	R	N	A	F	A	L	K	I	P	A	L	L	G	I	L	A	T	H	S	L
Secondary structure
SS confidence
Disorder																		?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	K	P	V	P	G	L	K	N	L	M	A	E	T	Y	P	R	L	Q	R	G	R	M	A	W	L	L	M	Q	E	I	S	Q	G	N	R	E	P	H	V	L	Q	A	F	R	G	L	E	G	D	L	G	Y	G	M	L	L	S	R	Y
Secondary structure
SS confidence
Disorder																						?	?	?								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	P	D	M	N	H	V	T	A	A	Q	Y	Q	A	A	M	R	G	A	I	P	Q	V	A	P	V	F	W	S	F	R	I	M	V	G	C	G	S	L	L	L	L	V	M	L	I	A	L	V	Q	T	L	R	G	K	I	D	Q	H	R
Secondary structure
SS confidence
Disorder																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		W	V	L	K	M	A	L	W	S	L	P	L	P	W	I	A	I	E	A	G	W	F	M	T	E	F	G	R	Q	P	W	A	I	Q	D	I	L	P	T	Y	S	A	H	S	A	L	T	T	G	Q	L	A	F	S	L	I	M	I	V	G
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.
Sequence		L	Y	T	L	F	L	I	A	E	V	Y	L	M	Q	K	Y	A	R	L	G	P	S	A	M	Q	S	E	Q	P	T	Q	Q	Q	G
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3mk7 chain K Region: 22 - 213 Aligned: 188 Modelled: 192 Confidence: 96.7% Identity: 14% PDB header:oxidoreductase Chain: K: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit n; PDBTitle: the structure of cbb3 cytochrome oxidase Phyre2 PDB 1fft chain A Region: 22 - 213 Aligned: 176 Modelled: 178 Confidence: 91.8% Identity: 18% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 1fft chain F Region: 22 - 213 Aligned: 176 Modelled: 178 Confidence: 91.8% Identity: 18% PDB header:oxidoreductase Chain: F: PDB Molecule:ubiquinol oxidase; PDBTitle: the structure of ubiquinol oxidase from escherichia coli Phyre2 PDB 1ar1 chain A Region: 22 - 213 Aligned: 175 Modelled: 177 Confidence: 79.7% Identity: 17% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 3dtu chain A domain 1 Region: 20 - 213 Aligned: 177 Modelled: 179 Confidence: 76.8% Identity: 18% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 1m56 chain G Region: 20 - 213 Aligned: 177 Modelled: 179 Confidence: 76.1% Identity: 18% PDB header:oxidoreductase Chain: G: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobactor2 sphaeroides (wild type) Phyre2 PDB 1v54 chain A Region: 22 - 213 Aligned: 175 Modelled: 177 Confidence: 75.7% Identity: 15% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 3o0r chain B Region: 22 - 203 Aligned: 175 Modelled: 176 Confidence: 40.0% Identity: 10% PDB header:immune system/oxidoreductase Chain: B: PDB Molecule:nitric oxide reductase subunit b; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment Phyre2 PDB 1xme chain A domain 1 Region: 10 - 250 Aligned: 230 Modelled: 241 Confidence: 31.0% Identity: 19% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 3kp9 chain A Region: 91 - 144 Aligned: 51 Modelled: 54 Confidence: 29.1% Identity: 16% PDB header:blood coagulation,oxidoreductase Chain: A: PDB Molecule:vkorc1/thioredoxin domain protein; PDBTitle: structure of a bacterial homolog of vitamin k epoxide reductase Phyre2 PDB 2bbj chain B Region: 50 - 120 Aligned: 54 Modelled: 71 Confidence: 17.1% Identity: 17% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 3lw5 chain 2 Region: 424 - 512 Aligned: 77 Modelled: 89 Confidence: 16.2% Identity: 21% PDB header:photosynthesis Chain: 2: PDB Molecule:type ii chlorophyll a/b binding protein from photosystem i; PDB Fragment:residues 81-246; PDBTitle: improved model of plant photosystem i Phyre2 PDB 2p3h chain A domain 1 Region: 437 - 450 Aligned: 14 Modelled: 14 Confidence: 14.1% Identity: 7% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: CorC/HlyC domain-like Phyre2 PDB 2r2z chain A domain 1 Region: 437 - 450 Aligned: 14 Modelled: 12 Confidence: 13.5% Identity: 36% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: CorC/HlyC domain-like Phyre2 PDB 3ded chain A domain 1 Region: 437 - 450 Aligned: 14 Modelled: 14 Confidence: 11.5% Identity: 36% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: CorC/HlyC domain-like Phyre2 PDB 2o3g chain A domain 1 Region: 437 - 450 Aligned: 14 Modelled: 14 Confidence: 11.0% Identity: 29% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: CorC/HlyC domain-like Phyre2 PDB 3fh6 chain F Region: 386 - 507 Aligned: 121 Modelled: 122 Confidence: 10.3% Identity: 8% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 3ded chain B Region: 437 - 450 Aligned: 14 Modelled: 14 Confidence: 9.5% Identity: 36% PDB header:membrane protein Chain: B: PDB Molecule:probable hemolysin; PDBTitle: c-terminal domain of probable hemolysin from chromobacterium violaceum Phyre2 PDB 1hgv chain A Region: 176 - 210 Aligned: 35 Modelled: 35 Confidence: 9.1% Identity: 23% PDB header:virus Chain: A: PDB Molecule:ph75 inovirus major coat protein; PDBTitle: filamentous bacteriophage ph75 Phyre2 PDB 2a65 chain A domain 1 Region: 4 - 126 Aligned: 110 Modelled: 123 Confidence: 8.2% Identity: 15% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 1 c3mk7K_ 2 d1ffta_ 3 c1fftF_ 4 d1ar1a_ 5 d3dtua1 6 c1m56G_ 7 d1v54a_ 8 c3o0rB_ 9 d1xmea1 10 c3kp9A_ 11 c2bbjB_ 12 c3lw52_ 13 d2p3ha1 14 d2r2za1 15 d3deda1 16 d2o3ga1 17 c3fh6F_ 18 c3dedB_ 19 c1hgvA_ 20 d2a65a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3mk7K_ 96.7 14 PDB header:oxidoreductase Chain: K: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit n; PDBTitle: the structure of cbb3 cytochrome oxidase 2 d1ffta_ 91.8 18 Fold:Cytochrome c oxidase subunit I-like Superfamily:Cytochrome c oxidase subunit I-like Family:Cytochrome c oxidase subunit I-like 3 c1fftF_ 91.8 18 PDB header:oxidoreductase Chain: F: PDB Molecule:ubiquinol oxidase; PDBTitle: the structure of ubiquinol oxidase from escherichia coli 4 d1ar1a_ 79.7 17 Fold:Cytochrome c oxidase subunit I-like Superfamily:Cytochrome c oxidase subunit I-like Family:Cytochrome c oxidase subunit I-like 5 d3dtua1 76.8 18 Fold:Cytochrome c oxidase subunit I-like Superfamily:Cytochrome c oxidase subunit I-like Family:Cytochrome c oxidase subunit I-like 6 c1m56G_ 76.1 18 PDB header:oxidoreductase Chain: G: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobactor2 sphaeroides (wild type) 7 d1v54a_ 75.7 15 Fold:Cytochrome c oxidase subunit I-like Superfamily:Cytochrome c oxidase subunit I-like Family:Cytochrome c oxidase subunit I-like 8 c3o0rB_ 40.0 10 PDB header:immune system/oxidoreductase Chain: B: PDB Molecule:nitric oxide reductase subunit b; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment 9 d1xmea1 31.0 19 Fold:Cytochrome c oxidase subunit I-like Superfamily:Cytochrome c oxidase subunit I-like Family:Cytochrome c oxidase subunit I-like 10 c3kp9A_ 29.1 16 PDB header:blood coagulation,oxidoreductase Chain: A: PDB Molecule:vkorc1/thioredoxin domain protein; PDBTitle: structure of a bacterial homolog of vitamin k epoxide reductase 11 c2bbjB_ 17.1 17 PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter 12 c3lw52_ 16.2 21 PDB header:photosynthesis Chain: 2: PDB Molecule:type ii chlorophyll a/b binding protein from photosystem i; PDB Fragment:residues 81-246; PDBTitle: improved model of plant photosystem i 13 d2p3ha1 14.1 7 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 14 d2r2za1 13.5 36 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 15 d3deda1 11.5 36 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 16 d2o3ga1 11.0 29 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 17 c3fh6F_ 10.3 8 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 18 c3dedB_ 9.5 36 PDB header:membrane protein Chain: B: PDB Molecule:probable hemolysin; PDBTitle: c-terminal domain of probable hemolysin from chromobacterium violaceum 19 c1hgvA_ 9.1 23 PDB header:virus Chain: A: PDB Molecule:ph75 inovirus major coat protein; PDBTitle: filamentous bacteriophage ph75 20 d2a65a1 8.2 15 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 21 d2gz4a1 not modelled 8.2 12 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 22 d2oaia1 not modelled 7.9 43 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 23 c3lemA_ not modelled 7.9 19 PDB header:hydrolase Chain: A: PDB Molecule:fructosyltransferase; PDBTitle: crystal structure of fructosyltransferase (d191a) from a. japonicus in2 complex with nystose 24 d2nqwa1 not modelled 7.5 21 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 25 c2l9uA_ not modelled 7.3 20 PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-3; PDBTitle: spatial structure of dimeric erbb3 transmembrane domain 26 d2plsa1 not modelled 6.9 29 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 27 c3mepC_ not modelled 6.5 20 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein eca2234; PDBTitle: crystal structure of eca2234 protein from erwinia2 carotovora, northeast structural genomics consortium target3 ewr44 28 d2rk5a1 not modelled 6.5 36 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 29 c3kopB_ not modelled 6.4 22 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein with a cyclophilin-like fold2 (yp_831253.1) from arthrobacter sp. fb24 at 1.90 a resolution 30 c3k11A_ not modelled 6.0 13 PDB header:hydrolase Chain: A: PDB Molecule:putative glycosyl hydrolase; PDBTitle: crystal structure of putative glycosyl hydrolase (np_813087.1) from2 bacteroides thetaiotaomicron vpi-5482 at 1.80 a resolution 31 c3eh4A_ not modelled 5.9 13 PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c oxidase subunit 1; PDBTitle: structure of the reduced form of cytochrome ba3 oxidase from thermus2 thermophilus 32 c3llbA_ not modelled 5.8 36 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of the protein pa3983 with unknown2 function from pseudomonas aeruginosa pao1 33 d2axta1 not modelled 5.5 18 Fold:Bacterial photosystem II reaction centre, L and M subunits Superfamily:Bacterial photosystem II reaction centre, L and M subunits Family:Bacterial photosystem II reaction centre, L and M subunits 34 d2o1ra1 not modelled 5.1 14 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0