Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	T	F	H	T	N	H	G	D	I	V	I	K	T	F	D	D	K	A	P	E	T	V	K	N	F	L	D	Y	C	R	E	G	F	Y	N	N	T	I	F	H	R	V	I	N	G	F	M	I	Q	G	G	G	F	E	P	G	M	K
Secondary structure
SS confidence
Disorder		?					?																																																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	K	A	T	K	E	P	I	K	N	E	A	N	N	G	L	K	N	T	R	G	T	L	A	M	A	R	T	Q	A	P	H	S	A	T	A	Q	F	F	I	N	V	V	D	N	D	F	L	N	F	S	G	E	S	L	Q	G	W	G	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?																									?	?	?	?																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.
Sequence		C	V	F	A	E	V	V	D	G	M	D	V	V	D	K	I	K	G	V	A	T	G	R	S	G	M	H	Q	D	V	P	K	E	D	V	I	I	E	S	V	T	V	S	E
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?	?	?	?	?													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1lop chain A Region: 1 - 164 Aligned: 164 Modelled: 164 Confidence: 100.0% Identity: 99% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 3s6m chain A Region: 1 - 163 Aligned: 160 Modelled: 163 Confidence: 100.0% Identity: 66% PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: the structure of a peptidyl-prolyl cis-trans isomerase from2 burkholderia pseudomallei Phyre2 PDB 1v9t chain A Region: 2 - 163 Aligned: 159 Modelled: 162 Confidence: 100.0% Identity: 57% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2k7n chain A Region: 2 - 164 Aligned: 151 Modelled: 159 Confidence: 100.0% Identity: 31% PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase-like 1; PDBTitle: solution structure of the ppil1 bound to a fragment of skip Phyre2 PDB 2fu0 chain A domain 1 Region: 2 - 162 Aligned: 149 Modelled: 161 Confidence: 100.0% Identity: 32% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2a2n chain A domain 1 Region: 1 - 163 Aligned: 152 Modelled: 163 Confidence: 100.0% Identity: 35% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 3bo7 chain D Region: 2 - 164 Aligned: 151 Modelled: 163 Confidence: 100.0% Identity: 30% PDB header:isomerase/immunosuppressant Chain: D: PDB Molecule:peptidyl-prolyl cis-trans isomerase cyclophilin-type; PDBTitle: crystal structure of toxoplasma gondii peptidyl-prolyl cis-trans2 isomerase, 541.m00136 Phyre2 PDB 2b71 chain A domain 1 Region: 2 - 161 Aligned: 148 Modelled: 160 Confidence: 100.0% Identity: 33% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2b71 chain A Region: 2 - 161 Aligned: 148 Modelled: 160 Confidence: 100.0% Identity: 33% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein; PDBTitle: plasmodium yoelii cyclophilin-like protein Phyre2 PDB 2ok3 chain A domain 1 Region: 2 - 164 Aligned: 152 Modelled: 155 Confidence: 100.0% Identity: 32% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1ihg chain A Region: 2 - 164 Aligned: 150 Modelled: 163 Confidence: 100.0% Identity: 29% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin 40; PDBTitle: bovine cyclophilin 40, monoclinic form Phyre2 PDB 1zkc chain A domain 1 Region: 2 - 163 Aligned: 151 Modelled: 162 Confidence: 100.0% Identity: 34% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2hq6 chain A Region: 2 - 164 Aligned: 151 Modelled: 163 Confidence: 100.0% Identity: 30% PDB header:isomerase Chain: A: PDB Molecule:serologically defined colon cancer antigen 10; PDBTitle: structure of the cyclophilin_cecyp16-like domain of the serologically2 defined colon cancer antigen 10 from homo sapiens Phyre2 PDB 1xwn chain A domain 1 Region: 2 - 163 Aligned: 150 Modelled: 154 Confidence: 100.0% Identity: 31% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1w74 chain A Region: 2 - 163 Aligned: 149 Modelled: 162 Confidence: 100.0% Identity: 38% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2qer chain A Region: 2 - 164 Aligned: 151 Modelled: 162 Confidence: 100.0% Identity: 32% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein, putative; PDBTitle: crystal structure of cryptosporidium parvum cyclophilin type peptidyl-2 prolyl cis-trans isomerase cgd2_1660 in the presence of dipeptide3 ala-pro Phyre2 PDB 1ihg chain A domain 2 Region: 2 - 164 Aligned: 150 Modelled: 163 Confidence: 100.0% Identity: 28% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2he9 chain B Region: 1 - 163 Aligned: 151 Modelled: 163 Confidence: 100.0% Identity: 30% PDB header:isomerase Chain: B: PDB Molecule:nk-tumor recognition protein; PDBTitle: structure of the peptidylprolyl isomerase domain of the2 human nk-tumour recognition protein Phyre2 PDB 1xo7 chain A Region: 2 - 163 Aligned: 149 Modelled: 158 Confidence: 100.0% Identity: 38% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1cyn chain A Region: 1 - 164 Aligned: 152 Modelled: 164 Confidence: 100.0% Identity: 32% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 1 d1lopa_ 2 c3s6mA_ 3 d1v9ta_ 4 c2k7nA_ 5 d2fu0a1 6 d2a2na1 7 c3bo7D_ 8 d2b71a1 9 c2b71A_ 10 d2ok3a1 11 c1ihgA_ 12 d1zkca1 13 c2hq6A_ 14 d1xwna1 15 d1w74a_ 16 c2qerA_ 17 d1ihga2 18 c2he9B_ 19 d1xo7a_ 20 d1cyna_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1lopa_ 100.0 99 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 2 c3s6mA_ 100.0 66 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: the structure of a peptidyl-prolyl cis-trans isomerase from2 burkholderia pseudomallei 3 d1v9ta_ 100.0 57 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 4 c2k7nA_ 100.0 31 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase-like 1; PDBTitle: solution structure of the ppil1 bound to a fragment of skip 5 d2fu0a1 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 6 d2a2na1 100.0 35 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 7 c3bo7D_ 100.0 30 PDB header:isomerase/immunosuppressant Chain: D: PDB Molecule:peptidyl-prolyl cis-trans isomerase cyclophilin-type; PDBTitle: crystal structure of toxoplasma gondii peptidyl-prolyl cis-trans2 isomerase, 541.m00136 8 d2b71a1 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 9 c2b71A_ 100.0 33 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein; PDBTitle: plasmodium yoelii cyclophilin-like protein 10 d2ok3a1 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 11 c1ihgA_ 100.0 29 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin 40; PDBTitle: bovine cyclophilin 40, monoclinic form 12 d1zkca1 100.0 34 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 13 c2hq6A_ 100.0 30 PDB header:isomerase Chain: A: PDB Molecule:serologically defined colon cancer antigen 10; PDBTitle: structure of the cyclophilin_cecyp16-like domain of the serologically2 defined colon cancer antigen 10 from homo sapiens 14 d1xwna1 100.0 31 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 15 d1w74a_ 100.0 38 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 16 c2qerA_ 100.0 32 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein, putative; PDBTitle: crystal structure of cryptosporidium parvum cyclophilin type peptidyl-2 prolyl cis-trans isomerase cgd2_1660 in the presence of dipeptide3 ala-pro 17 d1ihga2 100.0 28 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 18 c2he9B_ 100.0 30 PDB header:isomerase Chain: B: PDB Molecule:nk-tumor recognition protein; PDBTitle: structure of the peptidylprolyl isomerase domain of the2 human nk-tumour recognition protein 19 d1xo7a_ 100.0 38 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 20 d1cyna_ 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 21 c3k2cA_ not modelled 100.0 32 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: crystal structure of peptidyl-prolyl cis-trans isomerase2 from encephalitozoon cuniculi at 1.9 a resolution 22 d2esla1 not modelled 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 23 c3bkpA_ not modelled 100.0 33 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin; PDBTitle: crystal structure of the toxoplasma gondii cyclophilin, 49.m03261 24 c2poyB_ not modelled 100.0 30 PDB header:isomerase/immunosuppressant Chain: B: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans2 isomerase cgd2_4120 in complex with cyclosporin a 25 c1z81A_ not modelled 100.0 29 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin; PDBTitle: crystal structure of cyclophilin from plasmodium yoelii. 26 d1z81a1 not modelled 100.0 29 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 27 d2rmca_ not modelled 100.0 34 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 28 c2ck1A_ not modelled 100.0 35 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase e; PDBTitle: the structure of oxidised cyclophilin a from s. mansoni 29 d1qnga_ not modelled 100.0 29 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 30 d1vdna1 not modelled 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 31 d1w8ma_ not modelled 100.0 26 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 32 d1a33a_ not modelled 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 33 d1h0pa_ not modelled 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 34 d2z6wa1 not modelled 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 35 d2igva1 not modelled 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 36 d2r99a1 not modelled 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 37 d1qoia_ not modelled 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 38 c2oseA_ not modelled 100.0 22 PDB header:isomerase Chain: A: PDB Molecule:probable peptidyl-prolyl cis-trans isomerase; PDBTitle: crystal structure of the mimivirus cyclophilin 39 d2cfea1 not modelled 100.0 36 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 40 d2c3ba1 not modelled 100.0 34 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 41 c2nnzA_ not modelled 96.1 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: solution structure of the hypothetical protein af2241 from2 archaeoglobus fulgidus 42 c3kopB_ not modelled 95.9 18 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein with a cyclophilin-like fold2 (yp_831253.1) from arthrobacter sp. fb24 at 1.90 a resolution 43 d1zx8a1 not modelled 93.5 16 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:TM1367-like 44 c2khfA_ not modelled 15.9 50 PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in dpc-micelles 45 c2khgA_ not modelled 13.8 50 PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in tfe 46 c3ipfA_ not modelled 12.3 31 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the q251q8_deshy protein from desulfitobacterium2 hafniense. northeast structural genomics consortium target dhr8c.

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0