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Job DescriptionP63389
Confidence100.00%DateThu Jan 5 12:08:08 GMT 2012
Rank5Aligned Residues476
% Identity25%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   2.......10. ........20.........30.........40.........50.........60..... ..
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Query Sequence  IVFSSLQIRR. . . GVRVLLDNATATINPGQKVGLVGKNGCGKSTLLALLKNEISADGGSYTFPGSWQ. . . . . . . . . . . LA
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIG
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460.......
 
   68.70.........80.........90.........100.........110.........120.........130.........140.......
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Query Sequence  WVNQETPALPQAALEYVIDGDREYRQLEAQLHDANERNDGHAIATIHGKLDAIDAWSIRSRAASLLHGLGFSNEQLERPV
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Template Conservation     
   
   
   

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Template Sequence  VVSQEPVLFATTIAENIRYGREDVTM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DEIEKAVKEANAYDFIMKLPH
Template Known Secondary structure  SS



SS

SS

.................................TT
TTSTT
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   468.470.........480.........490... ......500.........510....
 
   148 .150.........160.........170.........180.........190..... ....200.........210.....
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Query Sequence  S. . . . . . . . . . DFSGGWRMRLNLAQALICRSDLLLLDEPTNHLDLDAVIWLEKWLKSY. . QGTLILISHDRDFLDPIVDK
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Template Sequence  QFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVR. NADV
Template Known Secondary structure  GGG


SSSS
SS


SBTT
SS
TTSS
S
T.T
S
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   515....520.........530.........540.........550.........560.........570.........580......... 590...
 
   216...220.........230.........240.........250.........260.........
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Query Sequence  IIHIEQQSMFEYTGNYSSFEVQRATRLAQQQAMYESQQERVAHLQSYIDRFRAK. . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  IAGFDGGVIVE. QGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS
Template Known Secondary structure 
SSS



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TST









TTT



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   594.....600.... .....610.........620.........630.........640.........650.........660.........670..
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                    
                   
   
   
               
 
Template Sequence  KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA
Template Known Secondary structure  SS
STT

S
S

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   730.........740.........750.........760.........770.........780.........790.........800.........
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
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Template Sequence  LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS
Template Known Secondary structure  SS
STT
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   810.........820.........830.........840.........850.........860.........870.........880.........
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFEN
Template Known Secondary structure  TT
TTTTT
SS

TTTT
S
STT
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   890.........900.........910.........920.........930.........940.........950.........960.........
 
   270.........280.........290.........300.........310.........320.. ......
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Query Sequence  . . . . . . . . . . . . . . . . . . ATKAKQAQSRIKMLERMELIAPAHVDNPFRFSFRAPESLPNPLLKMEKVSAGY. . . GDRIIL
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Template Conservation                   
            
  

   
                    
 
    
   
       

Template Sequence  VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL
Template Known Secondary structure  TSSSS
SS




SS
S




TTT





S
GGG

S
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   970.........980.........990.........1000.........1010.........1020.........1030.........1040.........
 
   329330.........340.........350.........360.........370. .... ....380.........390.......
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Query Sequence  DSIKLNLVPGSRIGLLGRNGAGKSTLIKLLAGELAPVSGEIGL. AKGI. . . . . . . . . . KLGYFAQHQLEYLRADESPIQH
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Template Sequence  QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQ. . . EPILFDCSIAEN
Template Known Secondary structure  S


SSS
SSSTTTTSS

SSSSS
BTSS
TTS
S...S



SSB
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   1050.........1060.........1070.........1080.........1090.........1100.........1110.... .....1120......
 
   398.400.... .....410.........420 ......... 430.........440.........450.........460.....
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Query Sequence  LARLAPQ. . ELEQKLRDYLGGFGFQ. . . . . . GDKVTEETR. . . . RFSGGEKARLVLALIVWQRPNLLLLDEPTNHLDLDM
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Template Sequence  IAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTES
Template Known Secondary structure  T


SS



T
SSTTTGGG
B
STTS
SS


SSS
SSS

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   1127..1130.........1140.........1150.........1160.........1170.........1180.........1190.........1200......
 
   466...470...... ...480.........490.........500.........510.......
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Query Sequence  RQALTEALIEF. . EGALVVVSHDRHLLRSTTDDLYLVHDRKVEPFDGDLEDYQQ
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Template Sequence  EKVVQEALDKAREGRTCIVIAHRLSTIQ. NADLIVVIQNGKVKE. HGTHQQLLA
Template Known Secondary structure  SSSS

S
TTGGG.S
STB.
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   1207..1210.........1220.........1230.... .....1240......... 1250........
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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