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Job DescriptionP75796
Confidence100.00%DateThu Jan 5 12:14:14 GMT 2012
Rank2Aligned Residues500
% Identity27%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   2.......10.........20.........30.........40.........50.........60.........70.........80.
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Query Sequence  PHSDELDAGNVLAVENLNIAFMQDQQKIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLLEQAGGLVQCDKMLLQ
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Template Sequence  SGHKPDNIQGNLEFKNIHFSYPSRKEVQ. ILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQ. . .
Template Known Secondary structure 




TT
S



SSTTS

.S
TT


SSTTTTTSS

STT...
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   377..380.........390.........400.... .....410.........420.........430.........440.........450..
 
   82.......90.........100.........110.........120.........130.........140.........150........
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Query Sequence  RRSREVIELSEQNAAQMRHVRGADMAMIFQEPMTSLNPVFTVGEQIAESIRLHQNASREEAMVEAKRMLDQVRIPEA. . .
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Template Sequence  . . . . . . . DIRTINVRYLR. . . . EIIGVVSQEP. . . VLFATTIAENIRYG. . . . . . . REDVTMDEIEKAVKEANAYDFIMK
Template Known Secondary structure  .......GGGS
....SS
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SS
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SS

TT
TT
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   453......460... ......470... ......480....... ..490.........500.........510.
 
   159160.........170.........180.........190.........200.........210.........220.........230...
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Query Sequence  . . . . . QTILSRYPHQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQKEMSMGVIFITHDMGVVA
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Template Sequence  LPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE. . GRTTIVIAHRLSTVR
Template Known Secondary structure  STTGGG


SSSS
SS


SBTT
SS
TT..SS
S
T
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   512.......520.........530.........540.........550.........560.........570.... .....580.........
 
   234.....240.........250.........260....
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Query Sequence  EIADRVLVMYQGEAVETGTVEQIFHAPQHPY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation  .  
 
     
     
    
                                               
         
Template Sequence  . NADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFS
Template Known Secondary structure  .T
S
SSS




TST









TTT



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   590.........600.........610.........620.........630.........640.........650.........660........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                        
                   
   
   
             
Template Sequence  VIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKN
Template Known Secondary structure  SS
STT

S
S
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   726...730.........740.........750.........760.........770.........780.........790.........800.....
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation    
 
  
   
           
   
          
        
 

 
    
                      
Template Sequence  TTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE
Template Known Secondary structure 
SS
STT
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   806...810.........820.........830.........840.........850.........860.........870.........880.....
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
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Template Sequence  LEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLM
Template Known Secondary structure  TT
TTTTT
SS

TTTT
S
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   886...890.........900.........910.........920.........930.........940.........950.........960.....
 
   265....270.........280.........290.........300.........310......
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . TRALLAAVPQLGAMKGLDYPRRFPLISLEHPAKQAPPIEQKTVVDGEPVLRV
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Template Sequence  TFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGN. . . . . . . . . . . . VQF
Template Known Secondary structure 
STTTSSSS
SS




SS
S




TTT



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   966...970.........980.........990.........1000.........1010.........1020.........1030 ...
 
   317..320.........330.........340.........350.........360.........370.........380.........390......
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Query Sequence  RNLVTRFPLRSGLLNRVTREVHAVEKVSFDLWPGETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNGQRIDTLSPGKL
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Template Sequence  SGVVFNYPTR. . . . . . . . PSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQW.
Template Known Secondary structure 

S
G........GG

SS


SSS
SSSTTTTSS

SSSSS
BTSS
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   1034.....1040... ......1050.........1060.........1070.........1080.........1090.........1100....
 
   397..400.........410.........420.........430.........440.........450.........460.. ...
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Query Sequence  QALRRDIQFIFQDPYASLDPRQTIGDSIIEPLRVHGLLPGKDAAARVAWLLERVGLLPEHAWRYPH. . . . . . . . . . . EFS
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Template Sequence  . . LRAQLGIVSQEPI. . LFDC. SIAENIA. . . . . YGDNSRVVSYEEIVRAAKEANI. HQFIDSLPDKYNTRVGDKGTQLS
Template Known Secondary structure  ..TTS
SS

..

SS.BT.....


SS



T
.SSTTTGGG
B
STTS
SS
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   1105....1110....... ..1120. ....... .1130.........1140.........1150 .........1160.........1170...
 
   466...470.........480.........490.........500.........510.........520.........530.........540.....
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Query Sequence  GGQRQRICIARALALNPKVIIADEAVSALDVSIRGQIINLLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVEI
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Template Sequence  GGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKARE. . GRTCIVIAHRLSTIQN. ADLIVVIQNGKVKEH
Template Known Secondary structure 

SSS
SSS

SS..SS

S
TTGGGS.
STB
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   1174.....1180.........1190.........1200.........1210......... 1220.........1230..... ....1240.........1250
 
   546...550.........560......
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Query Sequence  GPRRAVFENPQHPYTRKLLAA
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Template Conservation 
    
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Template Sequence  GTHQQLLAQ. KGIY. FSMVSV
Template Known Secondary structure 
S.
S.
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   1251........ 1260... ......
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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