Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	L	T	A	Q	Q	I	A	C	V	Y	A	W	L	A	Q	L	F	S	R	E	L	D	D	E	Q	L	T	Q	I	A	S	A	Q	M	A	E	W	F	S	L	L	K	S	E	P	P	L	T	A	A	V	N	E	L	E	N	R
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	A	T	L	T	V	R	D	D	A	R	L	E	L	A	A	D	F	C	G	L	F	L	M	T	D	K	Q	A	A	L	P	Y	A	S	A	Y	K	Q	D	E	Q	E	I	K	R	L	L	V	E	A	G	M	E	T	S	G	N	F	N
Secondary structure
SS confidence
Disorder																																																									?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	P	A	D	H	L	A	I	Y	L	E	L	L	S	H	L	H	F	S	L	G	E	G	T	V	P	A	R	R	I	D	S	L	R	Q	K	T	L	T	A	L	W	Q	W	L	P	E	F	V	A	R	C	R	Q	Y	D	S	F	G	F
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.
Sequence		Y	A	A	L	S	Q	L	L	L	V	L	V	E	C	D	H	Q	N	R
Secondary structure
SS confidence
Disorder																			?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1n1c chain A Region: 6 - 197 Aligned: 181 Modelled: 192 Confidence: 100.0% Identity: 33% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 1s9u chain A Region: 4 - 197 Aligned: 173 Modelled: 194 Confidence: 100.0% Identity: 20% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2o9x chain A Region: 7 - 193 Aligned: 147 Modelled: 162 Confidence: 100.0% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus Phyre2 PDB 2o9x chain A domain 1 Region: 11 - 193 Aligned: 143 Modelled: 165 Confidence: 99.9% Identity: 20% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2idg chain A domain 1 Region: 104 - 188 Aligned: 82 Modelled: 84 Confidence: 99.7% Identity: 15% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2vof chain A Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 66.1% Identity: 7% PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain Phyre2 PDB 2iic chain A Region: 1 - 82 Aligned: 81 Modelled: 82 Confidence: 37.0% Identity: 16% PDB header:metal binding protein Chain: A: PDB Molecule:alpha-11 giardin; PDBTitle: calcium bound structure of alpha-11 giardin Phyre2 PDB 1ysg chain A domain 1 Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 37.0% Identity: 14% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 3qbr chain A Region: 125 - 165 Aligned: 41 Modelled: 41 Confidence: 33.5% Identity: 17% PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja Phyre2 PDB 1g5m chain A Region: 126 - 167 Aligned: 42 Modelled: 42 Confidence: 24.1% Identity: 10% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2pon chain B domain 1 Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 23.6% Identity: 14% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1o0l chain A Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 22.7% Identity: 12% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2jm6 chain B domain 1 Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 22.4% Identity: 7% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1pq1 chain A Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 21.4% Identity: 12% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1m3v chain A domain 2 Region: 75 - 86 Aligned: 12 Modelled: 12 Confidence: 21.1% Identity: 25% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 2r7m chain A Region: 76 - 124 Aligned: 49 Modelled: 49 Confidence: 20.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:5-formaminoimidazole-4-carboxamide-1-(beta)-d- PDBTitle: crystal structure of faicar synthetase (purp) from m.2 jannaschii complexed with amp Phyre2 PDB 3pk1 chain A Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 20.0% Identity: 9% PDB header:apoptosis/apoptosis regulator Chain: A: PDB Molecule:induced myeloid leukemia cell differentiation protein mcl- PDBTitle: crystal structure of mcl-1 in complex with the baxbh3 domain Phyre2 PDB 1zy3 chain A domain 1 Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 18.8% Identity: 12% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1bxl chain A Region: 125 - 165 Aligned: 41 Modelled: 41 Confidence: 18.7% Identity: 10% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2o2f chain A Region: 125 - 167 Aligned: 43 Modelled: 43 Confidence: 16.9% Identity: 7% PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand Phyre2 1 d1n1ca_ 2 d1s9ua_ 3 c2o9xA_ 4 d2o9xa1 5 d2idga1 6 c2vofA_ 7 c2iicA_ 8 d1ysga1 9 c3qbrA_ 10 d1g5ma_ 11 d2ponb1 12 d1o0la_ 13 d2jm6b1 14 d1pq1a_ 15 d1m3va2 16 c2r7mA_ 17 c3pk1A_ 18 d1zy3a1 19 d1bxla_ 20 c2o2fA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1n1ca_ 100.0 33 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 2 d1s9ua_ 100.0 20 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 3 c2o9xA_ 100.0 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus 4 d2o9xa1 99.9 20 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 5 d2idga1 99.7 15 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 6 c2vofA_ 66.1 7 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain 7 c2iicA_ 37.0 16 PDB header:metal binding protein Chain: A: PDB Molecule:alpha-11 giardin; PDBTitle: calcium bound structure of alpha-11 giardin 8 d1ysga1 37.0 14 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 9 c3qbrA_ 33.5 17 PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja 10 d1g5ma_ 24.1 10 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 11 d2ponb1 23.6 14 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 12 d1o0la_ 22.7 12 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 13 d2jm6b1 22.4 7 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 14 d1pq1a_ 21.4 12 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 15 d1m3va2 21.1 25 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 16 c2r7mA_ 20.0 20 PDB header:ligase Chain: A: PDB Molecule:5-formaminoimidazole-4-carboxamide-1-(beta)-d- PDBTitle: crystal structure of faicar synthetase (purp) from m.2 jannaschii complexed with amp 17 c3pk1A_ 20.0 9 PDB header:apoptosis/apoptosis regulator Chain: A: PDB Molecule:induced myeloid leukemia cell differentiation protein mcl- PDBTitle: crystal structure of mcl-1 in complex with the baxbh3 domain 18 d1zy3a1 18.8 12 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 19 d1bxla_ 18.7 10 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 20 c2o2fA_ 16.9 7 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand 21 c2xa0A_ not modelled 16.3 7 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: crystal structure of bcl-2 in complex with a bax bh32 peptide 22 c2yv6A_ not modelled 13.9 7 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2 homologous antagonist/killer; PDBTitle: crystal structure of human bcl-2 family protein bak 23 c3chlA_ not modelled 12.4 12 PDB header:metal binding protein Chain: A: PDB Molecule:alpha-14 giardin; PDBTitle: crystal structure of alpha-14 giardin with magnesium bound 24 d1f16a_ not modelled 12.3 12 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 25 d1rutx2 not modelled 11.4 38 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 26 d1hm6a_ not modelled 11.0 19 Fold:Annexin Superfamily:Annexin Family:Annexin 27 c2a5yA_ not modelled 11.0 10 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator ced-9; PDBTitle: structure of a ced-4/ced-9 complex 28 d1ohua_ not modelled 10.4 9 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 29 d1m9ia2 not modelled 9.4 15 Fold:Annexin Superfamily:Annexin Family:Annexin 30 c1q8hA_ not modelled 9.0 19 PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin 31 d1q8ha_ not modelled 9.0 19 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 32 c2ehhE_ not modelled 8.6 16 PDB header:lyase Chain: E: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 aquifex aeolicus 33 c2qecA_ not modelled 8.4 19 PDB header:transferase Chain: A: PDB Molecule:histone acetyltransferase hpa2 and related PDBTitle: crystal structure of histone acetyltransferase hpa2 and related2 acetyltransferase (np_600742.1) from corynebacterium glutamicum atcc3 13032 at 1.90 a resolution 34 d1qfma2 not modelled 6.3 16 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Prolyl oligopeptidase, C-terminal domain 35 d1q3ma_ not modelled 6.3 22 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 36 d1w7ba_ not modelled 6.2 16 Fold:Annexin Superfamily:Annexin Family:Annexin 37 c2k5tA_ not modelled 6.1 15 PDB header:transferase Chain: A: PDB Molecule:uncharacterized protein yhhk; PDBTitle: solution nmr structure of putative n-acetyl transferase2 yhhk from e. coli bound to coenzyme a: northeast3 structural genomics consortium target et106 38 d1i4aa_ not modelled 6.1 11 Fold:Annexin Superfamily:Annexin Family:Annexin 39 d1k3ka_ not modelled 5.9 17 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 40 d1ycna_ not modelled 5.8 15 Fold:Annexin Superfamily:Annexin Family:Annexin 41 c2kngA_ not modelled 5.6 22 PDB header:dna binding protein Chain: A: PDB Molecule:protein lsr2; PDBTitle: solution structure of c-domain of lsr2 42 c3k6gA_ not modelled 5.4 28 PDB header:protein binding Chain: A: PDB Molecule:telomeric repeat-binding factor 2-interacting protein 1; PDBTitle: crystal structure of rap1 and trf2 complex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0