Job Description P14294 Confidence 100.00% Date Thu Jan 5 11:33:58 GMT 2012 Rank 4 Aligned Residues 562 % Identity 21% Template c2gajA_ PDB info PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase i; PDBTitle: structure of full length topoisomerase i from thermotoga maritima in2 monoclinic crystal form Resolution 1.95 Å

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		2	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	L	F	I	A	E	K	P	S	L	A	R	A	I	A	D	V	L	P	K	P	H	R	K	G	D	G	F	I	E	C	G	N	G	Q	V	V	T	W	C	I	G	H	L	L	E	Q	A	Q	P	D	A	Y	D	S	R	Y	A	R	W	N	L	A	D	L	P	I	V	P	E	K	W	Q	L	Q	P	R	P	S	V
Query Conservation
Alig confidence																				.	.	.	.	.	.	.	.	.	.	.	.	.																														.	.	.	.	.	.	.	.	.	.
Template Conservation																				.	.	.	.	.	.	.	.	.	.	.	.	.																														.	.	.	.	.	.	.	.	.	.
Template Sequence		K	Y	I	V	V	E	S	P	A	K	A	K	T	I	K	S	I	L	.	.	.	.	.	.	.	.	.	.	.	.	.	G	N	E	Y	E	V	F	A	S	M	G	H	I	I	D	L	P	K	S	K	F	G	V	D	L	E	K	D	F	.	.	.	.	.	.	.	.	.	.	E	P	E	F	A	V	I	K	G	K
Template Known Secondary structure							S													.	.	.	.	.	.	.	.	.	.	.	.	.	G	G	G	S							S		S			S		S	S	S					T	T	T	T	T	.	.	.	.	.	.	.	.	.	.								T	T
Template Predicted Secondary structure																				.	.	.	.	.	.	.	.	.	.	.	.	.																														.	.	.	.	.	.	.	.	.	.
Template SS confidence
		7	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.														.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.											.	.	.	.	.	.	60	.	.	.
		82	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	K	Q	L	N	V	I	K	R	F	L	H	E	A	S	E	I	V	H	A	G	D	P	D	R	E	G	Q	L	L	V	D	E	V	L	D	Y	L	Q	L	A	P	E	K	R	Q	Q	V	Q	R	C	L	I	N	D	L	N	P	Q	A	V	E	R	A	I	D	R	L	R	S	N	S	E	F	V	P	L	C	V	S
Query Conservation
Alig confidence																	.																									.	.	.	.																													.	.
Template Conservation																	.																									.	.	.	.																													.	.
Template Sequence		E	K	V	V	E	K	L	K	D	L	A	K	K	G	E	.	L	L	I	A	S	D	M	D	R	E	G	E	A	I	A	W	H	I	A	R	V	T	N	T	.	.	.	.	L	G	R	K	N	R	I	V	F	S	E	I	T	P	R	V	I	R	E	A	V	K	N	P	R	E	I	D	.	.	M	K	K	V	R	A
Template Known Secondary structure															S		.							S	S															T		.	.	.	.	T	T	S	S		B				S											T	T	S		B				.	.
Template Predicted Secondary structure																	.																									.	.	.	.																													.	.
Template SS confidence
		64	.	.	.	.	.	70	.	.	.	.	.	.	.	.		.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.					.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130			.	.	.	.	.	.
		162	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	L	A	R	A	R	A	D	W	L	Y	G	I	N	M	T	R	A	Y	T	I	L	G	R	N	A	G	Y	Q	G	V	L	S	V	G	R	V	Q	T	P	V	L	G	L	V	V	R	R	D	E	E	I	E	N	F	V	A	K	D	F	F	E	V	K	A	H	I	V	T	P	A	D	E	R	F	T	A	I	W	Q
Query Conservation
Alig confidence																								.	.	.	.	.																																													.	.	.	.	.	.	.	.	.
Template Conservation																								.	.	.	.	.																																													.	.	.	.	.	.	.	.	.
Template Sequence		Q	L	A	R	R	I	L	D	R	I	V	G	Y	S	L	S	P	V	L	W	R	N	.	.	.	.	.	F	K	S	N	L	S	A	G	R	V	Q	S	A	T	L	K	L	V	C	D	R	E	R	E	I	L	R	F	V	P	K	K	Y	H	R	I	T	V	N	F	D	G	L	T	.	.	.	.	.	.	.	.	.
Template Known Secondary structure																								.	.	.	.	.		S				T	T																				T														T	T			.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																								.	.	.	.	.																																													.	.	.	.	.	.	.	.	.
Template SS confidence
		137	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.						.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.
		242	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	S	E	A	C	E	P	Y	Q	D	E	E	G	R	L	L	H	R	P	L	A	E	H	V	V	N	R	I	S	G	Q	P	A	I	V	T	S	Y	N	D	K	R	E	S	E	S	A	P	L	P	F	S	L	S	A	L	Q	I	E	A	A	K	R	F	G	L	S	A	Q	N	V	L	D	I	C	Q	K	L	Y	E
Query Conservation
Alig confidence		.	.	.	.	.																						.	.	.
Template Conservation		.	.	.	.	.																						.	.	.
Template Sequence		.	.	.	.	.	A	E	I	D	V	K	E	K	K	F	F	D	A	E	T	L	K	E	I	Q	S	.	.	.	I	D	E	L	V	V	E	E	K	K	V	S	V	K	K	F	A	P	P	E	P	F	K	T	S	T	L	Q	Q	E	A	Y	S	K	L	G	F	S	V	S	K	T	M	M	I	A	Q	Q	L	Y	E
Template Known Secondary structure		.	.	.	.	.						S	S														T	.	.	.																						B
Template Predicted Secondary structure		.	.	.	.	.																						.	.	.
Template SS confidence
							203	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.				.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.
		322	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.						.	.
Predicted Secondary structure																																																																											.	.	.	.	.
Query SS confidence																																																																											.	.	.	.	.
Query Sequence		T	H	K	L	I	T	Y	P	R	S	D	C	R	Y	L	P	E	E	H	F	A	G	R	H	A	V	M	N	A	I	S	V	H	A	P	D	L	L	P	Q	P	V	V	D	P	D	I	R	N	R	C	W	D	D	K	K	V	D	A	H	H	A	I	I	P	T	A	R	S	S	A	I	N	.	.	.	.	.	L	T
Query Conservation																																																																											.	.	.	.	.
Alig confidence		.																																			.	.	.	.	.	.	.	.	.	.	.	.	.																										.	.	.	.	.
Template Conservation		.																																			.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	G	V	E	T	K	D	G	H	I	A	F	I	T	Y	M	R	T	D	S	T	R	V	S	D	Y	A	K	E	E	A	R	N	L	I	.	.	.	.	.	.	.	.	.	.	.	.	.	T	E	V	F	G	E	E	Y	V	G	A	H	E	A	I	R	P	T	N	V	F	M	T	P	E	E	A	G	K	Y	L	N
Template Known Secondary structure		.					S	S						B			S			S																	.	.	.	.	.	.	.	.	.	.	.	.	.				T		G	G	G	B						B		B	S		T	T	S						T	T	T	S
Template Predicted Secondary structure		.																																			.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
			275	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.														.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340
		397	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.			440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.
Predicted Secondary structure																																													.	.
Query SS confidence																																													.	.
Query Sequence		E	N	E	A	K	V	Y	N	L	I	A	R	Q	Y	L	M	Q	F	C	P	D	A	V	F	R	K	C	V	I	E	L	D	I	A	K	G	K	F	V	A	K	A	R	.	.	F	L	A	E	A	G	W	R	T	L	L	G	S	K	E	R	D	E	E	N	D	G	T	P	L	P	V	V	A	K	G	D	E	L	L
Query Conservation																																													.	.
Alig confidence																																													.	.																			.	.	.	.	.	.
Template Conservation																																																																	.	.	.	.	.	.
Template Sequence		S	D	Q	K	K	L	Y	E	L	I	W	K	R	F	L	A	S	Q	M	K	P	S	Q	Y	E	E	T	R	F	V	L	R	T	K	D	G	K	Y	R	F	K	G	T	V	L	K	K	I	F	D	G	Y	E	K	V	W	K	T	E	R	N	T	G	.	.	.	.	.	.	E	F	P	F	E	E	G	E	S	V	K
Template Known Secondary structure																			T	B															T	T	S	S														G	G	G	G	T	S						B		.	.	.	.	.	.						T	T
Template Predicted Secondary structure																																																																	.	.	.	.	.	.
Template SS confidence
		355	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.							.	.	420	.	.	.	.	.	.	.	.
		475	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		C	E	K	G	E	V	V	E	R	Q	T	Q	P	P	R	H	F	T	D	A	T	L	L	S	A	M	T	G	I	A	R	F	V	Q	D	K	D	L	K	K	I	L	R	A	T	D	G	L	G	T	E	A	T	R	A	G	I	I	E	L	L	F	K	R	G	F	L	T	K	K	G	R	Y	I	H	S	T	D	A	G
Query Conservation
Alig confidence																															.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																															.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		P	V	V	V	K	I	E	E	Q	E	T	K	P	K	P	R	Y	T	E	G	S	L	V	K	E	M	E	R	L	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	G	I	G	R	P	S	T	Y	A	S	T	I	K	L	L	L	N	R	G	Y	I	K	K	I	R	G	Y	L	Y	P	T	I	V	G
Template Known Secondary structure																															.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T		S		T	T	T											T	T	S					T	T					B
Template Predicted Secondary structure																															.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		429	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.																		.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.
		555	.	.	.	.	560	.	.	.	.				.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.
Predicted Secondary structure												.	.	.
Query SS confidence												.	.	.
Query Sequence		K	A	L	F	H	S	L	P	E	M	.	.	.	A	T	R	P	D	M	T	A	H	W	E	S	V	L	T	Q	I	S	E	K	Q	C	R	Y	Q	D	F	M	Q	P	L	V	G	T	L	Y	Q	L	I	D	Q	A	K	R	T	P	V	R	Q	F	R	G	I	V	A	P	G	S	G	G	S	A	D	K	K	K	A
Query Conservation												.	.	.
Alig confidence												.	.	.																																																									.
Template Conservation																																																																							.
Template Sequence		S	V	V	M	D	Y	L	E	K	K	Y	S	D	V	V	S	V	S	F	T	A	E	M	E	K	D	L	D	E	V	E	Q	G	K	K	T	D	K	I	V	L	R	E	F	Y	E	S	F	S	S	V	F	D	R	N	D	R	I	V	V	D	F	P	T	N	Q	K	C	S	.	C	G	K	E	M	R	L	S	F	G
Template Known Secondary structure												S	T	T	T	T	S																T	T	S	S																			T	T														S	.	S	S
Template Predicted Secondary structure																																																																							.
Template SS confidence
		492	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560		.	.	.	.	.	.	.	.	.	570
		632	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	P	R	K	R	S	A	K	K	S	P	P	A	D	E	V	G	S	G	A	I	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		K	Y	G	F	Y	L	K	C	E	C	G	K	T	R	S	V	K	N	D	E	I	A
Template Known Secondary structure		T	T							S	S	S							T	T	S	B
Template Predicted Secondary structure
Template SS confidence
		571	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.