Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	Q	K	A	T	L	I	G	L	I	A	I	V	L	W	S	T	M	V	G	L	I	R	G	V	S	E	G	L	G	P	V	G	G	A	A	A	I	Y	S	L	S	G	L	L	L	I	F	T	V	G	F	P	R	I	R	Q	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																																		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	K	G	Y	L	L	A	G	S	L	L	F	V	S	Y	E	I	C	L	A	L	S	L	G	Y	A	A	T	H	H	Q	A	I	E	V	G	M	V	N	Y	L	W	P	S	L	T	I	L	F	A	I	L	F	N	G	Q	K	T	N	W
Secondary structure
SS confidence
Disorder																													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	I	V	P	G	L	L	L	A	L	V	G	V	C	W	V	L	G	G	D	N	G	L	H	Y	D	E	I	I	N	N	I	T	T	S	P	L	S	Y	F	L	A	F	I	G	A	F	I	W	A	A	Y	C	T	V	T	N	K	Y	A
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	G	F	N	G	I	T	V	F	V	L	L	T	G	A	S	L	W	V	Y	Y	F	L	T	P	Q	P	E	M	I	F	S	T	P	V	M	I	K	L	I	S	A	A	F	T	L	G	F	A	Y	A	A	W	N	V	G	I	L	H	G
Secondary structure
SS confidence
Disorder		?	?	?																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.
Sequence		N	V	T	I	M	A	V	G	S	Y	F	T	P	V	L	S	S	A	L	A	A	V	L	L	S	A	P	L	S	F	S	F	W	Q	G	A	L	M	V	C	G	G	S	L	L	C	W	L	A	T	R	R	G
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1s7b chain A Region: 220 - 291 Aligned: 72 Modelled: 72 Confidence: 98.0% Identity: 18% Fold: Multidrug resistance efflux transporter EmrE Superfamily: Multidrug resistance efflux transporter EmrE Family: Multidrug resistance efflux transporter EmrE Phyre2 PDB 2i68 chain B Region: 225 - 288 Aligned: 58 Modelled: 64 Confidence: 79.9% Identity: 22% PDB header:transport protein Chain: B: PDB Molecule:protein emre; PDBTitle: cryo-em based theoretical model structure of transmembrane2 domain of the multidrug-resistance antiporter from e. coli3 emre Phyre2 PDB 3rko chain F Region: 2 - 146 Aligned: 145 Modelled: 145 Confidence: 7.6% Identity: 8% PDB header:oxidoreductase Chain: F: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: crystal structure of the membrane domain of respiratory complex i from2 e. coli at 3.0 angstrom resolution Phyre2 1 d1s7ba_ 2 c2i68B_ 3 c3rkoF_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1s7ba_ 98.0 18 Fold:Multidrug resistance efflux transporter EmrE Superfamily:Multidrug resistance efflux transporter EmrE Family:Multidrug resistance efflux transporter EmrE 2 c2i68B_ 79.9 22 PDB header:transport protein Chain: B: PDB Molecule:protein emre; PDBTitle: cryo-em based theoretical model structure of transmembrane2 domain of the multidrug-resistance antiporter from e. coli3 emre 3 c3rkoF_ 7.6 8 PDB header:oxidoreductase Chain: F: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: crystal structure of the membrane domain of respiratory complex i from2 e. coli at 3.0 angstrom resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0