Secondary structure and disorder prediction

1

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10

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20

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30

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40

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Sequence

M

K

S

N

R

Q

A

R

H

I

L

G

L

D

H

K

I

S

N

Q

R

K

I

V

T

E

G

D

K

S

S

V

V

N

N

P

T

G

R

K

R

P

A

E

K

Secondary structure

SS confidence

Disorder

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Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3hm0 chain C Region: 11 - 42 Aligned: 32 Modelled: 32 Confidence: 13.0% Identity: 13% PDB header:hydrolase Chain: C: PDB Molecule:probable thioesterase; PDBTitle: crystal structure of probable thioesterase from bartonella2 henselae Phyre2 PDB 2xs4 chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 12.1% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium Phyre2 PDB 1eak chain A domain 2 Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 9.5% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1xuc chain A domain 1 Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 9.0% Identity: 44% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1hov chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 8.8% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1hfc chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 8.7% Identity: 38% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1cxv chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 8.5% Identity: 44% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1mmq chain A Region: 9 - 32 Aligned: 14 Modelled: 24 Confidence: 8.5% Identity: 43% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1fbl chain A domain 2 Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 8.4% Identity: 38% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1q3a chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 8.1% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1hy7 chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 7.9% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1hv5 chain A Region: 9 - 34 Aligned: 16 Modelled: 26 Confidence: 7.2% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 1rm8 chain A Region: 9 - 15 Aligned: 7 Modelled: 7 Confidence: 6.2% Identity: 71% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 3bbn chain M Region: 1 - 13 Aligned: 13 Modelled: 13 Confidence: 5.5% Identity: 46% PDB header:ribosome Chain: M: PDB Molecule:ribosomal protein s13; PDBTitle: homology model for the spinach chloroplast 30s subunit2 fitted to 9.4a cryo-em map of the 70s chlororibosome. Phyre2 PDB 1y93 chain A domain 1 Region: 9 - 15 Aligned: 7 Modelled: 7 Confidence: 5.3% Identity: 71% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 2ovx chain A domain 1 Region: 9 - 15 Aligned: 7 Modelled: 7 Confidence: 5.2% Identity: 86% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 2hu9 chain B Region: 33 - 39 Aligned: 7 Modelled: 7 Confidence: 5.0% Identity: 71% PDB header:metal transport Chain: B: PDB Molecule:mercuric transport protein periplasmic component; PDBTitle: x-ray structure of the archaeoglobus fulgidus copz n-2 terminal domain Phyre2 1 c3hm0C_ 2 c2xs4A_ 3 d1eaka2 4 d1xuca1 5 d1hova_ 6 d1hfca_ 7 d1cxva_ 8 d1mmqa_ 9 d1fbla2 10 d1q3aa_ 11 d1hy7a_ 12 d1hv5a_ 13 d1rm8a_ 14 c3bbnM_ 15 d1y93a1 16 d2ovxa1 17 c2hu9B_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3hm0C_ 13.0 13 PDB header:hydrolase Chain: C: PDB Molecule:probable thioesterase; PDBTitle: crystal structure of probable thioesterase from bartonella2 henselae 2 c2xs4A_ 12.1 31 PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium 3 d1eaka2 9.5 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 4 d1xuca1 9.0 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 5 d1hova_ 8.8 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 6 d1hfca_ 8.7 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 7 d1cxva_ 8.5 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 8 d1mmqa_ 8.5 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 9 d1fbla2 8.4 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 10 d1q3aa_ 8.1 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 11 d1hy7a_ 7.9 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 12 d1hv5a_ 7.2 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 13 d1rm8a_ 6.2 71 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 14 c3bbnM_ 5.5 46 PDB header:ribosome Chain: M: PDB Molecule:ribosomal protein s13; PDBTitle: homology model for the spinach chloroplast 30s subunit2 fitted to 9.4a cryo-em map of the 70s chlororibosome. 15 d1y93a1 5.3 71 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 16 d2ovxa1 5.2 86 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 17 c2hu9B_ 5.0 71 PDB header:metal transport Chain: B: PDB Molecule:mercuric transport protein periplasmic component; PDBTitle: x-ray structure of the archaeoglobus fulgidus copz n-2 terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0