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Job DescriptionP77257
Confidence100.00%DateThu Jan 5 12:26:54 GMT 2012
Rank2Aligned Residues480
% Identity24%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   12.......20. ........30.........40.........50.........60.........70.........80........
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Query Sequence  LCARSVYKQY. . . SGVNVLKGIDFTLHQGEVHALLGGNGAGKSTLMKIIAGITPADSGTLEIEGNNYVRLTPVHAHQLGI
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREI. I
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460..... .
 
   8990.........100.........110.........120.........130.........140 .........150.......
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Query Sequence  YLVPQEPLLFPSLSIKENILFGLAKKQLSMQKMKNLLAALGCQFDLHSLAGS. . . . . . . . . . . LDVADRQMVEILRGLMR
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Template Conservation      
   
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Template Sequence  GVVSQEPVLFAT. TIAENIRYG. . REDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVR
Template Known Secondary structure  SS



SS.
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SS

TT
TTSTTGGG


SSSS
SS
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   467..470........ .480....... ..490.........500.........510.........520.........530.........540...
 
   158.160.........170.........180.........190.........200.........210.........220.........230.......
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Query Sequence  DSRILILDEPTASLTPAETERLFSRLQELLATGVGIVFISHKLPEIRQIADRISVMRDGTIALSGKTSELSTDDIIQAIT
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Template Conservation     
  


    

      
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Template Sequence  NPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELMREKGIYFKL
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




TS
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   544.....550.........560.........570.... .....580......... 590.........600.........610.........620.
 
   238.240.........250..
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Query Sequence  PAVREKSLSASQKLW. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                       
                                          
Template Sequence  VMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLIL
Template Known Secondary structure  T









TTT



SS
STT
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   622.......630.........640.........650.........660.........670.........680.........690.........700.
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation       
                   
   
   
               
 
  
   
           
   
     
Template Sequence  GIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIAN
Template Known Secondary structure 

S
S

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   759760.........770.........780.........790.........800.........810.........820.........830........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation       
        
 

 
    
                               
 
 
   

              
Template Sequence  LGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQ
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   839840.........850.........860.........870.........880.........890.........900.........910........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                       
  
                           
           
Template Sequence  SLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAT
Template Known Secondary structure 

TTTT
S
STTTSSSS
S
Template Predicted Secondary structure 





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   919920.........930.........940.........950.........960.........970.........980.........990........
 
   253......260.........270........ .280.........290.........300........
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Query Sequence  . . . . . . . . . . . . . . . . LELPGNRPQHAAGTPVLTLENLTGEG. . . . . . . . FRNVSLTLNAGEILGLAGLVGAGRTELAET
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Template Sequence  VSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQL
Template Known Secondary structure  S




SS
S




TTT





S
GGG

SS


SSS
SSSTT
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   9991000.........1010.........1020.........1030.........1040.........1050.........1060.........1070........
 
   309310.........320.........330.........340.........350.........360........ .370.........380......
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Query Sequence  LYGLRTLRGGRIMLNGKEINKLSTGERLLRGLVYLPEDRQSSGLNLDASLAWNVCALTHN. . LRGFWAKTAKDNATLERY
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Template Sequence  LERFYDPMAGSVFLDGKEIKQLN. VQWLRAQLGIVSQEP. . . . ILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQF
Template Known Secondary structure  TTSS

SSSSS
BTSS
.TTS
SS
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SSBT


SS



T
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   10791080.........1090.........1100. ........1110...... ...1120.........1130.........1140.........1150...
 
   387..390....... ..400.........410.........420.........430.........440.........450.........460.....
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Query Sequence  RRALNIKFNQP. EQAARTLSGGNQQKILIAKCLEASPQVLIVDEPTRGVDVSARNDIYQLLRSIAAQNVAVLLISSDLEE
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Template Sequence  IDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR. EGRTCIVIAHRLST
Template Known Secondary structure  SSTTTGGG
B
STTS
SS


SSS
SSS

S.SSS

S
TTG
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   1154.....1160.........1170.........1180.........1190.........1200.........1210........ .1220.........1230..
 
   466...470.........480.........490.........500....
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Query Sequence  IELMADRVYVMHQGEITHSALTERDINVETIMRVAFGDS
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Template Conservation     . 
 
 

  
 
 
 
    
    
    
   
Template Sequence  IQN. ADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQ
Template Known Secondary structure  GGS.
STB
S
S
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   1233.. ....1240.........1250.........1260.........1270
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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