Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP18390
DateThu Jan 5 11:36:53 GMT 2012
Unique Job ID1e6d0a3ede5e4aee

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1xhmb1
Top template information
Fold:Non-globular all-alpha subunits of globular proteins
Superfamily:Transducin (heterotrimeric G protein), gamma chain
Family:Transducin (heterotrimeric G protein), gamma chain
Confidence and coverage
Confidence: 30.5% Coverage: 7%
11 residues ( 7% of your sequence) have been modelled with 30.5% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
Warning: 59% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MMKTVKHLLCCAIAASALISTGVHAASWKDALSSAASELGNQNSTTQEGGWSLASLTNLL
Secondary structure 














SS confidence 



























































Disorder  ???













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   .........70.........80.........90.........100.........110.........120
Sequence  SSGNQALSADNMNNAAGILQYCAKQKLASVTDAENIKNQVLEKLGLNSEEQKEDTNYLDG
Secondary structure 

























SS confidence 



























































Disorder  ??????????????













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   .........130.........140.........150.........160....
Sequence  IQGLLKTKDGQQLNLDNIGTTPLAEKVKTKACDLVLKQGLNFIS
Secondary structure 











SS confidence 











































Disorder  ?
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1xhm chain B domain 1

3D model

Region: 75 - 85
Aligned: 11
Modelled: 11
Confidence: 30.5%
Identity: 36%
Fold: Non-globular all-alpha subunits of globular proteins
Superfamily: Transducin (heterotrimeric G protein), gamma chain
Family: Transducin (heterotrimeric G protein), gamma chain

Phyre2

PDB 1xhm chain B

3D model

Region: 75 - 85
Aligned: 11
Modelled: 11
Confidence: 30.4%
Identity: 36%
PDB header:signaling protein
Chain: B: PDB Molecule:guanine nucleotide-binding protein g(i)/g(s)
PDBTitle: the crystal structure of a biologically active peptide2 (sigk) bound to a g protein beta:gamma heterodimer

Phyre2

PDB 2kel chain B

3D model

Region: 81 - 103
Aligned: 23
Modelled: 23
Confidence: 26.5%
Identity: 35%
PDB header:transcription repressor
Chain: B: PDB Molecule:uncharacterized protein 56b;
PDBTitle: structure of the transcription regulator svtr from the2 hyperthermophilic archaeal virus sirv1

Phyre2

PDB 1elk chain A

3D model

Region: 78 - 85
Aligned: 8
Modelled: 8
Confidence: 11.0%
Identity: 38%
Fold: alpha-alpha superhelix
Superfamily: ENTH/VHS domain
Family: VHS domain

Phyre2

PDB 1xb4 chain A domain 1

3D model

Region: 78 - 87
Aligned: 10
Modelled: 10
Confidence: 10.6%
Identity: 50%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Vacuolar sorting protein domain

Phyre2

PDB 1g8m chain A domain 2

3D model

Region: 85 - 107
Aligned: 23
Modelled: 23
Confidence: 8.9%
Identity: 17%
Fold: Cytidine deaminase-like
Superfamily: Cytidine deaminase-like
Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC

Phyre2

PDB 2ahm chain A domain 1

3D model

Region: 80 - 104
Aligned: 25
Modelled: 25
Confidence: 8.4%
Identity: 12%
Fold: immunoglobulin/albumin-binding domain-like
Superfamily: Coronavirus NSP7-like
Family: Coronavirus NSP7-like

Phyre2

PDB 2zme chain D

3D model

Region: 78 - 86
Aligned: 9
Modelled: 9
Confidence: 7.7%
Identity: 33%
PDB header:protein transport
Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25;
PDBTitle: integrated structural and functional model of the human escrt-ii2 complex

Phyre2

PDB 1ysy chain A domain 1

3D model

Region: 80 - 104
Aligned: 25
Modelled: 25
Confidence: 7.4%
Identity: 12%
Fold: immunoglobulin/albumin-binding domain-like
Superfamily: Coronavirus NSP7-like
Family: Coronavirus NSP7-like

Phyre2

PDB 1ldm chain A domain 2

3D model

Region: 92 - 159
Aligned: 60
Modelled: 68
Confidence: 7.3%
Identity: 22%
Fold: LDH C-terminal domain-like
Superfamily: LDH C-terminal domain-like
Family: Lactate & malate dehydrogenases, C-terminal domain

Phyre2

PDB 3rru chain A

3D model

Region: 78 - 85
Aligned: 8
Modelled: 8
Confidence: 6.7%
Identity: 13%
PDB header:signaling protein
Chain: A: PDB Molecule:tom1l1 protein;
PDBTitle: x-ray crystal structure of the vhs domain of human tom1-like protein,2 northeast structural genomics consortium target hr3050e

Phyre2

PDB 1pkx chain A domain 2

3D model

Region: 85 - 107
Aligned: 23
Modelled: 23
Confidence: 6.6%
Identity: 22%
Fold: Cytidine deaminase-like
Superfamily: Cytidine deaminase-like
Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC

Phyre2

PDB 3cuq chain D

3D model

Region: 78 - 86
Aligned: 9
Modelled: 9
Confidence: 6.4%
Identity: 33%
PDB header:protein transport
Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25;
PDBTitle: integrated structural and functional model of the human escrt-ii2 complex

Phyre2

PDB 1mwp chain A

3D model

Region: 77 - 84
Aligned: 8
Modelled: 8
Confidence: 6.4%
Identity: 75%
Fold: SRCR-like
Superfamily: A heparin-binding domain
Family: A heparin-binding domain

Phyre2

PDB 3c2q chain A

3D model

Region: 77 - 87
Aligned: 11
Modelled: 11
Confidence: 5.9%
Identity: 36%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized conserved protein;
PDBTitle: crystal structure of conserved putative lor/sdh protein2 from methanococcus maripaludis s2

Phyre2

PDB 1omw chain G

3D model

Region: 75 - 85
Aligned: 11
Modelled: 11
Confidence: 5.9%
Identity: 36%
Fold: Non-globular all-alpha subunits of globular proteins
Superfamily: Transducin (heterotrimeric G protein), gamma chain
Family: Transducin (heterotrimeric G protein), gamma chain

Phyre2

PDB 1mhq chain A

3D model

Region: 78 - 85
Aligned: 8
Modelled: 8
Confidence: 5.7%
Identity: 25%
Fold: alpha-alpha superhelix
Superfamily: ENTH/VHS domain
Family: VHS domain

Phyre2

PDB 1ceu chain A

3D model

Region: 75 - 85
Aligned: 11
Modelled: 11
Confidence: 5.5%
Identity: 9%
PDB header:viral protein
Chain: A: PDB Molecule:protein (hiv-1 regulatory protein n-terminal
PDBTitle: nmr structure of the (1-51) n-terminal domain of the hiv-12 regulatory protein

Phyre2
1

d1xhmb1
2

c1xhmB_
3

c2kelB_
4

d1elka_
5

d1xb4a1
6

d1g8ma2
7

d2ahma1
8

c2zmeD_
9

d1ysya1
10

d1ldma2
11

c3rruA_
12

d1pkxa2
13

c3cuqD_
14

d1mwpa_
15

c3c2qA_
16

d1omwg_
17

d1mhqa_
18

c1ceuA_



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1xhmb1



30.5 36 Fold:Non-globular all-alpha subunits of globular proteins
Superfamily:Transducin (heterotrimeric G protein), gamma chain
Family:Transducin (heterotrimeric G protein), gamma chain
2c1xhmB_



30.4 36 PDB header:signaling protein
Chain: B: PDB Molecule:guanine nucleotide-binding protein g(i)/g(s)
PDBTitle: the crystal structure of a biologically active peptide2 (sigk) bound to a g protein beta:gamma heterodimer
3c2kelB_



26.5 35 PDB header:transcription repressor
Chain: B: PDB Molecule:uncharacterized protein 56b;
PDBTitle: structure of the transcription regulator svtr from the2 hyperthermophilic archaeal virus sirv1
4d1elka_



11.0 38 Fold:alpha-alpha superhelix
Superfamily:ENTH/VHS domain
Family:VHS domain
5d1xb4a1



10.6 50 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:Vacuolar sorting protein domain
6d1g8ma2



8.9 17 Fold:Cytidine deaminase-like
Superfamily:Cytidine deaminase-like
Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
7d2ahma1



8.4 12 Fold:immunoglobulin/albumin-binding domain-like
Superfamily:Coronavirus NSP7-like
Family:Coronavirus NSP7-like
8c2zmeD_



7.7 33 PDB header:protein transport
Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25;
PDBTitle: integrated structural and functional model of the human escrt-ii2 complex
9d1ysya1



7.4 12 Fold:immunoglobulin/albumin-binding domain-like
Superfamily:Coronavirus NSP7-like
Family:Coronavirus NSP7-like
10d1ldma2



7.3 22 Fold:LDH C-terminal domain-like
Superfamily:LDH C-terminal domain-like
Family:Lactate & malate dehydrogenases, C-terminal domain
11c3rruA_



6.7 13 PDB header:signaling protein
Chain: A: PDB Molecule:tom1l1 protein;
PDBTitle: x-ray crystal structure of the vhs domain of human tom1-like protein,2 northeast structural genomics consortium target hr3050e
12d1pkxa2



6.6 22 Fold:Cytidine deaminase-like
Superfamily:Cytidine deaminase-like
Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
13c3cuqD_



6.4 33 PDB header:protein transport
Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25;
PDBTitle: integrated structural and functional model of the human escrt-ii2 complex
14d1mwpa_



6.4 75 Fold:SRCR-like
Superfamily:A heparin-binding domain
Family:A heparin-binding domain
15c3c2qA_



5.9 36 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized conserved protein;
PDBTitle: crystal structure of conserved putative lor/sdh protein2 from methanococcus maripaludis s2
16d1omwg_



5.9 36 Fold:Non-globular all-alpha subunits of globular proteins
Superfamily:Transducin (heterotrimeric G protein), gamma chain
Family:Transducin (heterotrimeric G protein), gamma chain
17d1mhqa_



5.7 25 Fold:alpha-alpha superhelix
Superfamily:ENTH/VHS domain
Family:VHS domain
18c1ceuA_



5.5 9 PDB header:viral protein
Chain: A: PDB Molecule:protein (hiv-1 regulatory protein n-terminal
PDBTitle: nmr structure of the (1-51) n-terminal domain of the hiv-12 regulatory protein

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0