Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	D	S	L	A	K	A	G	K	Y	L	G	Q	A	A	K	L	M	I	G	M	P	D	Y	D	N	Y	V	E	H	M	R	V	N	H	P	D	Q	T	P	M	T	Y	E	E	F	F	R	E	R	Q	D	A	R	Y	G	G	K	G
Secondary structure
SS confidence
Disorder		?																																																						?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.
Sequence		G	A	R	C	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1i1r chain B Region: 17 - 41 Aligned: 25 Modelled: 25 Confidence: 40.1% Identity: 12% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 1alu chain A Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 27.0% Identity: 17% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 2ghf chain A Region: 23 - 43 Aligned: 21 Modelled: 21 Confidence: 20.5% Identity: 29% PDB header:transcription, metal binding protein Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 1; PDBTitle: solution structure of the complete zinc-finger region of2 human zinc-fingers and homeoboxes 1 (zhx1) Phyre2 PDB 4a19 chain Q Region: 2 - 27 Aligned: 26 Modelled: 26 Confidence: 18.4% Identity: 19% PDB header:ribosome Chain: Q: PDB Molecule:60s ribosomal protein l36; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 26s rrna and3 proteins of molecule 2. Phyre2 PDB 2ffs chain A domain 1 Region: 37 - 49 Aligned: 13 Modelled: 13 Confidence: 18.0% Identity: 0% Fold: TBP-like Superfamily: Bet v1-like Family: PA1206-like Phyre2 PDB 1bh0 chain A Region: 23 - 35 Aligned: 13 Modelled: 13 Confidence: 17.8% Identity: 23% PDB header:synthetic hormone Chain: A: PDB Molecule:glucagon; PDBTitle: structure of a glucagon analog Phyre2 PDB 2l3y chain A Region: 17 - 38 Aligned: 22 Modelled: 22 Confidence: 15.2% Identity: 36% PDB header:transcription Chain: A: PDB Molecule:interleukin-6; PDBTitle: solution structure of mouse il-6 Phyre2 PDB 1tjl chain D Region: 13 - 55 Aligned: 35 Modelled: 43 Confidence: 13.2% Identity: 23% PDB header:transcription Chain: D: PDB Molecule:dnak suppressor protein; PDBTitle: crystal structure of transcription factor dksa from e. coli Phyre2 PDB 2ct1 chain A Region: 23 - 43 Aligned: 21 Modelled: 21 Confidence: 11.6% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:transcriptional repressor ctcf; PDBTitle: solution structure of the zinc finger domain of2 transcriptional repressor ctcf protein Phyre2 PDB 3izc chain K Region: 2 - 27 Aligned: 26 Modelled: 26 Confidence: 11.4% Identity: 12% PDB header:ribosome Chain: K: PDB Molecule:60s ribosomal protein rpl16 (l13p); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome Phyre2 PDB 1rhg chain A Region: 17 - 39 Aligned: 23 Modelled: 23 Confidence: 11.1% Identity: 17% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 1odm chain A Region: 35 - 62 Aligned: 28 Modelled: 28 Confidence: 10.3% Identity: 14% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 3hs2 chain H Region: 33 - 59 Aligned: 26 Modelled: 27 Confidence: 10.1% Identity: 12% PDB header:antitoxin Chain: H: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd truncated to residue 57 in an orthorhombic2 space group Phyre2 PDB 1puo chain A Region: 26 - 55 Aligned: 30 Modelled: 30 Confidence: 9.8% Identity: 20% PDB header:allergen Chain: A: PDB Molecule:major allergen i polypeptide, fused chain 2, PDBTitle: crystal structure of fel d 1- the major cat allergen Phyre2 PDB 3izb chain U Region: 35 - 60 Aligned: 25 Modelled: 26 Confidence: 8.8% Identity: 24% PDB header:ribosome Chain: U: PDB Molecule:40s ribosomal protein s24; PDBTitle: localization of the small subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome Phyre2 PDB 2g1d chain A domain 1 Region: 35 - 60 Aligned: 25 Modelled: 26 Confidence: 8.7% Identity: 16% Fold: Ribosomal proteins S24e, L23 and L15e Superfamily: Ribosomal proteins S24e, L23 and L15e Family: Ribosomal protein S24e Phyre2 PDB 2knc chain B Region: 44 - 59 Aligned: 16 Modelled: 16 Confidence: 8.5% Identity: 25% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1bge chain A Region: 17 - 38 Aligned: 22 Modelled: 22 Confidence: 8.0% Identity: 18% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 1kuz chain B Region: 47 - 57 Aligned: 11 Modelled: 11 Confidence: 7.7% Identity: 36% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: solution structure of the membrane proximal regions of2 alpha-iib and beta-3 integrins Phyre2 PDB 1bgc chain A Region: 17 - 39 Aligned: 23 Modelled: 23 Confidence: 7.5% Identity: 17% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 1 d1i1rb_ 2 d1alua_ 3 c2ghfA_ 4 c4a19Q_ 5 d2ffsa1 6 c1bh0A_ 7 c2l3yA_ 8 c1tjlD_ 9 c2ct1A_ 10 c3izck_ 11 d1rhga_ 12 d1odma_ 13 c3hs2H_ 14 c1puoA_ 15 c3izbU_ 16 d2g1da1 17 c2kncB_ 18 d1bgea_ 19 c1kuzB_ 20 d1bgca_ 21 22 23 24 25 26 27 28 29 30 31 32 33

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1i1rb_ 40.1 12 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Long-chain cytokines 2 d1alua_ 27.0 17 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Long-chain cytokines 3 c2ghfA_ 20.5 29 PDB header:transcription, metal binding protein Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 1; PDBTitle: solution structure of the complete zinc-finger region of2 human zinc-fingers and homeoboxes 1 (zhx1) 4 c4a19Q_ 18.4 19 PDB header:ribosome Chain: Q: PDB Molecule:60s ribosomal protein l36; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 26s rrna and3 proteins of molecule 2. 5 d2ffsa1 18.0 0 Fold:TBP-like Superfamily:Bet v1-like Family:PA1206-like 6 c1bh0A_ 17.8 23 PDB header:synthetic hormone Chain: A: PDB Molecule:glucagon; PDBTitle: structure of a glucagon analog 7 c2l3yA_ 15.2 36 PDB header:transcription Chain: A: PDB Molecule:interleukin-6; PDBTitle: solution structure of mouse il-6 8 c1tjlD_ 13.2 23 PDB header:transcription Chain: D: PDB Molecule:dnak suppressor protein; PDBTitle: crystal structure of transcription factor dksa from e. coli 9 c2ct1A_ 11.6 19 PDB header:transcription Chain: A: PDB Molecule:transcriptional repressor ctcf; PDBTitle: solution structure of the zinc finger domain of2 transcriptional repressor ctcf protein 10 c3izck_ 11.4 12 PDB header:ribosome Chain: K: PDB Molecule:60s ribosomal protein rpl16 (l13p); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 11 d1rhga_ 11.1 17 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Long-chain cytokines 12 d1odma_ 10.3 14 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 13 c3hs2H_ 10.1 12 PDB header:antitoxin Chain: H: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd truncated to residue 57 in an orthorhombic2 space group 14 c1puoA_ 9.8 20 PDB header:allergen Chain: A: PDB Molecule:major allergen i polypeptide, fused chain 2, PDBTitle: crystal structure of fel d 1- the major cat allergen 15 c3izbU_ 8.8 24 PDB header:ribosome Chain: U: PDB Molecule:40s ribosomal protein s24; PDBTitle: localization of the small subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 16 d2g1da1 8.7 16 Fold:Ribosomal proteins S24e, L23 and L15e Superfamily:Ribosomal proteins S24e, L23 and L15e Family:Ribosomal protein S24e 17 c2kncB_ 8.5 25 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 18 d1bgea_ 8.0 18 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Long-chain cytokines 19 c1kuzB_ 7.7 36 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: solution structure of the membrane proximal regions of2 alpha-iib and beta-3 integrins 20 d1bgca_ 7.5 17 Fold:4-helical cytokines Superfamily:4-helical cytokines Family:Long-chain cytokines 21 c2hu9B_ not modelled 7.3 43 PDB header:metal transport Chain: B: PDB Molecule:mercuric transport protein periplasmic component; PDBTitle: x-ray structure of the archaeoglobus fulgidus copz n-2 terminal domain 22 c1nauA_ not modelled 6.8 25 PDB header:hormone/growth factor Chain: A: PDB Molecule:glucagon; PDBTitle: nmr solution structure of the glucagon antagonist [deshis1,2 desphe6, glu9]glucagon amide in the presence of3 perdeuterated dodecylphosphocholine micelles 23 d2diia1 not modelled 6.8 36 Fold:BSD domain-like Superfamily:BSD domain-like Family:BSD domain 24 c3g9wC_ not modelled 6.5 15 PDB header:cell adhesion Chain: C: PDB Molecule:integrin beta-1d; PDBTitle: crystal structure of talin2 f2-f3 in complex with the integrin beta1d2 cytoplasmic tail 25 d2ejna1 not modelled 6.5 20 Fold:Uteroglobin-like Superfamily:Uteroglobin-like Family:Uteroglobin-like 26 d1mtyd_ not modelled 6.2 11 Fold:Ferritin-like Superfamily:Ferritin-like Family:Ribonucleotide reductase-like 27 c3iz5k_ not modelled 6.1 13 PDB header:ribosome Chain: K: PDB Molecule:60s ribosomal protein l13a (l13p); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome 28 c1d0rA_ not modelled 5.9 23 PDB header:hormone/growth factor Chain: A: PDB Molecule:glucagon-like peptide-1-(7-36)-amide; PDBTitle: solution structure of glucagon-like peptide-1-(7-36)-amide2 in trifluoroethanol/water 29 c2diiA_ not modelled 5.7 36 PDB header:transcription Chain: A: PDB Molecule:tfiih basal transcription factor complex p62 PDBTitle: solution structure of the bsd domain of human tfiih basal2 transcription factor complex p62 subunit 30 d2v94a1 not modelled 5.6 12 Fold:Ribosomal proteins S24e, L23 and L15e Superfamily:Ribosomal proteins S24e, L23 and L15e Family:Ribosomal protein S24e 31 c3e53A_ not modelled 5.4 14 PDB header:ligase Chain: A: PDB Molecule:fatty-acid-coa ligase fadd28; PDBTitle: crystal structure of n-terminal domain of a fatty acyl amp2 ligase faal28 from mycobacterium tuberculosis 32 d1fmta1 not modelled 5.3 8 Fold:FMT C-terminal domain-like Superfamily:FMT C-terminal domain-like Family:Post formyltransferase domain 33 c2l9vA_ not modelled 5.3 50 PDB header:rna binding protein Chain: A: PDB Molecule:pre-mrna-processing factor 40 homolog a; PDBTitle: nmr structure of the ff domain l24a mutant's folding transition state

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0